CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFCD254
Family Name Motilin receptor Ligand GSK962040 Family
No. of Seeds 30 No. of Other Members 457
Family Centroid CFAMM00146181 Functional Category Clinical Trial Drug with Natural Product
Superfamily Motilin receptor Ligand GSK962040 Superfamily
Class Class 252

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Mu-type opioid receptor ligand opiate Remifentanil Family 10 24
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Cholesterol side-chain cleavage enzyme, mitochondrial and Arom... 9 26
Benzodiazepine receptor ligand benzodiazepine derivative Fluni... 2 22
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
DNA Binder Procarbazine Family 8 358
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Histamine H1 receptor Ligand Antazoline Family 5 57
Serum albumin Inhibitor Ebselen Family 3 62
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Androgen receptor Ligand Enzalutamide Family 1 4
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Nitric oxide synthase, brain Inhibitor NXN-188 Family 1 7
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Poly [ADP-ribose] polymerase 1 Inhibitor BSI-201 Family 3 16
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
Substance-P receptor Ligand Vestipitant Family 14 137
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Dual specificity mitogen-activated protein kinase kinase Inhib... 8 4
K-604 family 4 71
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Bavisant family 9 65
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Delta-type opioid receptor Ligand Sb 227122 Family 7 5
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 19 186
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Vasopressin-neurophysin 2-copeptin Inhibitor Niravoline Family 7 45
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Fumarate reductase flavoprotein subunit Inhibitor 2-heptyl-4-h... 3 16
Proto-oncogene tyrosine-protein kinase Src Inhibitor ISO24 Family 3 9
Urokinase-type plasminogen activator Inhibitor 6-(n-phenylcarb... 2 11
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 5 65
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 9 19
Epidermal growth factor receptor Ligand 5,6-bis-p-tolylamino-i... 2 2
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
Potassium voltage-gated channel subfamily A member 5 Ligand N-... 8 32
Integrin beta-3 Inhibitor L-767679 Family 3 6
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Androgen receptor Ligand LG-121071 Family 8 32
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Integrin beta-3 Inhibitor L-750034 Family 7 38
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histone Deacetylase 8 Inhibitor 6-(2-mercaptoacetamido)-n-phen... 4 8
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Poly [ADP-ribose] polymerase 1 Inhibitor 8-amino-6h,11h-indeno... 3 9
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Transient receptor potential cation channel subfamily V member... 6 33
Poly [ADP-ribose] polymerase 1 Inhibitor 3-morpholin-4-ylmethy... 1 2
Cholecystokinin receptor type A Ligand L-708474 Family 14 82
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Androgen receptor Ligand YM-175735 Family 30 129
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 13
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Aurora kinase B Inhibitor Hesperadin Family 1 1
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Cannabinoid receptor 1 Ligand 1-[bis(4-iodophenyl)methyl]-3-(4... 4 13
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Transient receptor potential cation channel subfamily V member... 1 5
Progesterone receptor Ligand 3-(3,3-dimethyl-2-oxoindolin-5-yl... 2 10
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor Benz... 3 12
cAMP-specific 3',5'-cyclic phosphodiesterase 4B Inhibitor 3-(2... 2 2
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 2A Ligand Cinanserin Family 3 27
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Telomerase reverse transcriptase Inhibitor 2,7-bis[2-(piperidi... 6 8
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmaleimid... 2 11
Sphingosine kinase 2 Inhibitor (r)-2-amino-4-hydroxy-n-(4-octy... 3 9
Neutrophil elastase Inhibitor 3-butyl-3-ethyl-1-phenylazetidin... 6 5
Metabotropic glutamate receptor 5 Ligand N-(3-acetamidophenyl)... 4 20
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
MO15-related protein kinase Pfmrk Inhibitor 2-chloro-n-(o-toly... 6 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 9 7
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
Acetylcholinesterase Inhibitor (3-hydroxy-2-methyl-phenyl)-tri... 4 25
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 9h-bet... 1 1
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Tyrosinase Inhibitor 1-hydroxy-3-(4-(trifluoromethyl)phenyl)ur... 2 3
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Leukotriene A-4 hydrolase Inhibitor SA-6541 Family 4 32
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(3-cyanophe... 7 5
DNA topoisomerase Inhibitor 6-(naphthalen-2-ylamino)-1h-pyrimi... 2 1
Myeloperoxidase Inhibitor 4-aminobenzoic Acid Hydrazide Family 1 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 3 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 2 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 6 3
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 5 5
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZFJZ family 1 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 4 8
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 15 24
B2 bradykinin receptor ligand AGN-PC-074WA4 family 2 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 1
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-2-anil... 1 2
Progesterone receptor and Androgen receptor ligand AGN-PC-080P... 4 27
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 6
Disintegrin and metalloproteinase domain-containing protein 17... 1 2
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 3 0
Cathepsin K and Cathepsin B inhibitor AGN-PC-01Z23J family 2 0
E3 ubiquitin-protein ligase Mdm2 inhibitor (2'R,3R,3'S,5'S)-6-... 17 51
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
Melanocortin receptor 4 ligand tert-butyl 4-[(3S)-4-[4-[2-[1-[... 2 6
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Lethal factor inhibitor (2R)-6-[(4-chlorophenyl)methylamino]-2... 3 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
Neuropeptide Y receptor type 2 ligand N-[3-chloro-4-[2-(cyclop... 1 2
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-5-amino-2-c... 3 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 10
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
5-hydroxytryptamine receptor 2A ligand AGN-PC-075LXD family 4 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 5
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
Acetylcholinesterase inhibitor 2-[2-(1-benzylpiperidin-4-yl)et... 2 9
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 6 5
Thyroid hormone receptor beta and DNA-(apurinic or apyrimidini... 1 0
Sigma non-opioid intracellular receptor 1 ligand 2-(2-nitrophe... 2 5
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Calcitonin gene-related peptide type 1 receptor and Dual speci... 8 4
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Cellular tumor antigen p53 inhibitor CHEMBL1554992 family 1 0
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 1
D(2) dopamine receptor and D(3) dopamine receptor ligand 1,1-d... 2 7
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
Equilibrative nucleoside transporter 1 inhibitor Draflazine fa... 1 8
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 8 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Amyloid beta A4 protein inhibitor AGN-PC-08WTQK family 1 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
Melanin-concentrating hormone receptor 1 ligand 1-[2-[4-(3-cya... 3 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Ribosyldihydronicotinamide dehydrogenase [quinone] and Melaton... 1 3
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 3
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 5 37
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 0
Ectonucleotide pyrophosphatase/phosphodiesterase family member... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Kappa-type opioid receptor ligand N-methyl-N-[(1S)-2-pyrrolidi... 3 17
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Transient receptor potential cation channel subfamily V member... 9 38
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Transient receptor potential cation channel subfamily V member... 1 1
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-cyc... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 2
D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-1... 8 0
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Bifunctional epoxide hydrolase 2 inhibitor 1-(3-acetylphenyl)-... 1 3
Kappa-type opioid receptor ligand (2R)-6-amino-2-[[(2R)-2-[[(2... 2 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 4-[[2... 8 2
Substance-P receptor and Potassium voltage-gated channel subfa... 5 0
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 17
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Melanocortin receptor 4 ligand SureCN6183720 family 2 5
Melanin-concentrating hormone receptor 1 ligand SureCN13655018... 6 23
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 3 0
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-0762XZ ... 3 1
5-hydroxytryptamine receptor 7 ligand 1-[2-(4-nitrophenyl)phen... 1 0
Growth hormone secretagogue receptor type 1 ligand N-[4,6-dich... 2 0
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-(piperidin-1... 10 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-(2-... 1 0
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor SureCN3652462 family 5 2
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 2
Plasminogen and Trypsin-1 inhibitor CHEMBL2315239 family 13 1
Mitogen-activated protein kinase 14 inhibitor 3-(3-benzamido-4... 2 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
Phospholipase D1 and Phospholipase D2 inhibitor 4-bromo-N-[(2S... 1 2
Translocator protein inhibitor CHEMBL2332254 family 6 1
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Transient receptor potential M8 protein ligand 2-(4-bromopheny... 1 0
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Receptor activity-modifying protein 1 and Calcitonin gene-rela... 2 4
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
Histamine H3 receptor ligand AGN-PC-0CW63F family 1 1
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 3
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Histamine receptor H3 ligand N-[2-methyl-4-[(3S)-3-[(2S)-2-met... 10 7
Histamine receptor H3 ligand N-[4-[3-(2-methylpyrrolidin-1-yl)... 2 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 3
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 7 0
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 7 ligand 7-chloro-3-[4-[4-(4-chlo... 2 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
5-hydroxytryptamine receptor 7 ligand 2-[4-[4-(2-oxo-1,3,4,5-t... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Chitin synthase 1 inhibitor AC1O53V7 family 9 0
Glutamate receptor ionotropic, NMDA 1 ligand CHEMBL40730 family 4 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 14 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
Substance-P receptor ligand N-[[3,5-bis(trifluoromethyl)phenyl... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
Substance-P receptor and Potassium voltage-gated channel subfa... 5 1
C-C chemokine receptor type 3 ligand AGN-PC-073RIP family 2 4
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[5-... 3 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor SureCN75047... 4 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Caspase-8 and Caspase-3 inhibitor (3S)-3-[[(2S)-4-methyl-2-[[2... 3 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 5
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 0
Protease and Replicase polyprotein 1a inhibitor AC1LALLS family 1 0
C-C chemokine receptor type 3 ligand AGN-PC-075BAT family 1 0
Dipeptidyl peptidase 4 inhibitor 4-[[(3S,5S)-5-[(2S)-2-cyanopy... 4 12
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Progesterone receptor ligand CHEMBL403139 family 2 0
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Somatostatin receptor type 1 ligand AGN-PC-078XL6 family 9 9
Nociceptin receptor and Mu-type opioid receptor ligand spiropi... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Transient receptor potential cation channel subfamily V member... 1 1
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Dipeptidyl peptidase 4 inhibitor (2S,4S)-1-[2-[[1-[4-cyano-2-(... 2 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 1 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 4 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 5
Cathepsin K and Cathepsin B inhibitor AGN-PC-076LFZ family 1 0
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor 3-[(3S)... 1 0
Collagenase 3 and Interstitial collagenase inhibitor (2R,3S)-N... 1 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS0Z family 1 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZK family 3 0
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 3 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(1-hydroxy-3... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
C-C chemokine receptor type 5 ligand AC1MHP8Y family 1 0
Kappa-type opioid receptor ligand 2-[2-[bis(methylsulfonyl)ami... 2 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Retinal dehydrogenase 1 and Nuclear receptor ROR-gamma ligand ... 3 13
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 3
Tyrosine-protein kinase ITK/TSK and Mast/stem cell growth fact... 1 0
Glucose-dependent insulinotropic receptor ligand AGN-PC-04UO8L... 2 2
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 7 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 4-[[2... 2 0
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 2 2
Amyloid beta A4 protein inhibitor (2S,3R)-3-(2-methylpropyl)-N... 1 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide de... 2 4
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(1-cyanocyclop... 4 2
Transient receptor potential M8 protein ligand 1-[(2S)-2-(2-ch... 4 2
Proteasome subunit beta type-5 and Proteasome subunit beta typ... 1 0
E3 ubiquitin-protein ligase XIAP and Cytochrome P450 3A4 inhib... 2 0
Interstitial collagenase and Matrix metalloproteinase-9 inhibi... 2 2
Isoprenyl transferase inhibitor (2S)-N-(4-cyclohexylphenyl)-4-... 3 7
Sterol O-acyltransferase 1 inhibitor SureCN7565101 family 2 10
Substance-P receptor ligand AGN-PC-073MZ3 family 2 0
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN13328411 ... 4 2
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 7 2
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Aldose reductase inhibitor (4R)-6-fluoro-3-methylspiro[1H-quin... 4 16
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
Histone deacetylase 1 inhibitor 2-[4-[(2-aminophenyl)carbamoyl... 1 1
Progesterone receptor ligand AGN-PC-048NI9 family 1 5
Disintegrin and metalloproteinase domain-containing protein 10... 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor N-[2,6-di(propa... 1 2
Transient receptor potential cation channel subfamily A member... 1 0
Voltage-dependent L-type calcium channel subunit alpha-1S liga... 1 0
Proteinase-activated receptor 1 ligand 2-bromo-N-[3-(butanoyla... 4 0
Metabotropic glutamate receptor 2 ligand 4-[4-(methylamino)phe... 1 4
Polymerase acidic protein inhibitor (Z)-4-hydroxy-2-oxo-4-(4-p... 1 0
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 1 0
Lysophosphatidic acid receptor 3 and Microtubule-associated pr... 1 1
Substance-P receptor ligand AGN-PC-01XQZB family 1 0
Sterol O-acyltransferase 1 inhibitor SureCN9848375 family 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 2 0
Substance-P receptor ligand (2S)-2-N-[2-[(3,5-dimethylphenyl)m... 1 1
1,3,3,5-tetramethylspiro[indole-2,6'-piperidine]-2'-one NP 1,3... 2 0
ylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indo... 20 0
NP (1r,5r)-n-((s)-1-((3-chlorophenyl)amino)-1-oxo-3-phenylprop... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00146225 CHEMBL2164669 Bioactive (1R,2R)-N-[cyano(phenyl)methyl]-2-[4-(4-fluorophenyl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
CFAMM00146345 CHEMBL243338 Bioactive SureCN5511357
CFAMM00146393 CHEMBL194914 Bioactive AGN-PC-075WQQ
CFAMM00146103 CHEMBL123227 Bioactive AGN-PC-00GNMU
CFAMM00146425 CHEMBL415887 Bioactive AGN-PC-073NZZ
CFAMM00146110 CHEMBL2029923 Bioactive 2-phenyl-N-[3-[2-(4-phenylpiperazin-1-yl)ethyl]phenyl]acetamide
CFAMM00146496 CHEMBL2111806 Bioactive (2R)-N-(cyanomethyl)-4-methyl-2-[3-[4-(4-methylpiperazin-1-yl)phenyl]phenyl]pentanamide
CFAMM00146396 CHEMBL243578 Bioactive AGN-PC-015H4P
CFAMM00146391 CHEMBL390679 Bioactive AGN-PC-015GZE
CFAMM00146416 CHEMBL1836785 Bioactive 3-[4-[4-(4-fluorophenyl)piperazin-1-yl]butyl]-1,3-dihydroindol-2-one
CFAMM00146335 CHEMBL2364265 Bioactive SureCN1704133
CFAMM00146157 CHEMBL243355 Bioactive SureCN4775407
CFAMM00146472 CHEMBL479755 Bioactive N-(cyanomethyl)-1-[[(1S)-2,2,2-trifluoro-1-[4-(4-piperazin-1-ylphenyl)phenyl]ethyl]amino]cyclohexane-1-carboxamide
CFAMM00146094 CHEMBL243955 Bioactive AGN-PC-046P4Z
CFAMM00146435 CHEMBL489094 Bioactive SureCN1704458
CFAMM00146340 CHEMBL260872 Bioactive 3-ethyl-3-[4-[4-(4-fluorophenyl)piperazin-1-yl]butyl]-1H-indol-2-one
CFAMM00146256 CHEMBL122149 Bioactive N-(cyanomethyl)-4-methyl-2-[3-(4-piperazin-1-ylphenyl)phenyl]pentanamide
CFAMM00146067 CHEMBL243138 Bioactive AGN-PC-015GZF
CFAMM00146413 CHEMBL494312 Bioactive N-[(4-cyanophenyl)methyl]-6-[4-(2-propan-2-ylphenyl)piperazin-1-yl]hexanamide
CFAMM00146181 DCL000398 Clinical Trial Drug GSK962040
CFAMM00146146 DNC008972 Investigative Drug N-Benzyl-4-(2-diphenyl)-1-piperazinehexanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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