CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD269
Family Name Coagulation factor X Inhibitor Apixaban Family
No. of Seeds 34 No. of Other Members 52
Family Centroid CFAMM00147331 Functional Category Clinical Trial Drug with Natural Product
Superfamily Coagulation factor X Inhibitor Apixaban Superfamily
Class Class 999

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
DCC-2036 family 2 5
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Coagulation factor X and Prothrombin Inhibitor BMS-740808 Family 64 8
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Cannabinoid receptor 1 and 5-hydroxytryptamine receptor 1A lig... 2 12
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Coagulation factor X and Prothrombin inhibitor 2-(3-amino-1,2-... 5 3
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Coagulation factor X inhibitor AGN-PC-00FGDC family 11 5
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cannabinoid receptor 1 ligand NIDA-41020 family 7 5
Sodium channel protein type 9 subunit alpha ligand AGN-PC-09QK... 1 19
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Coagulation factor X and Prothrombin inhibitor 6-[4-[2-[[(3R)-... 15 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
5-hydroxytryptamine receptor 3A ligand 1-[4-[[7-(diethylamino)... 2 4
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Coagulation factor X inhibitor 1-(4-methoxyphenyl)-7-oxo-6-[4-... 5 0
Coagulation factor X and Prothrombin inhibitor 1-(4-methoxyphe... 8 0
Coagulation factor X inhibitor AGN-PC-03K47Q family 3 0
Coagulation factor X inhibitor AGN-PC-046QD2 family 6 0
5-hydroxytryptamine receptor 3A ligand 5-hydroxy-1-methyl-N-[(... 4 2
Coagulation factor X inhibitor SureCN6785555 family 7 0
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Coagulation factor X and Prothrombin inhibitor 6-[4-[2-[[(3R)-... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 7-met... 2 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Vasopressin V2 receptor ligand SureCN4400636 family 1 0
Coagulation factor X inhibitor 2-(4-methoxyphenyl)-N-[5-(2-sul... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Coagulation factor X and Prothrombin inhibitor 6-[4-[2-[[(3R)-... 7 0
Coagulation factor X inhibitor AGN-PC-046RMQ family 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 2 3
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Coagulation factor X inhibitor SureCN5641901 family 5 0
Coagulation factor X inhibitor AGN-PC-077MYE family 16 0
Coagulation factor X inhibitor SureCN5644036 family 30 0
Coagulation factor X inhibitor AGN-PC-077MVW family 5 0
Coagulation factor X inhibitor SureCN5644554 family 2 0
Apoptosis regulator Bcl-2 and Bcl2-associated agonist of cell ... 1 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Histone-arginine methyltransferase CARM1 inhibitor SureCN14565... 2 1
Histone-arginine methyltransferase CARM1 inhibitor pyrazole sc... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00147337 CHEMBL459286 Bioactive AGN-PC-077MVU
CFAMM00147354 CHEMBL464756 Bioactive AGN-PC-077MWS
CFAMM00147329 CHEMBL235694 Bioactive AGN-PC-046L9W
CFAMM00147273 CHEMBL460385 Bioactive SureCN5642787
CFAMM00147360 CHEMBL392460 Bioactive AGN-PC-0146OI
CFAMM00147319 CHEMBL397049 Bioactive AGN-PC-046RMK
CFAMM00147280 CHEMBL515847 Bioactive AGN-PC-077MZW
CFAMM00147272 CHEMBL512288 Bioactive SureCN5642224
CFAMM00147335 CHEMBL247561 Bioactive 6-[1-[2-[[(2S)-2-hydroxypyrrolidin-1-yl]methyl]phenyl]piperidin-4-yl]-1-(4-methoxyphenyl)-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide
CFAMM00147279 CHEMBL392526 Bioactive SureCN2003955
CFAMM00147366 CHEMBL247192 Bioactive AGN-PC-046RMJ
CFAMM00147295 CHEMBL464555 Bioactive AGN-PC-077N6V
CFAMM00147308 CHEMBL443578 Bioactive AGN-PC-046M1K
CFAMM00147358 CHEMBL247756 Bioactive AGN-PC-046RMM
CFAMM00147285 CHEMBL237226 Bioactive SureCN5438232
CFAMM00147301 CHEMBL465499 Bioactive AGN-PC-077MWU
CFAMM00147315 CHEMBL235905 Bioactive AGN-PC-046LMH
CFAMM00147365 CHEMBL247191 Bioactive AGN-PC-046RMI
CFAMM00147307 CHEMBL397298 Bioactive AGN-PC-046RMN
CFAMM00147326 CHEMBL468792 Bioactive AGN-PC-077MXO
CFAMM00147284 CHEMBL237228 Bioactive AGN-PC-046M1J
CFAMM00147300 CHEMBL510030 Bioactive AGN-PC-077MZU
CFAMM00147314 CHEMBL235907 Bioactive SureCN2001907
CFAMM00147333 CHEMBL461454 Bioactive AGN-PC-077MTO
CFAMM00147277 CHEMBL518473 Bioactive AGN-PC-077MTM
CFAMM00147299 CHEMBL396640 Bioactive AGN-PC-03NX7D
CFAMM00147370 CHEMBL451053 Bioactive AGN-PC-077MYH
CFAMM00147313 CHEMBL235906 Bioactive AGN-PC-046LD1
CFAMM00147332 CHEMBL391484 Bioactive SureCN6785643
CFAMM00147349 CHEMBL456676 Bioactive SureCN5646827
CFAMM00147276 CHEMBL235710 Bioactive AGN-PC-046LFW
CFAMM00147363 CHEMBL279187 Bioactive SureCN6781669
CFAMM00147298 CHEMBL246948 Bioactive AGN-PC-046RMO
CFAMM00147331 DCL000438 Clinical Trial Drug Apixaban

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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