CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD220
Family Name Fibroblast growth factor receptor 1 and Aurora kinase B Inhibitor SU-6668 Family
No. of Seeds 4 No. of Other Members 51
Family Centroid CFAMM00143942 Functional Category Clinical Trial Drug with Human Metabolite
Superfamily Fibroblast growth factor receptor 1 and Aurora kinase B Inhibitor SU-6668 Superfamily
Class Class 78

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Prostaglandin G/H synthase 2 Inhibitor Carprofen Family 1 5
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
porphyrin Haem arginate Family 5 11
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Substance-P receptor Ligand GSK424887 Family 8 184
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 16 0
Heme oxygenase 1 Inhibitor Tin Protoporphyrin Family 2 12
AP endonuclease APE1 Inhibitor 5-fluoro-1h-indole-2-carboxylic... 2 61
Heme oxygenase 1 Inhibitor Verdoheme Family 2 0
Tyrosine-protein phosphatase non-receptor type 1 Ligand 6-(oxa... 1 5
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Vascular endothelial growth factor receptor 2 Ligand Isoindoli... 11 36
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... 10 26
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Kinesin-like protein KIF11 Inhibitor Methyl 7-tert-butyl-9h-ca... 2 9
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Endothelin B receptor Ligand IRL-2500 Family 34 87
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Histone deacetylase Inhibitor ST-5732 Family 8 6
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 3 4
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 4 4
Aurora kinase A and Aurora kinase B inhibitor SureCN3802769 fa... 2 20
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
NS5B protein inhibitor AGN-PC-00A17Z family 1 23
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 3 6
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
RAC-beta serine/threonine-protein kinase inhibitor SureCN57283... 2 0
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 1
Leucine-rich repeat serine/threonine-protein kinase 2 and Plat... 1 0
High affinity nerve growth factor receptor ligand CHEMBL254555... 2 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 4
Hepatocyte growth factor receptor and Protein-tyrosine kinase ... 2 15
Protein kinase C delta type and Protein kinase C beta type inh... 4 4
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 7 18
Cyclin-dependent kinase 2 and Vascular endothelial growth fact... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
Kinesin-like protein KIF11 inhibitor 9-(trifluoromethyl)-1,2,4... 4 1
Vascular endothelial growth factor receptor 2 ligand 3-[2-[(Z)... 1 3
Glycogen synthase kinase 3 beta and Dual specificity tyrosine-... 1 6
Insulin receptor ligand 2,5-dihydroxy-3-(1H-indol-3-yl)-6-phen... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 48
2,2-dimethyl-3-(2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-ca... 4 0
NP Agn-pc-099dao Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00143980 CHEMBL149201 Bioactive SU 16F
CFAMM00143942 DCL000342 Clinical Trial Drug SU-6668
CFAMM00143979 DNC001229 Investigative Drug Robalzotan monohydrobromide
CFAMM00143984 DNC009371 Investigative Drug NP-506

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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