CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD193
Family Name Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Family
No. of Seeds 4 No. of Other Members 36
Family Centroid CFAMM00141972 Functional Category Clinical Trial Drug with Natural Product
Superfamily Reverse transcriptase and Receptor-type tyrosine-protein kinase FLT3 Binder Superfamily
Class Class 952

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
D(4) dopamine receptor Ligand SPI-376 Family 7 84
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Cyclin-dependent kinase 5 Inhibitor 9-nitropaullone Family 2 13
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 16 0
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 5 Inhibi... 2 5
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Platelet-derived growth factor receptor alpha and Platelet-der... 3 3
Serine/threonine-protein kinase Chk1 Inhibitor BIS-IMIDE A Family 1 3
Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... 10 26
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Adenosine receptor A3 and Potassium voltage-gated channel subf... 1 18
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Endothelin B receptor Ligand IRL-2500 Family 34 87
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Histone deacetylase Inhibitor ST-5732 Family 8 6
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Coagulation factor X and Prothrombin inhibitor SureCN763988 fa... 31 86
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Cathepsin K inhibitor (1R,2R)-2-(6-chloro-1,3,4,5-tetrahydropy... 2 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Serine/threonine-protein kinase Chk1 inhibitor SureCN5551829 f... 1 14
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Leucine-rich repeat serine/threonine-protein kinase 2 and Plat... 1 0
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Platelet-derived growth factor receptor beta and Vascular endo... 1 0
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 7 18
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN4998361 family 1 1
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Glycogen phosphorylase, liver form inhibitor 2-[(1R,2R)-2-[(5-... 3 2
Kinesin-like protein KIF11 inhibitor 9-(trifluoromethyl)-1,2,4... 4 1
Vascular endothelial growth factor receptor 2 ligand 3-[2-[(Z)... 1 3
Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... 1 0
(2S)-1-[(2S)-2-[(5-chloro-1-methylindole-2-carbonyl)amino]-4-m... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00141972 DCL000292 Clinical Trial Drug SU5614
CFAMM00141993 DNC004132 Investigative Drug SU-11652
CFAMM00142000 DNC011203 Investigative Drug 3-Chloro-N-(2-methyl-1H-indol-5-yl)benzamide
CFAMM00141962 DNC010739 Investigative Drug (2'Z,3'E)-5-Chloro-5'-chloro-indirubin-3'-oxime

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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