CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD271
Family Name Calcium-activated potassium channel subunit alpha-1 Ligand AVE0118 Family
No. of Seeds 3 No. of Other Members 284
Family Centroid CFAMM00147717 Functional Category Clinical Trial Drug with Natural Product
Superfamily Calcium-activated potassium channel subunit alpha-1 Ligand AVE0118 Superfamily
Class Class 656

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
HIV protease Inhibitor Indinavir Family 36 211
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Multidrug resistance-associated protein 1 Inhibitor Biricodar ... 6 40
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Histone deacetylase 1 Inhibitor MS-275 Family 4 41
Cathepsin K Inhibitor Relacatib Family 26 32
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Mast/stem cell growth factor receptor Kit and Vascular endothe... 1 4
Histamine H3 receptor Ligand GSK239512 Family 2 65
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
Sodium-dependent noradrenaline transporter Inhibitor Neri Iv F... 6 58
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Smoothened homolog Inhibitor LDE225 Family 3 76
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Chymase Inhibitor NK3201 Family 1 0
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Oxytocin receptor and Vasopressin V1a receptor Ligand L-372662... 31 23
Renin Inhibitor CP-305202 Family 9 30
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-[3... 1 2
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-... 2 0
C-C chemokine receptor type 5 ligand (2,4-dimethyl-1-oxidopyri... 5 4
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Gonadotropin-releasing hormone receptor ligand 1-[(2,6-difluor... 6 31
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 5 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
cAMP-dependent protein kinase type II-alpha regulatory subunit... 2 4
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 1 0
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 0
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(2-methoxy-3-methylpy... 2 3
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Cathepsin S and Cathepsin K inhibitor AGN-PC-09M7MI family 2 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor [3-[[... 3 68
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 17
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
B2 bradykinin receptor ligand SureCN6640854 family 7 4
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cytochrome P450 2C19 and Inositol monophosphatase 1 inhibitor ... 1 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Histamine H3 receptor ligand SureCN2784306 family 5 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 3 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prothrombin inhibitor AGN-PC-073H0Z family 9 6
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 14
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Histamine H3 receptor ligand 3-[4-[3-[(2R)-2-methylpyrrolidin-... 1 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Mitogen-activated protein kinase 14 inhibitor N-[4-methyl-3-[[... 2 2
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Retinoic acid receptor RXR-alpha ligand 6-[(3-butoxy-5,5,8,8-t... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 10 15
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 7
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 1 13
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
C-C chemokine receptor type 5 ligand 6-cyano-N-[(3R)-3-[4-[N-[... 3 0
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 3 1
Growth hormone secretagogue receptor type 1 and Potassium volt... 2 0
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Beta-1 adrenergic receptor ligand N-[2-[[(2S)-3-(2-cyanophenox... 2 1
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Cholinesterase and Acetylcholinesterase inhibitor 5-hydroxy-7-... 5 19
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-4-[[(4S)... 34 23
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Histamine H3 receptor ligand 6-[[2-[2-[(2R)-2-methylpyrrolidin... 2 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 14 6
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
G-protein coupled bile acid receptor 1 ligand (4-cyclopropyl-2... 2 1
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... 4 14
Motilin receptor ligand SureCN2768193 family 2 1
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Growth hormone secretagogue receptor type 1 ligand N-[(1R)-2-(... 3 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Rho-associated protein kinase 2 inhibitor 2-hydroxyethyl 3-[2-... 2 0
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... 1 0
Transient receptor potential cation channel subfamily V member... 6 1
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 1 0
Neuropeptide Y receptor type 5 ligand AGN-PC-040NYD family 3 7
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Pol polyprotein inhibitor Palinavir deriv. 13 family 1 0
Cathepsin K and Cathepsin L1 inhibitor AC1NR9VX family 2 2
Renin inhibitor SureCN6043852 family 2 0
Renin inhibitor SureCN6042213 family 2 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Pol polyprotein inhibitor Tertiary Amide deriv. 58 family 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN5... 4 1
Thromboxane-A synthase inhibitor SureCN9045578 family 1 12
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family 2 8
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 0
Mitogen-activated protein kinase 9 and Tyrosine-protein kinase... 2 6
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 1 3
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 1
72 kDa type IV collagenase and Aminopeptidase N inhibitor ly52... 1 0
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 6 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Renin inhibitor SureCN7300793 family 2 5
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
Sodium-dependent serotonin transporter and Neuropeptide Y rece... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 4
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
Collagenase 3 inhibitor SureCN1316041 family 4 3
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Pol polyprotein inhibitor N-benzyl-2,2-difluoro-4-[[(2S)-3-met... 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Diacylglycerol O-acyltransferase 1 inhibitor AGN-PC-07ZCRO family 1 2
Prothrombin inhibitor N-[(2S)-3-(4-aminophenyl)-1-[4-(2-fluoro... 7 4
Platelet-activating factor receptor ligand [(2R,4R)-4-(octadec... 3 2
Leucyl-cystinyl aminopeptidase inhibitor SureCN988709 family 1 14
Lysophosphatidic acid receptor 1 and Lysophosphatidic acid rec... 3 6
Transient receptor potential cation channel subfamily V member... 3 2
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 1 0
Potassium voltage-gated channel subfamily A member 5 ligand AG... 1 0
Sodium channel protein type 9 subunit alpha and Sodium channel... 1 1
Dual specificity mitogen-activated protein kinase kinase 1 inh... 1 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Coagulation factor X and Prothrombin inhibitor 3-[4-carbamimid... 3 0
Reverse transcriptase/RNaseH inhibitor 7CN-6Et-9Me-PBOA-5one f... 4 1
Lysophosphatidic acid receptor 1 and Lysophosphatidic acid rec... 1 0
Coagulation factor X inhibitor 3-Oxybenzamide 15 family 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8798759 f... 1 0
Orexin receptor type 1 and Orexin receptor type 2 ligand SureC... 1 3
Beta-1 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 5
Neutrophil elastase inhibitor SureCN8210283 family 2 2
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 1 0
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 1
Fatty-acid amide hydrolase 1 and Monoglyceride lipase inhibito... 1 3
M-phase inducer phosphatase 2 and Dual specificity protein pho... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Metabotropic glutamate receptor 2 ligand 8-chloro-6-[4-[(6-chl... 9 0
Glutamate receptor ionotropic, NMDA 2B ligand AGN-PC-0A9UZU fa... 3 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9RLJ family 1 0
Collagenase 3 inhibitor 4-[4-[2-[(3S)-3-hydroxy-1-azabicyclo[2... 1 0
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 3 1
Pol polyprotein inhibitor Phenprocoumon IndolEtCONH deriv. family 2 0
Platelet-activating factor receptor ligand AGN-PC-001U4L family 2 0
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 2 0
3-(4-methoxyphenyl)-1-pyrrol-1-ylpropan-1-one NP Agn-pc-08zsfd... 1 1
NP (s,z)-n'-(1-((6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin... 1 1
NP 5-((4-chlorobenzyl)oxy)-2-(6,7-dimethoxy-1,2,3,4-tetrahydro... 3 0
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0
NP N-(2-(3,4-dimethoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinami... 6 1
9-(4-methoxyphenyl)-5-(3-methylbutanoyl)-6-pyridin-3-yl-8,9,10... 8 0
NP N-(2-(2-methoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinamide F... 9 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00147711 DNCL002283 Clinical Trial Drug KX2-391
CFAMM00147717 DCL000445 Clinical Trial Drug AVE0118
CFAMM00147633 DNC002858 Investigative Drug 4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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