CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK256066 Family
No. of Seeds 15 No. of Other Members 18
Family Centroid CFAMM00145568 Functional Category Clinical Trial Drug
Superfamily cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK256066 Superfamily
Class Class 979

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Serine/threonine-protein kinase PLK1 Inhibitor HMN-214 Family 3 58
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Apricoxib family 8 77
Indeglitazar family 3 39
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Histamine H3 receptor ligand SureCN2784306 family 5 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Proto-oncogene tyrosine-protein kinase receptor Ret ligand GW5... 1 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854955 f... 2 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Collagenase 3 and Disintegrin and metalloproteinase domain-con... 1 2
Matrix metalloproteinase-9 and Collagenase 3 inhibitor N-hydro... 2 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4
Disintegrin and metalloproteinase domain-containing protein 17... 9 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 5
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 2
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 2 3
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 14 2
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 2 3


External ID

Functional Category

Molecule Name

CFAMM00145603 CHEMBL515240 Bioactive 6-(benzenesulfonyl)-4-(3-methoxyanilino)quinoline-3-carboxamide
CFAMM00145576 CHEMBL517766 Bioactive 4-(2,3-dihydro-1-benzofuran-4-ylamino)-6-methylsulfonylquinoline-3-carboxamide
CFAMM00145565 CHEMBL515098 Bioactive 4-(4-fluoro-3-methoxyanilino)-8-methoxy-6-methylsulfonylquinoline-3-carboxamide
CFAMM00145601 CHEMBL570029 Bioactive 6-[4-(furan-3-yl)phenyl]sulfonyl-4-(3-methoxyanilino)quinoline-3-carboxamide
CFAMM00145573 CHEMBL584327 Bioactive 6-(benzenesulfonyl)-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide
CFAMM00145591 CHEMBL585937 Bioactive 6-cyclopentylsulfonyl-4-(3-methoxyanilino)quinoline-3-carboxamide
CFAMM00145563 CHEMBL462150 Bioactive 4-(3-methoxyanilino)-6-methylsulfonylquinoline-3-carboxamide
CFAMM00145581 CHEMBL473764 Bioactive 4-(4-fluoro-3-methoxyanilino)-8-methyl-6-methylsulfonylquinoline-3-carboxamide
CFAMM00145598 CHEMBL571593 Bioactive 4-(3-methoxyanilino)-6-morpholin-4-ylsulfonylquinoline-3-carboxamide
CFAMM00145606 CHEMBL571381 Bioactive 4-(3-methoxyanilino)-6-(4-methoxyphenyl)sulfonyl-8-methylquinoline-3-carboxamide
CFAMM00145587 CHEMBL569556 Bioactive 4-(3-methoxyanilino)-6-(4-methoxyphenyl)sulfonylquinoline-3-carboxamide
CFAMM00145597 CHEMBL571171 Bioactive 6-(4-tert-butylphenyl)sulfonyl-4-(3-methoxyanilino)quinoline-3-carboxamide
CFAMM00145577 CHEMBL576479 Bioactive 6-(dimethylsulfamoyl)-4-(3-methoxyanilino)quinoline-3-carboxamide
CFAMM00145596 CHEMBL569791 Bioactive 6-[3-(dimethylcarbamoyl)phenyl]sulfonyl-4-(3-methoxyanilino)quinoline-3-carboxamide
CFAMM00145568 DCL000375 Clinical Trial Drug GSK256066

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

Last update by



60454 visits since 2014 .........


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links


Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543