CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD28
Family Name Transient receptor potential cation channel subfamily V member 1 Ligand AMG-517 Family
No. of Seeds 42 No. of Other Members 32
Family Centroid CFAMM00129389 Functional Category Clinical Trial Drug
Superfamily Transient receptor potential cation channel subfamily V member 1 Ligand AMG-517 Superfamily
Class Class 834

Cousin Family NamesSeedsMembers
Multiple kinase Inhibitor MGCD265 Family 19 71
Rho-associated protein kinase 2 inhibitor SureCN13457044 family 1 17
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Adenosine receptor A2b and Adenosine receptor A2a ligand AGN-P... 10 36
Adenosine receptor A2a and Adenosine receptor A2b ligand AGN-P... 4 2
Adenosine receptor A1 and Adenosine receptor A2b ligand AGN-PC... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 7
Growth hormone secretagogue receptor type 1 ligand 6-(1,3-benz... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Tyrosine-protein kinase ITK/TSK and Tyrosine-protein kinase Lc... 2 6
Hepatocyte growth factor receptor ligand AGN-PC-077PZW family 1 0
Prelamin-A/C and Ferritin light chain inhibitor F2515-0224 family 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00129450 CHEMBL227316 Bioactive AGN-PC-009W7S
CFAMM00129402 CHEMBL446455 Bioactive N-[4-[2-(pyridin-4-ylmethylamino)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
CFAMM00129415 CHEMBL227210 Bioactive N-[4-[6-(4-phenylpiperazin-1-yl)pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
CFAMM00129429 CHEMBL251565 Bioactive tert-butyl 4-[4-[(2-acetamido-1,3-benzothiazol-4-yl)oxy]-6-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
CFAMM00129457 CHEMBL500380 Bioactive AGN-PC-077M9Z
CFAMM00129436 CHEMBL389259 Bioactive AGN-PC-015BRG
CFAMM00129388 CHEMBL251559 Bioactive AGN-PC-00BSR4
CFAMM00129449 CHEMBL249731 Bioactive AGN-PC-00D3RV
CFAMM00129401 CHEMBL390934 Bioactive N-[4-[6-[4-[(1S)-1-(4-fluorophenyl)ethyl]piperazin-1-yl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
CFAMM00129428 CHEMBL455580 Bioactive (2S)-N-[2-[6-[(2-acetamido-1,3-benzothiazol-4-yl)oxy]pyrimidin-4-yl]-5-(trifluoromethyl)phenyl]-5-methyl-1-(2-methylpropyl)pyrrolidine-2-carboxamide
CFAMM00129455 CHEMBL229431 Bioactive AGN-PC-015BOG
CFAMM00129407 CHEMBL453146 Bioactive (2R)-N-[2-[6-[(2-acetamido-1,3-benzothiazol-4-yl)oxy]pyrimidin-4-yl]-5-(trifluoromethyl)phenyl]-1-(2-methylpropyl)pyrrolidine-2-carboxamide
CFAMM00129435 CHEMBL398968 Bioactive N-[4-[2-[[1-(2-methylpropyl)piperidin-2-yl]methylamino]-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
CFAMM00129387 CHEMBL249984 Bioactive N-[4-[2-(dimethylamino)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
CFAMM00129400 CHEMBL525804 Bioactive AGN-PC-077MCC
CFAMM00129427 CHEMBL227317 Bioactive AGN-PC-0049SR
CFAMM00129441 CHEMBL387512 Bioactive AGN-PC-006OA6
CFAMM00129393 CHEMBL227228 Bioactive 4-Oxopyrimidine, 21
CFAMM00129419 CHEMBL447666 Bioactive (2S)-N-[2-[6-[(2-acetamido-1,3-benzothiazol-4-yl)oxy]pyrimidin-4-yl]-5-(trifluoromethyl)phenyl]-2-methyl-1-(2-methylpropyl)pyrrolidine-2-carboxamide
CFAMM00129434 CHEMBL226572 Bioactive AGN-PC-007EBL
CFAMM00129412 CHEMBL495673 Bioactive AGN-PC-03GVDV
CFAMM00129425 CHEMBL251560 Bioactive N-[4-[2-(1-pyridin-3-ylethylamino)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
CFAMM00129453 CHEMBL227260 Bioactive AGN-PC-015BRJ
CFAMM00129392 CHEMBL525417 Bioactive (2S)-N-[2-[6-[(2-acetamido-1,3-benzothiazol-4-yl)oxy]pyrimidin-4-yl]-5-(trifluoromethyl)phenyl]-5-methylpyrrolidine-2-carboxamide
CFAMM00129385 CHEMBL496135 Bioactive AGN-PC-077M7X
CFAMM00129391 CHEMBL251348 Bioactive AGN-PC-00DTTP
CFAMM00129439 CHEMBL467600 Bioactive AGN-PC-04SS4M
CFAMM00129417 CHEMBL251352 Bioactive N-[4-[2-(pyridin-2-ylmethylamino)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
CFAMM00129431 CHEMBL445237 Bioactive (2S)-N-[2-[6-[(2-acetamido-1,3-benzothiazol-4-yl)oxy]pyrimidin-4-yl]-5-(trifluoromethyl)phenyl]-1-(2-methylpropyl)pyrrolidine-2-carboxamide
CFAMM00129384 CHEMBL249983 Bioactive N-[4-[2-methyl-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
CFAMM00129397 CHEMBL375460 Bioactive AGN-PC-015BOH
CFAMM00129459 CHEMBL398411 Bioactive N-[4-[2-morpholin-4-yl-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
CFAMM00129410 CHEMBL496725 Bioactive (2R)-N-[2-[6-[(2-acetamido-1,3-benzothiazol-4-yl)oxy]pyrimidin-4-yl]-5-(trifluoromethyl)phenyl]pyrrolidine-2-carboxamide
CFAMM00129390 CHEMBL251556 Bioactive AGN-PC-00DOPR
CFAMM00129416 CHEMBL250185 Bioactive N-[4-[2-piperidin-1-yl-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
CFAMM00129444 CHEMBL482411 Bioactive N-[4-[6-[6-(trifluoromethyl)pyridin-3-yl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
CFAMM00129458 CHEMBL398410 Bioactive AGN-PC-04SS0W
CFAMM00129383 CHEMBL248741 Bioactive AGN-PC-00ARQO
CFAMM00129396 CHEMBL400571 Bioactive AGN-PC-014VYN
CFAMM00129437 CHEMBL500379 Bioactive (2S)-N-[2-[6-[(2-acetamido-1,3-benzothiazol-4-yl)oxy]pyrimidin-4-yl]-5-(trifluoromethyl)phenyl]-2-methylpyrrolidine-2-carboxamide
CFAMM00129389 DCL000044 Clinical Trial Drug AMG-517
CFAMM00129386 DNC013314 Investigative Drug AMG-628

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21760 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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