CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD210
Family Name Cannabinoid receptor 1 Ligand Taranabant Family
No. of Seeds 20 No. of Other Members 30
Family Centroid CFAMM00143325 Functional Category Clinical Trial Drug
Superfamily Cannabinoid receptor 1 Ligand Taranabant Superfamily
Class Class 963

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Substance-P receptor ligand (1S,2R)-2-[(1R)-1-[3,5-bis(trifluo... 7 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(2-methoxy-3-methylpy... 2 3
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Survival motor neuron protein and Lysine-specific demethylase ... 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
G-protein coupled bile acid receptor 1 ligand 4-[[3,5-bis(trif... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 4 5
P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... 4 14
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Transient receptor potential cation channel subfamily V member... 6 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 4-[[2... 2 0
Renin inhibitor SureCN6042213 family 2 3
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Sodium-dependent serotonin transporter and Neuropeptide Y rece... 1 0
Lysophosphatidic acid receptor 1 and Lysophosphatidic acid rec... 3 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 4 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00143362 CHEMBL373626 Bioactive SureCN13140599
CFAMM00143355 CHEMBL226590 Bioactive N-[(2S,3S)-3-(3-cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butan-2-yl]-2-methyl-2-(4-methylpyridin-2-yl)oxypropanamide
CFAMM00143320 CHEMBL226642 Bioactive UNII-GB3CX2BG84
CFAMM00143334 CHEMBL387526 Bioactive N-[(2S,3S)-3-(3-cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butan-2-yl]-2-(5-cyanopyridin-2-yl)oxy-2-methylpropanamide
CFAMM00143327 CHEMBL226589 Bioactive 2-(5-chloropyridin-2-yl)oxy-N-[(2S,3S)-3-(3-cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butan-2-yl]-2-methylpropanamide
CFAMM00143354 CHEMBL226591 Bioactive UNII-3XCL8256SA
CFAMM00143367 CHEMBL260977 Bioactive N-[(2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)butan-2-yl]-2-methyl-2-(5-methylpyridin-2-yl)oxypropanamide
CFAMM00143333 CHEMBL374791 Bioactive N-[(2S,3S)-4-(4-chlorophenyl)-3-phenylbutan-2-yl]-2-methyl-2-pyridin-2-yloxypropanamide
CFAMM00143347 CHEMBL1209596 Bioactive N-[(2S,3S)-3-(3-bromophenyl)-4-(4-chlorophenyl)butan-2-yl]-2-methyl-2-[5-(trifluoromethyl)pyridin-2-yl]oxypropanamide
CFAMM00143340 CHEMBL376767 Bioactive N-[(2S,3S)-3-(3-cyano-5-fluorophenyl)-4-[4-(2-fluoroethoxy)phenyl]butan-2-yl]-2-methyl-2-[5-(trifluoromethyl)pyridin-2-yl]oxypropanamide
CFAMM00143318 CHEMBL376794 Bioactive N-[(2S,3S)-3-(3-cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butan-2-yl]-2-methyl-2-[4-(trifluoromethyl)pyridin-2-yl]oxypropanamide
CFAMM00143332 CHEMBL226684 Bioactive N-[(2S,3S)-3-(3-cyano-5-fluorophenyl)-4-(4-methoxyphenyl)butan-2-yl]-2-methyl-2-[5-(trifluoromethyl)pyridin-2-yl]oxypropanamide
CFAMM00143359 CHEMBL387027 Bioactive SureCN13114227
CFAMM00143352 CHEMBL226534 Bioactive N-[(2S,3S)-3-(3-cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butan-2-yl]-2-methyl-2-[5-(trifluoromethyl)pyridin-2-yl]oxypropanamide
CFAMM00143365 CHEMBL227329 Bioactive N-[(2S,3S)-3-(3-cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butan-2-yl]-2-methyl-2-pyridin-2-yloxypropanamide
CFAMM00143331 CHEMBL226685 Bioactive N-[(2S,3S)-3-(3-cyano-5-fluorophenyl)-4-[4-(fluoromethoxy)phenyl]butan-2-yl]-2-methyl-2-[5-(trifluoromethyl)pyridin-2-yl]oxypropanamide
CFAMM00143338 CHEMBL468313 Bioactive SureCN501972
CFAMM00143343 CHEMBL513814 Bioactive SureCN1898233
CFAMM00143356 CHEMBL231636 Bioactive N-[(2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)butan-2-yl]-2-methyl-2-[5-(trifluoromethyl)pyridin-3-yl]oxypropanamide
CFAMM00143325 DCL000327 Clinical Trial Drug Taranabant

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21760 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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