CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD239
Family Name Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-protein kinase Src Inhibitor Bosutinib Family
No. of Seeds 67 No. of Other Members 130
Family Centroid CFAMM00145414 Functional Category Clinical Trial Drug
Superfamily Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-protein kinase Src Inhibitor Bosutinib Superfamily
Class Class 970

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Epidermal growth factor receptor and Receptor tyrosine-protein... 16 89
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Tivozanib family 4 6
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Epidermal growth factor receptor and Abelson tyrosine-protein ... 6 3
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Proto-oncogene tyrosine-protein kinase Src inhibitor N-(2,4-di... 3 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 7
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Vascular endothelial growth factor receptor 2 and Vascular end... 3 3
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Proto-oncogene tyrosine-protein kinase Src inhibitor 4-(2,3-di... 2 1
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
Proto-oncogene tyrosine-protein kinase Src inhibitor AGN-PC-07... 17 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS94Q ... 6 0
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN4... 9 2
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
Hepatocyte growth factor receptor ligand 1-(2-chlorophenyl)-N-... 14 8
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00145389 CHEMBL100825 Bioactive AC1NS95W
CFAMM00145304 CHEMBL290921 Bioactive 4-phenylamino-3-quinolinecarbonitrile 7
CFAMM00145317 CHEMBL240830 Bioactive SureCN4963122
CFAMM00145428 CHEMBL131725 Bioactive AC1NS5OA
CFAMM00145310 CHEMBL67812 Bioactive 3-quinolinecarbonitrile deriv. 26
CFAMM00145370 CHEMBL41465 Bioactive 622368-88-1
CFAMM00145395 CHEMBL124333 Bioactive 3-quinolinecarbonitrile 13
CFAMM00145316 CHEMBL211647 Bioactive AGN-PC-00E3QN
CFAMM00145261 CHEMBL334364 Bioactive AC1NS5PM
CFAMM00145440 CHEMBL240413 Bioactive SureCN4963092
CFAMM00145454 CHEMBL445319 Bioactive AGN-PC-0763RJ
CFAMM00145407 CHEMBL1088372 Bioactive SureCN4132977
CFAMM00145433 CHEMBL584054 Bioactive AGN-PC-07CQQN
CFAMM00145276 CHEMBL100651 Bioactive AC1NS5N4
CFAMM00145446 CHEMBL198650 Bioactive AC1NS94K
CFAMM00145302 CHEMBL130242 Bioactive AC1NS5OY
CFAMM00145348 CHEMBL1087215 Bioactive 4-(2,4-dichloro-5-methoxyanilino)-7-[(E)-2-[5-[(dimethylamino)methyl]pyridin-2-yl]ethenyl]-6-methoxyquinoline-3-carbonitrile
CFAMM00145375 CHEMBL424262 Bioactive AC1NS5PP
CFAMM00145328 CHEMBL129968 Bioactive AC1NS5Q4
CFAMM00145260 CHEMBL128612 Bioactive AC1NS5OV
CFAMM00145413 CHEMBL103627 Bioactive AC1NS95H
CFAMM00145426 CHEMBL1088680 Bioactive SureCN4123793
CFAMM00145354 CHEMBL307087 Bioactive ethenyl-4-phenylamino-3-quinolinecarbonitrile 2a
CFAMM00145334 CHEMBL584915 Bioactive SureCN3224349
CFAMM00145347 CHEMBL322395 Bioactive AC1NS95T
CFAMM00145288 CHEMBL42136 Bioactive 622368-91-6
CFAMM00145374 CHEMBL102727 Bioactive AC1NS96E
CFAMM00145432 CHEMBL239140 Bioactive SureCN4962564
CFAMM00145425 CHEMBL1088681 Bioactive SureCN4116887
CFAMM00145353 CHEMBL211079 Bioactive AGN-PC-0763PZ
CFAMM00145452 CHEMBL569073 Bioactive SureCN3264813
CFAMM00145294 CHEMBL1087216 Bioactive 4-(2,4-dichloro-5-methoxyanilino)-7-[(E)-2-[6-[(dimethylamino)methyl]pyridin-2-yl]ethenyl]-6-methoxyquinoline-3-carbonitrile
CFAMM00145307 CHEMBL69230 Bioactive ethenyl-4-phenylamino-3-quinolinecarbonitrile 2b
CFAMM00145367 CHEMBL338194 Bioactive AC1NS5PG
CFAMM00145265 CHEMBL40557 Bioactive 4-phenylamino-3-quinolinecarbonitrile 10
CFAMM00145274 CHEMBL567875 Bioactive SureCN3221031
CFAMM00145333 CHEMBL1088240 Bioactive SureCN4123285
CFAMM00145346 CHEMBL128158 Bioactive AC1NS5PD
CFAMM00145385 CHEMBL1087834 Bioactive 4-(2,4-dichloro-5-methoxyanilino)-7-[(E)-2-[3-[(dimethylamino)methyl]phenyl]ethenyl]-6-methoxyquinoline-3-carbonitrile
CFAMM00145313 CHEMBL1087340 Bioactive 4-(2,4-dichloro-5-methoxyanilino)-7-[(E)-2-[4-[(dimethylamino)methyl]phenyl]ethenyl]-6-methoxyquinoline-3-carbonitrile
CFAMM00145398 CHEMBL317821 Bioactive AC1NS96B
CFAMM00145267 CHEMBL212818 Bioactive AGN-PC-0763PD
CFAMM00145280 CHEMBL340914 Bioactive AGN-PC-075JV8
CFAMM00145391 CHEMBL129143 Bioactive AC1NS5PA
CFAMM00145306 CHEMBL122744 Bioactive AC1NS5MV
CFAMM00145264 CHEMBL340350 Bioactive AC1NS5Q1
CFAMM00145417 CHEMBL103454 Bioactive 4-Anilino-7-phenyl-3-quinolinecarbonitrile 15k
CFAMM00145332 CHEMBL1088241 Bioactive SureCN4127009
CFAMM00145345 CHEMBL1087212 Bioactive 4-(2,4-dichloro-5-methoxyanilino)-7-[(E)-2-[4-[(dimethylamino)methyl]pyridin-2-yl]ethenyl]-6-methoxyquinoline-3-carbonitrile
CFAMM00145384 CHEMBL338413 Bioactive 3-quinolinecarbonitrile 8
CFAMM00145443 CHEMBL214346 Bioactive AGN-PC-0763RY
CFAMM00145286 CHEMBL1087978 Bioactive SureCN4128217
CFAMM00145358 CHEMBL339893 Bioactive AC1NS5OS
CFAMM00145397 CHEMBL1088679 Bioactive SureCN4127017
CFAMM00145410 CHEMBL212629 Bioactive AGN-PC-0763PY
CFAMM00145351 CHEMBL214308 Bioactive AGN-PC-0763SP
CFAMM00145305 CHEMBL211417 Bioactive AGN-PC-0763SB
CFAMM00145429 CHEMBL130529 Bioactive SureCN676420
CFAMM00145272 CHEMBL181408 Bioactive AC1NS99T
CFAMM00145344 CHEMBL378484 Bioactive AGN-PC-0763QI
CFAMM00145263 CHEMBL211613 Bioactive AGN-PC-0763QJ
CFAMM00145285 CHEMBL178787 Bioactive AC1NS99W
CFAMM00145456 CHEMBL128326 Bioactive AC1NS5PJ
CFAMM00145371 CHEMBL194969 Bioactive AC1NS93T
CFAMM00145409 CHEMBL240207 Bioactive SureCN4963012
CFAMM00145414 DCL000369 Clinical Trial Drug Bosutinib
CFAMM00145378 DNC013430 Investigative Drug SKS-927

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543