CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD203
Family Name Arachidonate 5-lipoxygenase Inhibitor MK-591 Family
No. of Seeds 9 No. of Other Members 161
Family Centroid CFAMM00142849 Functional Category Clinical Trial Drug
Superfamily Arachidonate 5-lipoxygenase Inhibitor MK-591 Superfamily
Class Class 958

Cousin Family NamesSeedsMembers
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Indeglitazar family 3 39
Arachidonate 5-lipoxygenase-activating protein Inhibitor AM103... 14 12
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Arachidonate 5-lipoxygenase-activating protein inhibitor SureC... 5 0
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 6
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Cysteinyl leukotriene receptor 1 ligand SureCN9053715 family 2 11
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family 1 30
Cysteinyl leukotriene receptor 1 ligand 3-[1-[3-[(7-chloroquin... 5 6
Neuropeptide Y receptor type 1 ligand SureCN7959195 family 4 4
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 5 12
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-... 4 8
Prostaglandin D2 receptor 2 ligand 2-[3-(4-chlorophenoxy)-5-fl... 3 3
Arachidonate 5-lipoxygenase-activating protein inhibitor SureC... 8 1
Cytochrome P450 3A4 and Cytochrome P450 2D6 inhibitor SureCN16... 8 4
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
Cannabinoid receptor 1 ligand AGN-PC-0766FR family 4 3
Peroxisome proliferator-activated receptor delta and Peroxisom... 7 5
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 1
Wee1-like protein kinase and Serine/threonine-protein kinase C... 8 0
Arachidonate 5-lipoxygenase inhibitor SureCN6008522 family 1 6
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 3
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 7 1
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Prostaglandin E synthase 2 inhibitor AGN-PC-075D2E family 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Peroxisome proliferator-activated receptor gamma and Peroxisom... 9 0
Cysteinyl leukotriene receptor 1 ligand 3-[5-[[3-[(E)-2-(7-chl... 1 1
Arachidonate 5-lipoxygenase-activating protein inhibitor 3-[5-... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 18000... 1 1
Arachidonate 5-lipoxygenase-activating protein inhibitor AGN-P... 1 0
C-C chemokine receptor type 2 ligand AGN-PC-03NT5I family 5 18
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 6 5
Neuropeptide Y receptor type 1 ligand [1-(4-chlorophenoxy)-9-[... 5 7
Phospholipase A2, membrane associated inhibitor 2-(1-benzyl-2-... 2 1
Cysteinyl leukotriene receptor 1 ligand AGN-PC-07C44I family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00142854 CHEMBL316184 Bioactive [1-(4-chlorobenzyl)-2-methyl-5-(quinolin-2-ylmethoxy)-1h-indol-3-yl]acetic acid
CFAMM00142813 CHEMBL297661 Bioactive AGN-PC-00OK0U
CFAMM00142757 CHEMBL78938 Bioactive SureCN9400805
CFAMM00142873 CHEMBL78201 Bioactive 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(5,6,7,8-tetrahydroquinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid
CFAMM00142804 CHEMBL78013 Bioactive SureCN9386857
CFAMM00142878 CHEMBL610469 Bioactive SureCN4203668
CFAMM00142877 CHEMBL31540 Bioactive SureCN2108478
CFAMM00142849 DCL000307 Clinical Trial Drug MK-591
CFAMM00142845 DNC000853 Investigative Drug L-689,037

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21768 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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