CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD279
Family Name Cannabinoid receptor 1 Ligand AZD2207 Family
No. of Seeds 18 No. of Other Members 48
Family Centroid CFAMM00148043 Functional Category Clinical Trial Drug
Superfamily Cannabinoid receptor 1 Ligand AZD2207 Superfamily
Class Class 1006

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Transient receptor potential cation channel subfamily V member... 16 295
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Substance-P receptor Ligand TAK-637 Family 18 63
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
GDC-0349 family 44 77
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Reverse transcriptase Inhibitor PT-109 Family 6 7
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Cannabinoid receptor 1 Ligand 1-(4-chlorophenyl)-2-(2,4-dichlo... 18 41
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
Prothrombin inhibitor SureCN5855286 family 15 8
Prothrombin inhibitor SureCN7371121 family 13 3
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 2
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Adenosine receptor A3 ligand AGN-PC-07N4XX family 6 10
ALK tyrosine kinase receptor ligand SureCN1600195 family 1 1
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor AG... 5 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Prothrombin inhibitor AGN-PC-09QLAK family 10 2
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Beta-secretase 1 inhibitor 3-[2-amino-6-(2-methylphenyl)quinol... 5 2
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(2-amino-6... 13 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Sodium- and chloride-dependent glycine transporter 1 and Sodiu... 4 8
Prothrombin inhibitor 2-[3-cyano-6-(2,2-difluoro-2-pyridin-2-y... 3 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Prothrombin inhibitor SureCN7111496 family 1 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Transient receptor potential cation channel subfamily V member... 57 4
Transient receptor potential cation channel subfamily V member... 2 0
Transient receptor potential cation channel subfamily V member... 2 4
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 6 3
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
B1 bradykinin receptor ligand N-[4-chloro-2-[[(1R)-1-[4-[3-flu... 5 5
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Beta-secretase 1 inhibitor N-[(2S,3R)-3-amino-4-fluoro-1-pheny... 4 17
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Transient receptor potential cation channel subfamily V member... 22 3
Prothrombin inhibitor 2-[6-chloro-3-[(2,2-difluoro-2-pyridin-2... 4 3
Prothrombin inhibitor SureCN6057665 family 2 0
Prothrombin inhibitor 2-[6-cyano-3-[[2,2-difluoro-2-(3-methylp... 10 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Prothrombin inhibitor N-[(6-amino-2-methylpyridin-3-yl)methyl]... 2 0
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[(2... 3 1
Fibroblast growth factor receptor 1 and Proto-oncogene tyrosin... 2 0
Calpain-1 catalytic subunit inhibitor 2,6-dichloro-N-[(2S)-3,4... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00148061 CHEMBL195366 Bioactive SureCN7111132
CFAMM00148087 CHEMBL373270 Bioactive SureCN7111701
CFAMM00148080 CHEMBL197418 Bioactive AGN-PC-00FIA1
CFAMM00148093 CHEMBL366233 Bioactive 2-[3-chloro-6-(2,2-difluoro-2-pyridin-2-ylethyl)imino-1-hydroxypyridin-2-yl]-N-[(3-fluoropyridin-2-yl)methyl]acetamide
CFAMM00148060 CHEMBL197141 Bioactive SureCN7113205
CFAMM00148079 CHEMBL524804 Bioactive AGN-PC-077JX7
CFAMM00148092 CHEMBL193688 Bioactive N-[(1S)-1-[2-(aminomethyl)-5-chlorophenyl]ethyl]-2-[3-chloro-6-(2,2-difluoro-2-pyridin-2-ylethyl)imino-1-hydroxypyridin-2-yl]acetamide
CFAMM00148105 CHEMBL250651 Bioactive N-[(6-amino-2-methylpyridin-3-yl)methyl]-2-[6-chloro-3-[[2-(5-chloro-1-oxidopyridin-1-ium-2-yl)-2,2-difluoroethyl]amino]-2-fluorophenyl]acetamide
CFAMM00148046 CHEMBL250466 Bioactive N-[(6-amino-2-methylpyridin-3-yl)methyl]-2-[6-chloro-3-[[2-(5-chloropyridin-2-yl)-2,2-difluoroethyl]amino]-2-fluorophenyl]acetamide
CFAMM00148078 CHEMBL372367 Bioactive SureCN7110792
CFAMM00148097 CHEMBL2177397 Bioactive N-[[2-[4-(3-chloropyridin-2-yl)-2-methylpiperazin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00148090 CHEMBL197464 Bioactive N-[[2-[(1R)-1-aminoethyl]-5-chlorophenyl]methyl]-2-[3-chloro-6-(2,2-difluoro-2-pyridin-2-ylethyl)imino-1-hydroxypyridin-2-yl]acetamide
CFAMM00148050 CHEMBL196035 Bioactive SureCN7108074
CFAMM00148069 CHEMBL382542 Bioactive SureCN7108999
CFAMM00148062 CHEMBL2179154 Bioactive N-[[2-[4-(3-chloropyridin-2-yl)piperazin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
CFAMM00148075 CHEMBL195313 Bioactive AGN-PC-075WB8
CFAMM00148107 CHEMBL193502 Bioactive 2-[3-chloro-6-(2,2-difluoro-2-pyridin-2-ylethyl)imino-1-hydroxypyridin-2-yl]-N-[[2-(1,2,4-triazol-1-yl)phenyl]methyl]acetamide
CFAMM00148043 DCL000462 Clinical Trial Drug AZD2207

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21768 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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