CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD195
Family Name Multidrug resistance protein Inhibitor Tariquidar Family
No. of Seeds 3 No. of Other Members 60
Family Centroid CFAMM00142045 Functional Category Clinical Trial Drug with Natural Product
Superfamily Multidrug resistance protein Inhibitor Tariquidar Superfamily
Class Class 82

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK2... 15 18
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 22
cAMP-specific 3',5'-cyclic phosphodiesterase 4C and cAMP-speci... 12 2
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
B2 bradykinin receptor ligand SureCN6640854 family 7 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Cannabinoid receptor 2 ligand 8-ethoxy-7-methoxy-2-oxo-N-(2-py... 2 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cholinesterase and Acetylcholinesterase inhibitor tacrine deri... 10 0
Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy... 12 6
Hepatocyte growth factor receptor ligand 1-(2-chlorophenyl)-N-... 14 8
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854955 f... 2 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Platelet-activating factor receptor ligand 5,6-dimethoxy-N,N-d... 2 3
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
72 kDa type IV collagenase and Aminopeptidase N inhibitor ly52... 1 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 12
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
Transient receptor potential cation channel subfamily V member... 3 2
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
Menin and Histone-lysine N-methyltransferase 2A inhibitor CHEM... 1 0
Platelet-activating factor receptor ligand AGN-PC-001U4L family 2 0
NP (s,z)-n'-(1-((6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin... 1 1
2-methyl-5-oxo-1,6-naphthyridine-3-carboxylate NP Methyl 6-(3,... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00142045 DCL000295 Clinical Trial Drug Tariquidar
CFAMM00142024 DNC001301 Investigative Drug SC-79407
CFAMM00142082 DNC013543 Investigative Drug XR-9544

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21760 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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