CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD201
Family Name C-C chemokine receptor type 5 Ligand GW873140 Family
No. of Seeds 6 No. of Other Members 78
Family Centroid CFAMM00142675 Functional Category Clinical Trial Drug with Natural Product
Superfamily Glucan synthesis regulatory protein Inhibitor Anidulafungin Superfamily
Class Class 322

Cousin Family NamesSeedsMembers
Alpha-1 adrenergic receptor ligand arylethanolamine derivative... 4 37
D(2) dopamine receptor Ligand Remoxipride Family 12 84
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Glucan synthesis regulatory protein Inhibitor Anidulafungin Fa... 2 5
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
HIV-1 protease Inhibitor Lopinavir Family 4 25
Thymopentin family 20 133
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Integrin alpha-4 Inhibitor Firategrast Family 3 93
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
cAMP-dependent protein kinase type II-beta regulatory subunit ... 34 81
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Histamine H3 receptor Ligand A-349821 Family 49 228
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Glucosylceramidase Inhibitor N-(propylamide-benzophenone)-1-de... 2 1
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Pol polyprotein inhibitor 180968-31-4 family 8 13
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 4
Caspase-1 inhibitor 5-(3-carbamoylnaphthalen-2-yl)oxy-3-[[(2S)... 1 11
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 18
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Integrin beta-3 and Integrin alpha-IIb inhibitor (2R)-2-(benze... 4 13
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 6 1
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 4
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-benzylsul... 2 0
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Cytochrome P450 1A2 and Cytochrome P450 3A4 inhibitor 4-[4-[2-... 2 3
Pol polyprotein inhibitor MDL 74538 family 11 1
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 0
NS3 inhibitor Proline-Based Macrocycle 24 family 6 6
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[... 5 5
Peroxisome proliferator-activated receptor gamma ligand (9aS)-... 4 44
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-1-(3,5-d... 10 15
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Beta-secretase 1 and Cathepsin B inhibitor N-[(2S)-1-[[(2S,3R)... 2 1
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 11 15
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 1 16
C-C chemokine receptor type 5 ligand 4-[4-[[4-[(5R)-3-cyclohex... 4 2
Caspase-1 and Caspase-8 inhibitor N-[(6S)-1-[2-[[(3S)-2-hydrox... 3 1
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Pol polyprotein inhibitor SDZ PRI 053 family 8 1
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Pol polyprotein inhibitor AC1LALH8 family 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Growth hormone secretagogue receptor type 1 ligand SureCN76477... 2 1
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 16 2
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 3 1
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Kappa-type opioid receptor ligand N-[(1S)-2-[(3S)-3-hydroxypyr... 2 0
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
Renin inhibitor methyl N-[[5-[[(2S,3S,5R)-2-amino-6-(butylamin... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Cathepsin K inhibitor benzyl N-[(2S)-4-methyl-1-oxo-1-[2-[[(4-... 2 0
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 2 110
C-C chemokine receptor type 3 ligand SureCN3932025 family 1 1
Pol polyprotein inhibitor N-[(2S,3R,4R,5R)-1-cyclohexyl-3,4-di... 3 0
Putative NP ZINC08790868 Family 10 0
NP 2-((5-hydroxy-2,2-dimethyl-4-oxochroman-7-yl)oxy)-n-(3-meth... 18 0
NP 2-((1'-acetyl-4-oxospiro[chroman-2,4'-piperidin]-7-yl)oxy)-... 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00142647 CHEMBL1255794 Bioactive aplaviroc
CFAMM00142628 CHEMBL306897 Bioactive CHEMBL306897
CFAMM00142631 CHEMBL2069616 Bioactive benzyl 4-[4-[[(2S,3S)-1-[[(3S,4S)-1-(butylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]phenoxy]benzoate
CFAMM00142675 DCL000305 Clinical Trial Drug GW873140
CFAMM00142627 DNC000090 Investigative Drug 5-methyl orotate
CFAMM00142650 DNC003861 Investigative Drug PS-154636-1

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543