CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD232
Family Name Platelet-derived growth factor receptor Ligand CP-868596 Family
No. of Seeds 3 No. of Other Members 91
Family Centroid CFAMM00144610 Functional Category Clinical Trial Drug
Superfamily Platelet-derived growth factor receptor Ligand CP-868596 Superfamily
Class Class 976

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
SB1518 family 7 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Serine/threonine-protein kinase Chk2 Inhibitor 5-nitro-2-(4-ph... 6 3
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phen... 2 9
Melanin-concentrating hormone receptor 1 Ligand ADS-103214 Family 3 4
D(4) dopamine receptor Ligand A-425444 Family 2 10
Platelet-derived growth factor receptor beta and Ephrin type-B... 9 16
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Platelet-derived growth factor receptor beta and Platelet-deri... 2 19
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Neuropeptide Y receptor type 5 and Alpha-1A adrenergic recepto... 8 2
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Neuropeptide Y receptor type 1 ligand 2-[(4-chlorophenoxy)meth... 5 13
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Transient receptor potential M8 protein ligand (3E)-3-[5-[2-(t... 4 2
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Melanin-concentrating hormone receptor 1 ligand SureCN3334861 ... 1 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 3
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Corticotropin-releasing factor receptor 1 ligand 6-ethyl-3-met... 6 10
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 15
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 16 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 5 8
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11
Mu-type opioid receptor and Nitric oxide synthase, brain ligan... 3 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Glutamate receptor ionotropic, NMDA 2B ligand 2-[[4-(4-chlorop... 4 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Histamine H4 receptor ligand AGN-PC-00FEQJ family 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 4
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Angiopoietin-1 receptor and Vascular endothelial growth factor... 2 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 0
Collagenase 3 inhibitor 5-[4-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 2 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Sterol O-acyltransferase 1 inhibitor 1-[4-[2-(4,5-diphenyl-1H-... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 5
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
D(2) dopamine receptor ligand SureCN11039666 family 1 4
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Transient receptor potential cation channel subfamily V member... 18 1
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
5-hydroxytryptamine receptor 1A and Gonadotropin-releasing hor... 3 0
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Cholecystokinin receptor type A ligand SureCN3132309 family 11 0
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Metabotropic glutamate receptor 2 ligand 2-[[(1R,5S)-6-[(2,5-d... 2 3
5-hydroxytryptamine receptor 1A ligand AGN-PC-04UH85 family 2 3
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor 3-(2-chloro-6-m... 4 6
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919280 f... 23 18
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00FHC0 f... 2 0
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2-(dimethyla... 2 1
Coagulation factor X inhibitor AGN-PC-07C2VY family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00144631 CHEMBL25484 Bioactive 3-[(E)-3-[5-(1-ethanimidoylpiperidin-4-yl)oxy-2-ethylbenzimidazol-1-yl]prop-1-enyl]aniline
CFAMM00144635 CHEMBL24460 Bioactive 3-[(E)-3-[6-(1-ethanimidoylpiperidin-4-yl)oxy-2-ethylbenzimidazol-1-yl]prop-1-enyl]aniline
CFAMM00144610 DCL000359 Clinical Trial Drug CP-868596

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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