CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD217
Family Name D(2) dopamine receptor Ligand Nomifensine Family
No. of Seeds 6 No. of Other Members 100
Family Centroid CFAMM00143856 Functional Category Clinical Trial Drug
Superfamily D(2) dopamine receptor Ligand Nomifensine Superfamily
Class Class 967

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Calmodulin Inhibitor Aprindine Family 1 4
Histamine H1 receptor Ligand Epinastine Family 2 26
Histamine H1 receptor Ligand Antazoline Family 5 57
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Amonafide family 3 35
WAY-162545 family 2 4
NMDA receptor Ligand Aptiganel Hcl Family 2 82
5-hydroxytryptamine receptor 6 Ligand 4-(1h-inden-1-ylmethyl)-... 5 99
Potassium voltage-gated channel subfamily A member 3 Ligand CP... 4 26
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3,... 3 4
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 8 32
Androgen receptor Ligand YM-175735 Family 30 129
Aromatase Inhibitor 3-amino-4'-amino-trans-stilbene Family 5 47
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
Histamine H3 receptor Ligand (r)-1-(4-nitrophenethyl)-2-methyl... 16 38
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
Acetylcholinesterase Inhibitor (3-hydroxy-2-methyl-phenyl)-tri... 4 25
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 4
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-[1-adama... 4 23
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
5-hydroxytryptamine receptor 7 ligand 1-[2-(4-nitrophenyl)phen... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 4
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand 4-[(... 2 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Androgen receptor ligand 4-[(1R,5R)-3-hydroxy-3-methyl-8-azabi... 8 7
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 1 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRYI family 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 3 5
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 12
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
Lysosomal Pro-X carboxypeptidase and Glutamate receptor ionotr... 1 0
Squalene monooxygenase inhibitor 3-[[[(E)-6,6-dimethylhept-2-e... 1 0
Cholinesterase inhibitor 10-[[(1R,9aR)-2,3,4,6,7,8,9,9a-octahy... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 4
Alkaloids and Derivatives Metabolite (+)-Aspidospermidine Family 1 5
Acenes Metabolite 1-Aminopyrene Family 1 63
(5,7-dimethyl-1,3-diazatricyclo[3.3.1.1~3,7~]dec-2-yl)aniline ... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00143811 CHEMBL1256842 Bioactive Nomifensine maleate
CFAMM00143856 DCL000339 Clinical Trial Drug Nomifensine
CFAMM00143836 DNC003579 Investigative Drug 1-Naphthalen-1-yl-piperazine
CFAMM00143875 DNC009269 Investigative Drug (R)-2,11-Diaminoaporphine
CFAMM00143854 DNC007749 Investigative Drug 3-butyl-1-(naphthalen-1-yl)piperidin-4-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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