CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD275
Family Name Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family
No. of Seeds 24 No. of Other Members 11
Family Centroid CFAMM00147985 Functional Category Clinical Trial Drug
Superfamily Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Superfamily
Class Class 851

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Tivozanib family 4 6
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Ibrutinib family 2 27
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Platelet-derived growth factor receptor beta and Macrophage co... 8 0
Platelet-derived growth factor receptor beta and Macrophage co... 7 0
Platelet-derived growth factor receptor beta and Mast/stem cel... 1 0
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Aurora kinase A inhibitor SureCN4289024 family 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 9
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Histone-lysine N-methyltransferase EHMT2 inhibitor N-(1-cyclop... 1 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D inhibitor Sure... 2 6
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00147972 CHEMBL386310 Bioactive SureCN4286999
CFAMM00147965 CHEMBL262434 Bioactive SureCN4293621
CFAMM00147978 CHEMBL214637 Bioactive SureCN3489868
CFAMM00147991 CHEMBL215022 Bioactive SureCN3490173
CFAMM00147971 CHEMBL215203 Bioactive SureCN3488439
CFAMM00147998 CHEMBL214601 Bioactive SureCN4289124
CFAMM00147977 CHEMBL216053 Bioactive SureCN3490339
CFAMM00147964 CHEMBL263067 Bioactive SureCN4289365
CFAMM00147970 CHEMBL217804 Bioactive SureCN4288439
CFAMM00147983 CHEMBL214849 Bioactive SureCN3490520
CFAMM00147976 CHEMBL424899 Bioactive SureCN4291343
CFAMM00147969 CHEMBL386253 Bioactive SureCN4296517
CFAMM00147982 CHEMBL214848 Bioactive SureCN4292481
CFAMM00147975 CHEMBL216769 Bioactive SureCN3488241
CFAMM00147988 CHEMBL215275 Bioactive SureCN4290814
CFAMM00147994 CHEMBL384054 Bioactive SureCN4295330
CFAMM00147981 CHEMBL385049 Bioactive SureCN3491852
CFAMM00147987 CHEMBL215322 Bioactive SureCN3490409
CFAMM00147980 CHEMBL214842 Bioactive SureCN4294137
CFAMM00147973 CHEMBL385597 Bioactive SureCN4290803
CFAMM00147986 CHEMBL214940 Bioactive SureCN4290487
CFAMM00147966 CHEMBL215152 Bioactive 722544-51-6
CFAMM00147979 CHEMBL215495 Bioactive SureCN3490980
CFAMM00147985 DCL000452 Clinical Trial Drug AZD1152

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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