CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD206
Family Name Thromboxane A2 receptor Ligand Bibv 308 Family
No. of Seeds 14 No. of Other Members 40
Family Centroid CFAMM00143223 Functional Category Clinical Trial Drug
Superfamily Thromboxane A2 receptor Ligand Bibv 308 Superfamily
Class Class 960

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Thromboxane A2 receptor Ligand Ridogrel Family 7 83
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Histamine H1 receptor Ligand Triprolidine Family 19 316
Histamine H1 receptor Ligand (s)-(+)-dimethindene Maleate Family 6 12
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Prothrombin Inhibitor Ximelegatran Family 8 157
Neuromedin-K receptor Ligand SB222200 Family 17 235
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Coagulation factor X Inhibitor Otamixaban Family 9 21
D(3) dopamine receptor Ligand SB-277011 Family 13 178
JAK Inhibitor Momelotinib Family 33 83
Potassium-competitive acid Inhibitor TAK-438 Family 2 8
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Thromboxane-A synthase Inhibitor CGS-22652 Family 37 95
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Thromboxane A2 receptor and Thromboxane-A synthase ligand AGN-... 4 19
Integrin beta-3 and Integrin alpha-V inhibitor SureCN547914 fa... 8 32
Integrin alpha-V and Integrin beta-5 inhibitor SureCN6563167 f... 2 10
Integrin beta-3 and Integrin alpha-V inhibitor (3R)-3-quinolin... 6 8
Thromboxane-A synthase and Thromboxane A2 receptor ligand (E)-... 2 1
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[6-m... 13 12
Thromboxane A2 receptor and Thromboxane-A synthase ligand 3-[(... 3 0
Thromboxane A2 receptor and Thromboxane-A synthase ligand (E)-... 2 0
Thromboxane-A synthase and Thromboxane A2 receptor ligand (E)-... 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 13 3
B1 bradykinin receptor ligand AGN-PC-005XAO family 3 17
Pol polyprotein inhibitor Lysine Sulfonamide 6h family 1 1
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
G-protein coupled bile acid receptor 1 ligand 1-[4-[(1R,3E)-1-... 1 1
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Thromboxane-A synthase inhibitor 7-[(2S,3R)-3-pyridin-3-yl-2-b... 1 1
Thromboxane-A synthase inhibitor (Z)-2-bromo-3-[4-(pyridin-3-y... 1 0
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-3-[4-[4-[[... 2 0
Cytochrome P450 2C19 inhibitor AGN-PC-07CPMJ family 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-[[2-[3... 4 0
heptanamide NP ZINC08740384 Family 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00143217 CHEMBL21647 Bioactive (E)-6-[3-(tert-butylcarbamoylamino)phenyl]-6-pyridin-3-ylhex-5-enoic acid
CFAMM00143197 CHEMBL21639 Bioactive (E)-6-[3-[(N-cyano-N'-cyclopentylcarbamimidoyl)amino]phenyl]-6-pyridin-3-ylhex-5-enoic acid
CFAMM00143214 CHEMBL282884 Bioactive (E)-6-[3-[(N-cyano-N'-cyclohexylcarbamimidoyl)amino]phenyl]-6-pyridin-3-ylhex-5-enoic acid
CFAMM00143228 CHEMBL21954 Bioactive SureCN9002348
CFAMM00143241 CHEMBL21513 Bioactive (E)-6-[3-[[N-cyano-N'-(2-methylpropyl)carbamimidoyl]amino]phenyl]-6-pyridin-3-ylhex-5-enoic acid
CFAMM00143234 CHEMBL21570 Bioactive (E)-6-[3-[[1-(tert-butylamino)-2,2-dicyanoethenyl]amino]phenyl]-6-pyridin-3-ylhex-5-enoic acid
CFAMM00143193 CHEMBL21478 Bioactive (E)-7-[3-[(N'-tert-butyl-N-cyanocarbamimidoyl)amino]phenyl]-7-pyridin-3-ylhept-6-enoic acid
CFAMM00143206 CHEMBL21303 Bioactive SureCN9002346
CFAMM00143199 CHEMBL21476 Bioactive (E)-8-[3-[(N'-tert-butyl-N-cyanocarbamimidoyl)amino]phenyl]-8-pyridin-3-yloct-7-enoic acid
CFAMM00143239 CHEMBL22023 Bioactive 5-[(E)-[[3-[(N'-tert-butyl-N-cyanocarbamimidoyl)amino]phenyl]-pyridin-3-ylmethylidene]amino]oxypentanoic acid
CFAMM00143218 CHEMBL21852 Bioactive (E)-6-[3-[[N'-(1-adamantyl)-N-cyanocarbamimidoyl]amino]phenyl]-6-pyridin-3-ylhex-5-enoic acid
CFAMM00143245 CHEMBL416374 Bioactive (E)-6-[3-[[N-cyano-N'-(3-methylbutyl)carbamimidoyl]amino]phenyl]-6-pyridin-3-ylhex-5-enoic acid
CFAMM00143211 CHEMBL7718 Bioactive (Z)-6-[3-[(N'-tert-butyl-N-cyanocarbamimidoyl)amino]phenyl]-6-pyridin-3-ylhex-5-enoic acid
CFAMM00143223 DCL000316 Clinical Trial Drug BIBV 308

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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