CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD238
Family Name Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-protein kinase Src Inhibitor AZD0530 Family
No. of Seeds 25 No. of Other Members 40
Family Centroid CFAMM00145246 Functional Category Clinical Trial Drug
Superfamily Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-protein kinase Src Inhibitor AZD0530 Superfamily
Class Class 386

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Tyrosine-protein kinase SYK Inhibitor R788 Family 3 7
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
AP26113 family 16 90
SB1518 family 7 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Varlitinib family 2 8
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Proto-oncogene tyrosine-protein kinase Src inhibitor N-(2,4-di... 3 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 10 54
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Receptor-type tyrosine-protein kinase FLT3 ligand 2-(6,7-dimet... 3 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Vascular endothelial growth factor receptor 2 and Vascular end... 3 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 3 1
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
ALK tyrosine kinase receptor and Insulin-like growth factor 1 ... 1 4
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 14 2
Aurora kinase A inhibitor SureCN4289024 family 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Histone-lysine N-methyltransferase EHMT2 inhibitor N-(1-cyclop... 1 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
Transient receptor potential cation channel subfamily V member... 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-amin... 4 3
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
Ephrin type-B receptor 4 ligand AGN-PC-077MSC family 4 15
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
cGMP-specific 3',5'-cyclic phosphodiesterase and cAMP-specific... 1 3
1-acyl-sn-glycerol-3-phosphate acyltransferase beta inhibitor ... 1 2
Ephrin type-B receptor 4 ligand AGN-PC-077MSZ family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00145222 CHEMBL214665 Bioactive AZD0530 analogue 6
CFAMM00145241 CHEMBL217090 Bioactive AZD0530 analogue 15
CFAMM00145221 CHEMBL198752 Bioactive AGN-PC-075YDP
CFAMM00145200 CHEMBL217463 Bioactive N-(5-chloro-1,3-benzodioxol-4-yl)-5-(oxan-4-yloxy)-7-(2-pyridin-4-ylethoxy)quinazolin-4-amine
CFAMM00145227 CHEMBL424664 Bioactive AGN-PC-075Y9P
CFAMM00145240 CHEMBL422564 Bioactive Benzodioxole deriv. 25
CFAMM00145232 CHEMBL214376 Bioactive AGN-PC-00J1TW
CFAMM00145198 CHEMBL217464 Bioactive AZD0530 analogue 28
CFAMM00145212 CHEMBL216703 Bioactive AZD0530 analogue 9
CFAMM00145218 CHEMBL200231 Bioactive AGN-PC-075YEP
CFAMM00145231 CHEMBL170984 Bioactive Chlorobenzodioxole deriv. 27
CFAMM00145245 CHEMBL385723 Bioactive AZD0530 analogue 37
CFAMM00145197 CHEMBL436968 Bioactive AZD0530 analogue 31
CFAMM00145237 CHEMBL216693 Bioactive AZD0530 analogue 25
CFAMM00145211 CHEMBL354145 Bioactive Chlorobenzodioxole deriv. 29
CFAMM00145204 CHEMBL262371 Bioactive AZD0530 analogue 21
CFAMM00145217 CHEMBL213762 Bioactive AZD0530 analogue 29
CFAMM00145210 CHEMBL385563 Bioactive AZD0530 analogue 16
CFAMM00145236 CHEMBL200217 Bioactive AZD0530 analogue 7
CFAMM00145202 CHEMBL216105 Bioactive AZD0530 analogue 18
CFAMM00145242 CHEMBL217091 Bioactive N-(5-chloro-1,3-benzodioxol-4-yl)-7-methoxy-5-pyridin-4-yloxyquinazolin-4-amine
CFAMM00145195 CHEMBL371688 Bioactive AGN-PC-075YAM
CFAMM00145209 CHEMBL369360 Bioactive Benzodioxole deriv. 19
CFAMM00145246 DCL000368 Clinical Trial Drug AZD0530

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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