CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD196
Family Name Endothelin-1 receptor Ligand Atrasentan Family
No. of Seeds 127 No. of Other Members 336
Family Centroid CFAMM00142238 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily Endothelin-1 receptor Ligand Atrasentan Superfamily
Class Class 954

Cousin Family NamesSeedsMembers
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Zucapsacin family 7 177
Dopamine receptor Ligand Docarpamine Family 1 8
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Myeloperoxidase Inhibitor AZD5904 Family 1 2
Substance-P receptor Ligand DA-5018 Family 14 73
D(3) dopamine receptor Ligand U-99194A Family 7 33
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Vasopeptidase Inhibitor Fasidotril Family 3 7
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Histamine H3 receptor Ligand A-349821 Family 49 228
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36
DNA topoisomerase 1 Inhibitor NSC-341622 Family 1 1
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Integrin beta-1 and Integrin alpha-4 inhibitor (3S)-3-(3,4-dim... 5 61
Pol polyprotein inhibitor 180968-31-4 family 8 13
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 5 4
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 3 2
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 4 10
Endothelin B receptor and Endothelin-1 receptor ligand SureCN8... 6 4
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-075O... 14 27
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Matrix metalloproteinase-15 and Matrix metalloproteinase-16 in... 1 0
Type-2 angiotensin II receptor ligand SureCN244657 family 7 11
Neuropeptide S receptor and Survival motor neuron protein liga... 1 2
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 12 0
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)... 17 19
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Potassium voltage-gated channel subfamily H member 2 and Melan... 2 12
Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Integrin beta-1 and Integrin alpha-4 inhibitor AGN-PC-02YIN5 f... 3 5
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-benzylsul... 2 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Mu-type opioid receptor ligand AGN-PC-075GAW family 2 1
Plasmepsin-1 and Plasmepsin-2 inhibitor N-[(2S,3S)-5-[[(2S)-1-... 1 2
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Bone morphogenetic protein 1 inhibitor benzyl N-[(4R)-4-[1,3-b... 6 25
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Caspase-1 and Caspase-8 inhibitor N-[(6S)-1-[2-[[(3S)-2-hydrox... 3 1
Prothrombin inhibitor CHEMBL2448373 family 3 0
Melanocortin receptor 4 ligand [(3R,4S)-4-(4-chlorophenyl)-1-p... 5 8
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 12 3
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Caspase-1 inhibitor (3S)-3-[2-[3-(naphthalene-1-carbonylamino)... 13 5
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Bone morphogenetic protein 1 inhibitor (2R)-2-[1,3-benzodioxol... 2 1
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6429531 f... 2 0
Motilin receptor ligand N-[1-[(1-amino-1-oxo-4-phenylbutan-2-y... 4 3
Integrin beta-3 and Integrin alpha-V inhibitor (3R)-3-(1,3-ben... 5 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Substance-P receptor ligand SureCN9054944 family 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 13
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 10 1
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Kappa-type opioid receptor ligand N-[(1S)-2-[(3S)-3-hydroxypyr... 2 0
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
Mu-type opioid receptor ligand N-[2-[(2-amino-2-oxoethyl)-[2-(... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor 4-(3... 1 0
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor Sure... 4 4
Nuclear receptor ROR-gamma ligand 3-(1,3-benzodioxol-5-yl)-1-(... 3 36
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 0
Kappa-type opioid receptor ligand 1-[4-acetyl-2-[[(3S)-3-hydro... 1 0
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 1 3
Protease inhibitor (2S)-N-[4-(1,3-benzodioxol-5-ylmethylamino)... 1 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (E)-... 1 0
Tyrosine-protein phosphatase non-receptor type 2 and Tyrosine-... 6 0
72 kDa type IV collagenase and Aminopeptidase N inhibitor meth... 1 1
Chymase and Chymotrypsinogen A inhibitor N-[(2S)-4-chloro-3-ox... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor meth... 1 0
Prostaglandin D2 receptor ligand (E)-7-[(1S,3S,4R,5R)-4-(1,3-b... 1 0
NP 3-((3a's,6a'r)-5'-(benzo[d][1,3]dioxol-5-ylmethyl)-7-chloro... 32 0
spiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole... 32 0
Putative NP ZINC04041531 Family 40 0
Putative NP ZINC20611663 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00142291 CHEMBL326861 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-1-[2-[propyl(propylsulfonyl)amino]ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142365 CHEMBL9223 Bioactive (2S,3S,4R)-4-(1,3-benzodioxol-5-yl)-1-[2-[bis(2-methoxyethyl)amino]-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142475 CHEMBL9050 Bioactive (2S,3S,4R)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-1-[2-[methyl(pentyl)amino]-2-oxoethyl]pyrrolidine-3-carboxylic acid
CFAMM00142543 CHEMBL111218 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-[(E)-pent-3-enyl]pyrrolidine-3-carboxylic acid
CFAMM00142584 CHEMBL419749 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-1-[2-[pentylsulfonyl(propyl)amino]ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142257 CHEMBL325581 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[3-chloropropylsulfonyl(propyl)amino]ethyl]-2-(3-fluoro-4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142271 CHEMBL323175 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-[3-(1,3-dioxolan-2-yl)propyl]pyrrolidine-3-carboxylic acid
CFAMM00142331 CHEMBL9162 Bioactive SureCN4996110
CFAMM00142181 CHEMBL146684 Bioactive (3R)-3-(1,3-benzodioxol-5-yl)-3-[[(3R)-1-[3-(1-methylpiperidin-4-yl)propanoyl]piperidine-3-carbonyl]amino]propanoic acid
CFAMM00142502 CHEMBL111023 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(2-propylpentyl)pyrrolidine-3-carboxylic acid
CFAMM00142358 CHEMBL267695 Bioactive (2S,3S,4R)-4-(1,3-benzodioxol-5-yl)-1-[2-[butyl(methyl)amino]-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142148 CHEMBL320763 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methylpent-4-enyl)pyrrolidine-3-carboxylic acid
CFAMM00142438 CHEMBL267761 Bioactive (2S,3S,4R)-4-(1,3-benzodioxol-5-yl)-1-[2-(butylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142222 CHEMBL110064 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-pent-4-enylpyrrolidine-3-carboxylic acid
CFAMM00142481 CHEMBL128061 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-propylphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142310 CHEMBL321035 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-1-[2-[(4-methoxyphenyl)sulfonyl-propylamino]ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142351 CHEMBL9119 Bioactive (2S,3S,4R)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-1-[2-[methyl(2-methylpropyl)amino]-2-oxoethyl]pyrrolidine-3-carboxylic acid
CFAMM00142509 CHEMBL331936 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-1-[2-oxo-2-(1-phenylbutylamino)ethyl]pyrrolidine-3-carboxylic acid;2,2,2-trifluoroacetic acid
CFAMM00142200 CHEMBL108142 Bioactive (2R,3R,4S)-1-[2-[benzenesulfonyl(propyl)amino]ethyl]-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142604 CHEMBL112877 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-[2-(1,3-dioxan-2-yl)ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142316 CHEMBL111769 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[ethylsulfonyl(propyl)amino]ethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142256 CHEMBL110899 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-1-[2-[2-methylpropylsulfonyl(propyl)amino]ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142180 CHEMBL110366 Bioactive (2R,3R,4S)-1-[2-(dibutylamino)-2-oxoethyl]-4-(2,3-dihydro-1-benzofuran-5-yl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142519 CHEMBL322799 Bioactive SureCN14203773
CFAMM00142583 CHEMBL109474 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-[2-(oxan-4-yl)ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142221 CHEMBL9212 Bioactive (2S,3S,4R)-4-(1,3-benzodioxol-5-yl)-1-[2-(diethylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142147 CHEMBL111728 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-1-[2-[methyl(propylsulfonyl)amino]ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142207 CHEMBL111712 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-[4-(methoxymethoxy)phenyl]-1-[2-[pentylsulfonyl(propyl)amino]ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142535 CHEMBL111517 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[heptylsulfonyl(propyl)amino]ethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142562 CHEMBL403273 Bioactive 2-(1,3-benzodioxol-5-yl)-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide
CFAMM00142249 CHEMBL9139 Bioactive (2S,3S,4R)-4-(1,3-benzodioxol-5-yl)-1-[2-(dipropylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142336 CHEMBL123408 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[(2,2-dimethyl-1-phenylpropyl)amino]-2-oxoethyl]-2-[4-(2-methoxyethoxy)phenyl]pyrrolidine-3-carboxylic acid;2,2,2-trifluoroacetic acid
CFAMM00142350 CHEMBL109926 Bioactive (2S,3R,4S)-1-[2-(dibutylamino)-2-oxoethyl]-2-[(Z)-2,2-dimethylpent-3-enyl]-4-(7-methoxy-1,3-benzodioxol-5-yl)pyrrolidine-3-carboxylic acid
CFAMM00142199 CHEMBL9488 Bioactive SureCN6546741
CFAMM00142589 CHEMBL419211 Bioactive (2R,3R,4S)-1-[2-(dibutylamino)-2-oxoethyl]-4-(2,3-dihydro-1H-inden-5-yl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142289 CHEMBL112314 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(5,5,5-trifluoropentyl)pyrrolidine-3-carboxylic acid
CFAMM00142377 CHEMBL128479 Bioactive (2R,3R,4S)-1-[2-(dibutylamino)-2-oxoethyl]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(4-ethyl-3-fluorophenyl)pyrrolidine-3-carboxylic acid
CFAMM00142213 CHEMBL113529 Bioactive (2R,3R,4S)-1-[2-(dibutylamino)-2-oxoethyl]-2,4-bis(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142329 CHEMBL111010 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-[2-[pentylsulfonyl(propyl)amino]ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142403 CHEMBL326685 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-[(Z)-4-methylhex-3-enyl]pyrrolidine-3-carboxylic acid
CFAMM00142595 CHEMBL333972 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(2,6-diethyl-4-fluoroanilino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142119 CHEMBL334076 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-1-[2-oxo-2-(1-phenylpentylamino)ethyl]pyrrolidine-3-carboxylic acid;2,2,2-trifluoroacetic acid
CFAMM00142146 CHEMBL269141 Bioactive (2S,3S,4R)-4-(1,3-benzodioxol-5-yl)-1-[2-[bis(3-methylbutyl)amino]-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142206 CHEMBL9283 Bioactive (2S,3S,4R)-4-(1,3-benzodioxol-5-yl)-1-[2-(N-butylanilino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142435 CHEMBL109248 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-pentylpyrrolidine-3-carboxylic acid
CFAMM00142220 CHEMBL323989 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-[2-(1,3-dioxolan-2-yl)ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142547 CHEMBL111355 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[butyl(propylsulfonyl)amino]ethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142248 CHEMBL321673 Bioactive SureCN795886
CFAMM00142426 CHEMBL323485 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(3-cyclopropylidenepropyl)-1-[2-(dibutylamino)-2-oxoethyl]pyrrolidine-3-carboxylic acid
CFAMM00142588 CHEMBL109478 Bioactive SureCN14202334
CFAMM00142275 CHEMBL267279 Bioactive (2S,3S,4R)-4-(1,3-benzodioxol-5-yl)-1-[2-[hexyl(methyl)amino]-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142127 CHEMBL8736 Bioactive (2S,3S,4R)-4-(1,3-benzodioxol-5-yl)-1-[2-[cyclohexyl(methyl)amino]-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142138 CHEMBL330895 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[(2-ethyl-1-phenylbutyl)amino]-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid;2,2,2-trifluoroacetic acid
CFAMM00142507 CHEMBL9334 Bioactive (2S,3S,4R)-4-(1,3-benzodioxol-5-yl)-1-[2-[butyl(propyl)amino]-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142472 CHEMBL323055 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(3-fluoro-4-methoxyphenyl)-1-[2-[2-methylpropylsulfonyl(propyl)amino]ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142301 CHEMBL110053 Bioactive SureCN5003930
CFAMM00142314 CHEMBL112417 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(2-methylpentyl)pyrrolidine-3-carboxylic acid
CFAMM00142341 CHEMBL366441 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-1-[2-[(2-methyl-1-phenylpropyl)amino]-2-oxoethyl]pyrrolidine-3-carboxylic acid
CFAMM00142178 CHEMBL109644 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(3-fluoro-4-methoxyphenyl)-1-[2-[hexylsulfonyl(propyl)amino]ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142355 CHEMBL123107 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-1-[2-oxo-2-(1-phenylpropylamino)ethyl]pyrrolidine-3-carboxylic acid;2,2,2-trifluoroacetic acid
CFAMM00142191 CHEMBL421073 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(2-ethyl-6-methylanilino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142594 CHEMBL353560 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(5-methylhexyl)pyrrolidine-3-carboxylic acid
CFAMM00142294 CHEMBL323951 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-[(Z)-2,2-dimethylpent-3-enyl]pyrrolidine-3-carboxylic acid
CFAMM00142129 CHEMBL110695 Bioactive SureCN14202231
CFAMM00142118 CHEMBL339904 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(3-fluoro-4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142158 CHEMBL340575 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-ethylphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142505 CHEMBL332289 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[(2,2-dimethyl-1-phenylpropyl)amino]-2-oxoethyl]-2-[4-(2-propan-2-yloxyethoxy)phenyl]pyrrolidine-3-carboxylic acid;2,2,2-trifluoroacetic acid
CFAMM00142560 CHEMBL109408 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[benzylsulfonyl(propyl)amino]ethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142287 CHEMBL266354 Bioactive (2S,3S,4R)-4-(1,3-benzodioxol-5-yl)-1-[2-[bis(2-methylpropyl)amino]-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142211 CHEMBL8923 Bioactive AGN-PC-00ITZ9
CFAMM00142441 CHEMBL123654 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[bis(2-methylphenyl)methylamino]-2-oxoethyl]-2-[4-(2-methoxyethoxy)phenyl]pyrrolidine-3-carboxylic acid;2,2,2-trifluoroacetic acid
CFAMM00142300 CHEMBL129060 Bioactive (2R,3R,4S)-1-[2-(dibutylamino)-2-oxoethyl]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(4-ethylphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142388 CHEMBL336272 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methylphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142190 CHEMBL111612 Bioactive SureCN795037
CFAMM00142593 CHEMBL322297 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(3-fluoro-4-methoxyphenyl)-1-[2-[3-methylbutylsulfonyl(propyl)amino]ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142267 CHEMBL108748 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[2-methoxyethylsulfonyl(propyl)amino]ethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142464 CHEMBL326191 Bioactive (2R,3R,4S)-1-[2-(dibutylamino)-2-oxoethyl]-4-(2,3-dihydro-1-benzofuran-6-yl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142117 CHEMBL110700 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[benzylsulfonyl(propyl)amino]ethyl]-2-(3-fluoro-4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142183 CHEMBL324214 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[3-chloropropylsulfonyl(propyl)amino]ethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142573 CHEMBL419367 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(3-fluoro-4-methoxyphenyl)-1-[2-[propyl(4,4,4-trifluorobutylsulfonyl)amino]ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142586 CHEMBL324586 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(2,2,4-trimethylpent-3-enyl)pyrrolidine-3-carboxylic acid
CFAMM00142136 CHEMBL420729 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-1-[2-oxo-2-(2,4,6-triethylanilino)ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142374 CHEMBL339969 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-[4-(trifluoromethyl)phenyl]pyrrolidine-3-carboxylic acid
CFAMM00142210 CHEMBL340190 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(3,4-difluorophenyl)pyrrolidine-3-carboxylic acid
CFAMM00142440 CHEMBL332387 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(2-ethyl-6-methoxyanilino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142599 CHEMBL432974 Bioactive SureCN4998049
CFAMM00142150 CHEMBL273642 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[bis(2-methylphenyl)methylamino]-2-oxoethyl]-2-[4-(2-propan-2-yloxyethoxy)phenyl]pyrrolidine-3-carboxylic acid;2,2,2-trifluoroacetic acid
CFAMM00142483 CHEMBL326719 Bioactive (2R,3R,4S)-1-[2-(dibutylamino)-2-oxoethyl]-4-(3-fluorophenyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142241 CHEMBL9502 Bioactive (2S,3S,4R)-4-(1,3-benzodioxol-5-yl)-1-[2-[butyl(ethyl)amino]-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142279 CHEMBL324685 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-[2-(furan-3-yl)ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142496 CHEMBL419383 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[hexylsulfonyl(propyl)amino]ethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142189 CHEMBL113087 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-1-[2-[(4-methylphenyl)sulfonyl-propylamino]ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142513 CHEMBL110904 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-[(E)-3-methylpent-3-enyl]pyrrolidine-3-carboxylic acid
CFAMM00142530 CHEMBL368558 Bioactive 2-[(2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidin-3-yl]acetic acid
CFAMM00142305 CHEMBL113472 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-[2-(furan-2-yl)ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142366 CHEMBL320569 Bioactive SureCN14230215
CFAMM00142156 CHEMBL323464 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[butylsulfonyl(propyl)amino]ethyl]-2-(3-fluoro-4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142169 CHEMBL323789 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-1-[2-[2-methylpropyl(propylsulfonyl)amino]ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142182 CHEMBL123316 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[(2,2-dimethyl-1-phenylpropyl)amino]-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid;2,2,2-trifluoroacetic acid
CFAMM00142503 CHEMBL430683 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-[2-(1,3-dithiolan-2-yl)ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142571 CHEMBL320124 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methylpent-3-enyl)pyrrolidine-3-carboxylic acid
CFAMM00142423 CHEMBL427303 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(1,2-diphenylethylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142319 CHEMBL111277 Bioactive SureCN1028842
CFAMM00142134 CHEMBL121647 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-1-[2-[(2-methyl-1-phenylpropyl)amino]-2-oxoethyl]pyrrolidine-3-carboxylic acid;2,2,2-trifluoroacetic acid
CFAMM00142386 CHEMBL123206 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[[(2-ethylphenyl)-(2-methylphenyl)methyl]amino]-2-oxoethyl]-2-[4-(2-propan-2-yloxyethoxy)phenyl]pyrrolidine-3-carboxylic acid;2,2,2-trifluoroacetic acid
CFAMM00142175 CHEMBL109765 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-[butylsulfonyl(propyl)amino]ethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142399 CHEMBL113400 Bioactive (2R,3R,4S)-1-[2-(dibutylamino)-2-oxoethyl]-4-(3,4-difluorophenyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142265 CHEMBL339657 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(2,6-diethylanilino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142278 CHEMBL9313 Bioactive (2S,3S,4R)-4-(1,3-benzodioxol-5-yl)-1-[2-(dipentylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142352 CHEMBL325935 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-[(Z)-pent-3-enyl]pyrrolidine-3-carboxylic acid
CFAMM00142188 CHEMBL111611 Bioactive SureCN14229621
CFAMM00142529 CHEMBL129220 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(3,4-dimethoxyphenyl)pyrrolidine-3-carboxylic acid
CFAMM00142429 CHEMBL322547 Bioactive (2S,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methylpentyl)pyrrolidine-3-carboxylic acid
CFAMM00142605 CHEMBL324639 Bioactive (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-ethoxy-3-fluorophenyl)-1-[2-[pentylsulfonyl(propyl)amino]ethyl]pyrrolidine-3-carboxylic acid
CFAMM00142238 DCL000296 Clinical Trial Drug Atrasentan

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543