CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD273
Family Name Nicotinic acetylcholine receptor Ligand AZD0328 Family
No. of Seeds 11 No. of Other Members 97
Family Centroid CFAMM00147940 Functional Category Clinical Trial Drug with Natural Product
Superfamily Nicotinic acetylcholine receptor Ligand AZD0328 Superfamily
Class Class 1002

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Calcium-activated potassium channel subunit alpha-1 Ligand Qui... 3 46
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Apricoxib family 8 77
PF-02545920 family 16 140
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
Nicotinic acetylcholine receptor Ligand SIB-1663 Family 1 0
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Squalene synthase Inhibitor ER-119884 Family 2 3
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 3 24
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 1 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Histamine H1 receptor and Potassium voltage-gated channel subf... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Translocator protein inhibitor SureCN13502542 family 20 2
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 6 4
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Lysosomal Pro-X carboxypeptidase inhibitor 1-(4-chloropyridin-... 6 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)... 3 5
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
Substance-P receptor and Sodium-dependent serotonin transporte... 11 6
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 7
Sodium-dependent serotonin transporter and Histamine H3 recept... 6 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 8
Renin inhibitor SureCN6043852 family 2 0
Renin inhibitor SureCN6042213 family 2 3
Renin inhibitor SureCN6044003 family 1 1
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Sodium-dependent serotonin transporter inhibitor SureCN5878703... 4 5
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Renin inhibitor SureCN7300793 family 2 5
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 7 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
Nischarin inhibitor SureCN7810370 family 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 6 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 3
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Coagulation factor X inhibitor JTV-803 free base family 4 7
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Glutamate receptor ionotropic, NMDA 2B and Cytochrome P450 2D6... 2 3
Farnesyl pyrophosphate synthase inhibitor [phosphono-[[4-(4-pr... 6 0
Hormone-sensitive lipase inhibitor AGN-PC-046LTD family 3 8
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Reverse transcriptase/RNaseH inhibitor 6Et-7,9-diMe-PBOA-5thio... 1 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Metabotropic glutamate receptor 5 ligand AGN-PC-09SFJI family 1 0
Pol polyprotein inhibitor tert-butyl N-[(2S,3R)-3-hydroxy-4-[[... 1 1
4-methyl-7-(pyridin-3-ylmethylideneamino)chromen-2-one NP (e)-... 1 0
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00147878 CHEMBL195345 Bioactive PSAB-OFP
CFAMM00147945 CHEMBL247062 Bioactive AGN-PC-00QRO5
CFAMM00147883 CHEMBL193329 Bioactive SureCN5488270
CFAMM00147923 CHEMBL163178 Bioactive SureCN7139683
CFAMM00147940 DCL000450 Clinical Trial Drug AZD0328

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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