CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD223
Family Name Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2 Inhibitor HKI-272 Family
No. of Seeds 16 No. of Other Members 89
Family Centroid CFAMM00144324 Functional Category Clinical Trial Drug
Superfamily Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2 Inhibitor HKI-272 Superfamily
Class Class 970

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
Tivozanib family 4 6
AP26113 family 16 90
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 7
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Vascular endothelial growth factor receptor 2 and Vascular end... 3 3
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Platelet-derived growth factor receptor beta and Receptor-type... 1 2
Proto-oncogene tyrosine-protein kinase Src inhibitor AGN-PC-07... 17 9
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS94Q ... 6 0
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 10 4
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00144401 CHEMBL1243346 Bioactive SureCN12641776
CFAMM00144407 CHEMBL1243254 Bioactive SureCN2028432
CFAMM00144374 CHEMBL1243284 Bioactive (E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-(2-fluoroethoxy)quinolin-6-yl]-4-(methylamino)but-2-enamide
CFAMM00144406 CHEMBL1243255 Bioactive SureCN4965393
CFAMM00144325 CHEMBL607707 Bioactive Pelitinib
CFAMM00144419 CHEMBL2031308 Bioactive N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-3-piperidin-1-ylpropanamide
CFAMM00144418 CHEMBL2031309 Bioactive N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-3-morpholin-4-ylpropanamide
CFAMM00144363 CHEMBL179363 Bioactive (E)-N-[4-[3-chloro-4-[(3-chlorophenyl)methoxy]anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
CFAMM00144424 CHEMBL1243345 Bioactive (E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-[2-fluoroethyl(methyl)amino]but-2-enamide
CFAMM00144417 CHEMBL2031306 Bioactive N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]prop-2-enamide
CFAMM00144410 CHEMBL1243316 Bioactive (E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(prop-2-ynylamino)but-2-enamide
CFAMM00144416 CHEMBL2031307 Bioactive N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-3-(dimethylamino)propanamide
CFAMM00144355 CHEMBL360519 Bioactive (E)-N-[4-[3-chloro-4-[(2-chlorophenyl)methoxy]anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
CFAMM00144375 CHEMBL1243283 Bioactive SureCN12641755
CFAMM00144388 CHEMBL359629 Bioactive (E)-N-[4-[3-chloro-4-(naphthalen-1-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
CFAMM00144324 DCL000346 Clinical Trial Drug HKI-272

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543