CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD257
Family Name Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family
No. of Seeds 7 No. of Other Members 148
Family Centroid CFAMM00146920 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Superfamily
Class Class 614

Cousin Family NamesSeedsMembers
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Histamine H1 receptor Ligand Doxepin Family 8 89
Lipoprotein lipase Inhibitor Gemfibrozil Family 1 28
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Tyrosinase Inhibitor Monobenzone Family 6 197
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
Prostacyclin receptor Ligand Treprostinil Family 1 2
Sodium channel Ligand Permethrin Family 1 25
Peroxisome proliferator-activated receptor alpha Ligand Ciprof... 1 5
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Salicin family 5 629
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Translocator protein Inhibitor Dextofisopam Family 3 250
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
TS-071 family 8 36
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Cathepsin S Inhibitor 2-[(2',3',4'-trifluorobiphenyl-2-yl)oxy]... 2 16
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 2 14
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Prostacyclin receptor Ligand AP-227 Family 1 7
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
Prostaglandin D2 receptor 2 Ligand 2-(4-bromo-2-tert-butylphen... 3 4
Prostaglandin D2 receptor 2 Ligand 2-(2-benzoyl-4-bromophenoxy... 4 35
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Prostaglandin D2 receptor 2 Ligand 2-(4-chloro-2-cyclohexylphe... 7 25
Prostaglandin D2 receptor 2 Ligand 2-(4-cyano-2-cyclohexylphen... 6 3
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 5 8
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Aromatase Inhibitor NSC-122427 Family 1 0
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 6-meth... 2 36
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic... 2 66
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 6 6
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 33
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 7
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 4 37
Prostaglandin D2 receptor 2 ligand SureCN1690387 family 1 0
Prostaglandin D2 receptor 2 ligand AGN-PC-0A9UXE family 7 21
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 3
Prostaglandin D2 receptor 2 ligand 2-[4-cyano-2-[2-(2-methyl-5... 1 0
Free fatty acid receptor 1 ligand 3-[4-[[3-[4-(1,1-dioxothian-... 3 0
Vitamin D3 receptor ligand (3E,5E)-6-[3-[[3,4-bis(hydroxymethy... 2 4
Peroxisome proliferator-activated receptor delta ligand SureCN... 1 0
Protein kinase C alpha type inhibitor [2-(hydroxymethyl)-5-oxo... 2 4
Peroxisome proliferator-activated receptor delta ligand SureCN... 14 16
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 7
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R)... 1 4
Thyroid hormone receptor beta ligand 2-[3,5-dibromo-4-(4-hydro... 1 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 7
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 2 7
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 0
Prostaglandin D2 receptor 2 ligand 2-[2-[2-(2-chlorophenyl)eth... 1 0
Trace amine-associated receptor 1 ligand 4-[4-(2-AMINO-ETHYL)-... 1 0
Neutrophil elastase and Prothrombin inhibitor CHEMBL265335 family 2 4
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 19
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
NS5B protein inhibitor (Z)-4-[2-(3-cyanopropoxy)phenyl]-4-hydr... 2 0
D-amino-acid oxidase inhibitor 5-hydroxy-2-(naphthalen-1-yloxy... 2 0
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 2 4
Benzyloxycarbonyls Metabolite 4-Methoxybenzyl formate Family 1 7
Putative NP ZINC04043753 Family 8 6
NP 4-(chloromethyl)-6-methoxy-2h-chromen-2-one Family 4 2
Putative NP ZINC04029250 Family 6 2
dimethylchromen-2-one NP 4-(chloromethyl)-6,7-dimethyl-2h-chro... 5 2
NP Chemdiv1 023678 Family 4 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00146864 CHEMBL1778631 Bioactive AGN-PC-0A9UXC
CFAMM00146795 CHEMBL419016 Bioactive SureCN12584183
CFAMM00146920 DCL000402 Clinical Trial Drug GSK1034702
CFAMM00146785 DNC008001 Investigative Drug 2-(2-cyclohexyl-4-fluorophenoxy)acetic acid
CFAMM00146783 DNC007998 Investigative Drug 2-(2-cyclohexyl-4-methoxyphenoxy)acetic acid
CFAMM00146782 DNC007999 Investigative Drug 2-(2-cyclohexyl-4-methylphenoxy)acetic acid
CFAMM00146786 DNC008003 Investigative Drug 2-(2-cyclohexylphenoxy)acetic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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