CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD235
Family Name Dual specificity mitogen-activated protein kinase kinase Inhibitor PD-0325901 Family
No. of Seeds 5 No. of Other Members 13
Family Centroid CFAMM00144820 Functional Category Clinical Trial Drug
Superfamily Dual specificity mitogen-activated protein kinase kinase Inhibitor PD-0325901 Superfamily
Class Class 311

Cousin Family NamesSeedsMembers
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Dual specificity mitogen-activated protein kinase kinase Inhib... 8 4
Pan-DAC Inhibitor AR-42 Family 21 153
Mitogen-activated protein kinase kinase kinase 1 and Mitogen-a... 1 0
Fumarate reductase flavoprotein subunit Inhibitor 2-heptyl-4-h... 3 16
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Transient receptor potential cation channel subfamily V member... 1 5
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(2,4... 3 6
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(3-cyanophe... 7 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00144824 CHEMBL1614766 Bioactive RO4987655
CFAMM00144834 CHEMBL2335186 Bioactive 2-(4-bromo-2-fluoroanilino)-3,4-difluoro-N-(2-hydroxyethoxy)benzamide
CFAMM00144826 CHEMBL244488 Bioactive 3,4-difluoro-2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)benzamide
CFAMM00144833 CHEMBL450775 Bioactive N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide
CFAMM00144820 DCL000363 Clinical Trial Drug PD-0325901

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21760 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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