CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD204
Family Name Adenosine receptor A2a Ligand KW-6002 Family
No. of Seeds 18 No. of Other Members 195
Family Centroid CFAMM00143102 Functional Category Clinical Trial Drug with Natural Product
Superfamily Adenosine receptor A2a Ligand KW-6002 Superfamily
Class Class 959

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Vardena... 3 39
GP-531 family 1 33
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A2a Ligand (e,e)-8-(4-phenylbutadien-1-yl)c... 11 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 6 14
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SCH-577... 9 29
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN1... 6 16
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 17 3
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-[4-[... 12 15
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Prelamin-A/C inhibitor CHEMBL1501476 family 1 2
Survival motor neuron protein and Microtubule-associated prote... 2 14
Adenosine receptor A1 and Adenosine receptor A3 ligand SureCN5... 3 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
C-X-C chemokine receptor type 3 ligand 3-amino-6-chloro-5-[(3S... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 13 2
Adenosine receptor A2b ligand 2-[5-(2,6-dioxo-1,3-dipropyl-7H-... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
5-hydroxytryptamine receptor 1A and D(4) dopamine receptor lig... 1 0
Adenosine receptor A3 ligand 3-(cyclopropylmethyl)-8-methoxy-1... 1 0
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 10 0
G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... 4 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Collagenase 3 inhibitor 5-[4-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Adenosine receptor A1 and Adenosine receptor A2b ligand (2,5-d... 2 0
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiest... 7 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 2 0
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Adenosine receptor A2b and Adenosine receptor A2a ligand 1-eth... 5 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
Adenosine receptor A1 and Adenosine receptor A2b ligand N-[2-[... 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Sodium- and chloride-dependent glycine transporter 1 and Potas... 14 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
P2X purinoceptor 7 inhibitor (7R)-1-[(3,4-difluorophenyl)methy... 1 0
NP 3-(7-(2,3-dihydroxypropyl)-3-methyl-2,6-dioxo-2,3,6,7-tetra... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00142928 CHEMBL283937 Bioactive (E)-7-Methyl-1,3-dipropyl-8-(2,3,4-trimethoxystyryl)xanthine
CFAMM00143021 CHEMBL316819 Bioactive SureCN13789824
CFAMM00143038 CHEMBL422399 Bioactive (E)-1,3-Diethyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthine
CFAMM00143103 CHEMBL27215 Bioactive (E)-8-(3,5-Dimethoxystyryl)-7-methyl-1,3-dipropylxanthine
CFAMM00143012 CHEMBL2311150 Bioactive MOLI001317
CFAMM00143086 CHEMBL326757 Bioactive 1-[(4-methoxyphenyl)methyl]-3-propylpurino[7,8-a]pyridine-2,4-dione
CFAMM00143018 CHEMBL413079 Bioactive MSX-2
CFAMM00143171 CHEMBL77698 Bioactive (E)-1,3-Diethyl-8-(4-methoxy-2,3-dimethylstyryl)-7-methylxanthine
CFAMM00142992 CHEMBL325777 Bioactive SureCN13789722
CFAMM00143143 CHEMBL1795043 Bioactive 8-[(Z)-2-(3,4-dimethoxyphenyl)ethenyl]-7-methyl-1,3-dipropylpurine-2,6-dione;8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-7-methyl-1,3-dipropylpurine-2,6-dione
CFAMM00142978 CHEMBL306313 Bioactive (E)-7-Methyl-1,3-dipropyl-8-(3,4,5-trimethoxystyryl)xanthine
CFAMM00142964 CHEMBL27508 Bioactive KF-17837
CFAMM00143055 CHEMBL77699 Bioactive (E)-1,3-Diethyl-7-methyl-8-(2,3,4-trimethoxystyryl)xanthine
CFAMM00142998 CHEMBL78317 Bioactive (E)-8-(4-Methoxy-2,3-dimethylstyryl)-7-methyl-1,3-dipropylxanthine
CFAMM00143158 CHEMBL306633 Bioactive (E)-8-(4-Methoxystyryl)-7-methyl-1,3-dipropylxanthine
CFAMM00143102 DCL000312 Clinical Trial Drug KW-6002
CFAMM00142922 DNC004457 Investigative Drug KF-17837
CFAMM00143142 DNC010361 Investigative Drug 8-(3-Methoxybenzyloxy)caffeine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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