CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD255
Family Name Histamine H1 receptor and Histamine H3 receptor Ligand GSK1004723 Family
No. of Seeds 13 No. of Other Members 18
Family Centroid CFAMM00146603 Functional Category Clinical Trial Drug
Superfamily Histamine H1 receptor and Histamine H3 receptor Ligand GSK1004723 Superfamily
Class Class 989

Cousin Family NamesSeedsMembers
Irdabisant family 49 53
Histamine H3 receptor Ligand A-349821 Family 49 228
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 7 9
Survival motor neuron protein inhibitor CHEMBL1303282 family 1 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
Histamine H1 receptor and Histamine H3 receptor ligand 4-[(4-m... 3 6
Histamine H3 receptor ligand SureCN1373218 family 2 2
Histamine H3 receptor ligand 2-methyl-4-[4-(3-pyrrolidin-1-ylp... 4 1
Histamine H3 receptor ligand 7-[4-[3-[(2R)-2-methylpyrrolidin-... 5 1
Histamine H3 receptor ligand 3-methyl-1-[4-(3-piperidin-1-ylpr... 6 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D inhibitor (4aS... 10 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00146600 CHEMBL1767167 Bioactive 2-[[(2R)-1-[5-[4-[3-(azepan-1-yl)propoxy]phenyl]pentyl]pyrrolidin-2-yl]methyl]-4-[(4-chlorophenyl)methyl]phthalazin-1-one
CFAMM00146589 CHEMBL1765111 Bioactive 2-[1-[2-[4-[3-(azepan-1-yl)propoxy]phenyl]ethyl]azepan-4-yl]-4-[(4-chlorophenyl)methyl]phthalazin-1-one
CFAMM00146599 CHEMBL1767166 Bioactive 2-[[(2R)-1-[4-[4-[3-(azepan-1-yl)propoxy]phenyl]butyl]pyrrolidin-2-yl]methyl]-4-[(4-hydroxyphenyl)methyl]phthalazin-1-one
CFAMM00146616 CHEMBL1767159 Bioactive 2-[1-[[4-[3-(azepan-1-yl)propoxy]phenyl]methyl]azepan-4-yl]-4-[(4-chlorophenyl)methyl]phthalazin-1-one
CFAMM00146598 CHEMBL1767161 Bioactive 2-[1-[4-[4-[3-(azepan-1-yl)propoxy]phenyl]butyl]azepan-4-yl]-4-[(4-chlorophenyl)methyl]phthalazin-1-one
CFAMM00146595 CHEMBL1767162 Bioactive 2-[2-[4-[4-[3-(azepan-1-yl)propoxy]phenyl]butylamino]ethyl]-4-[(4-chlorophenyl)methyl]phthalazin-1-one
CFAMM00146621 CHEMBL1835770 Bioactive 2-[(4-chlorophenyl)methyl]-4-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]phthalazin-1-one
CFAMM00146597 CHEMBL1767160 Bioactive 2-[1-[3-[4-[3-(azepan-1-yl)propoxy]phenyl]propyl]azepan-4-yl]-4-[(4-chlorophenyl)methyl]phthalazin-1-one
CFAMM00146620 CHEMBL1767139 Bioactive 4-[(4-ethoxyphenyl)methyl]-2-[[(2R)-1-methylpyrrolidin-2-yl]methyl]phthalazin-1-one
CFAMM00146596 CHEMBL1767163 Bioactive 2-[2-[4-[4-[3-(azepan-1-yl)propoxy]phenyl]butyl-methylamino]ethyl]-4-[(4-chlorophenyl)methyl]phthalazin-1-one
CFAMM00146602 CHEMBL1767165 Bioactive 2-[[(2R)-1-[4-[4-[3-(azepan-1-yl)propoxy]phenyl]butyl]pyrrolidin-2-yl]methyl]-4-[(4-methoxyphenyl)methyl]phthalazin-1-one
CFAMM00146601 CHEMBL1767164 Bioactive SureCN986140
CFAMM00146603 DCL000399 Clinical Trial Drug GSK1004723

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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