CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD207
Family Name Thromboxane A2 receptor Ligand Ramatroban Family
No. of Seeds 13 No. of Other Members 49
Family Centroid CFAMM00143283 Functional Category Clinical Trial Drug
Superfamily Thromboxane A2 receptor and Potassium-competitive acid Binder Superfamily
Class Class 8

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
Prostaglandin E2 receptor EP3 subtype Ligand DG041 Family 9 16
5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66
Prostaglandin D2 receptor 2 Ligand AZD1981 Family 11 28
Histone deacetylase 1 Inhibitor Resminostat Family 2 5
E7820 family 9 56
Potassium-competitive acid Inhibitor TAK-438 Family 2 8
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 3 11
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
Thromboxane A2 receptor and Thromboxane-A synthase ligand AGN-... 4 19
Motilin receptor and Cytochrome P450 2D6 ligand 7-[[6-(4-chlor... 2 1
Protein kinase C theta type and Protein kinase C delta type in... 7 17
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Thromboxane-A synthase inhibitor AGN-PC-00N7V2 family 3 6
Cannabinoid receptor 2 ligand AGN-PC-09M5PW family 12 2
Cannabinoid receptor 2 ligand 1,1,1-trifluoro-N-[(1R)-1-[4-[1-... 2 1
Cannabinoid receptor 2 ligand 1,1,1-trifluoro-N-[(2S)-6-(1-pyr... 2 1
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 8
Prostaglandin D2 receptor 2 ligand 2-[(8R)-8-[(4-fluorophenyl)... 3 15
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 20 37
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 5 2
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 4 0
Prostaglandin D2 receptor 2 ligand SureCN2189431 family 7 1
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Prostaglandin D2 receptor 2 ligand 2-[5-fluoro-2-methyl-3-[(4-... 3 5
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Prostaglandin D2 receptor 2 ligand SureCN317401 family 3 8
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-6-br... 5 1
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 2 0
Prostaglandin D2 receptor 2 and Cytochrome P450 2C19 ligand 2-... 6 13
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
Prostaglandin D2 receptor 2 ligand 2-[3-[(E)-2-cyano-3-(N-meth... 9 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Thromboxane A2 receptor and Thromboxane-A synthase ligand AGN-... 2 3
5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0
5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0
Thromboxane A2 receptor ligand 3-[5-[(4-chlorophenyl)sulfonyla... 1 0
Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1
Prostaglandin D2 receptor 2 ligand SureCN2516080 family 1 0
5-hydroxytryptamine receptor 6 ligand 2-[[(1Z)-1-[5-(benzenesu... 1 0
5-hydroxytryptamine receptor 6 ligand 4-bromo-N-[3-[[(2S)-1-me... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00143274 CHEMBL47612 Bioactive SureCN8539221
CFAMM00143287 CHEMBL373118 Bioactive 3-[(3R)-3-[(4-fluorophenyl)sulfonyl-methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid
CFAMM00143273 CHEMBL359855 Bioactive AGN-PC-009EL6
CFAMM00143271 CHEMBL298483 Bioactive 9H-Carbazole-9-propanoicacid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-
CFAMM00143291 CHEMBL43768 Bioactive 3-[5-[(4-fluorophenyl)sulfonylamino]indol-1-yl]propanoic acid
CFAMM00143306 CHEMBL179036 Bioactive 2-[(3R)-3-[(4-fluorophenyl)sulfonyl-methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid
CFAMM00143263 CHEMBL47372 Bioactive 3-[3-[(4-fluorophenyl)methyl]-5-[(4-methylphenyl)sulfonylamino]indol-1-yl]propanoic acid
CFAMM00143305 CHEMBL1643768 Bioactive CAY10471
CFAMM00143262 CHEMBL44660 Bioactive 3-[5-(benzenesulfonamido)-3-[(4-fluorophenyl)methyl]indol-1-yl]propanoic acid
CFAMM00143289 CHEMBL194085 Bioactive 2-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid
CFAMM00143282 CHEMBL48128 Bioactive 3-[3-[(4-fluorophenyl)methyl]-5-[(4-fluorophenyl)sulfonylamino]indol-1-yl]propanoic acid
CFAMM00143279 DCL000880 Clinical Trial Drug MEM-3454
CFAMM00143283 DCL000318 Clinical Trial Drug Ramatroban

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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