CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD282
Family Name C-C chemokine receptor type 5 Ligand AZD5672 Family
No. of Seeds 25 No. of Other Members 70
Family Centroid CFAMM00148214 Functional Category Clinical Trial Drug
Superfamily C-C chemokine receptor type 5 Ligand AZD5672 Superfamily
Class Class 905

Cousin Family NamesSeedsMembers
Opioid receptor Ligand Methadone Family 3 39
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Cathepsin K Inhibitor Odanacatib Family 33 84
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Muscarinic acetylcholine receptor M2 Ligand SCH-211803 Family 3 6
Cruzipain Inhibitor K-777 Family 3 8
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 0
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Muscarinic acetylcholine receptor M2 ligand [4-[(3R)-3-methyl-... 3 4
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745OU family 6 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 7 0
Sigma non-opioid intracellular receptor 1 ligand ST50280143 fa... 3 54
Substance-P receptor and Substance-K receptor ligand ZD-6021 f... 3 4
Acetylcholinesterase and Butyrylcholinesterase inhibitor N-[2-... 3 7
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
C-C chemokine receptor type 5 ligand methyl N-[1-[(3S)-4-[benz... 3 18
C-C chemokine receptor type 5 ligand benzyl N-[1-[(3S)-4-[benz... 13 3
C-C chemokine receptor type 5 ligand N-[1-[(3R)-4-[benzenesulf... 3 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 2 5
C-C chemokine receptor type 5 ligand AGN-PC-075XOD family 2 0
C-C chemokine receptor type 5 ligand AGN-PC-075XPW family 3 3
Neutrophil elastase inhibitor SureCN6619034 family 1 8
Cannabinoid receptor 2 ligand AGN-PC-04VLWN family 9 4
Cannabinoid receptor 2 ligand N-cyclohexyl-4-propan-2-yl-3-pyr... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 5
C-C chemokine receptor type 5 ligand N-[1-[(3R)-4-[benzenesulf... 3 1
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[2-(3-methy... 1 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[ethyl-[2-(4... 1 1
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
Cannabinoid receptor 1 ligand ZINC01044238 family 2 0
Cannabinoid receptor 1 ligand SureCN13668467 family 6 3
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00148199 CHEMBL1951908 Bioactive N-ethyl-2-(4-methylsulfonylphenyl)-N-[1-[(3R)-3-phenyl-3-[1-(trifluoromethylsulfonyl)piperidin-4-yl]propyl]piperidin-4-yl]acetamide
CFAMM00148213 CHEMBL179993 Bioactive AGN-PC-075E1H
CFAMM00148219 CHEMBL1951912 Bioactive N-ethyl-N-[1-[(3R)-3-(3-fluorophenyl)-3-(1-methylsulfonylpiperidin-4-yl)propyl]piperidin-4-yl]-2-(4-methylsulfonylphenyl)acetamide
CFAMM00148134 CHEMBL212689 Bioactive UNII-61XQN688TW
CFAMM00148163 CHEMBL197641 Bioactive AGN-PC-075XR7
CFAMM00148140 CHEMBL382435 Bioactive N-[1-[(3R)-3-(3-chloro-5-fluorophenyl)-3-(4-methylsulfonylphenyl)propyl]piperidin-4-yl]-N-ethyl-2-(4-methylsulfonylphenyl)acetamide
CFAMM00148191 CHEMBL1949696 Bioactive N-ethyl-2-(4-methylsulfonylphenyl)-N-[1-[3-phenyl-3-[1-(2,2,2-trifluoroethylsulfonyl)piperidin-4-yl]propyl]piperidin-4-yl]acetamide
CFAMM00148203 CHEMBL1951904 Bioactive N-[1-[3-(1-benzylpiperidin-4-yl)-3-phenylpropyl]piperidin-4-yl]-N-ethyl-2-(4-methylsulfonylphenyl)acetamide
CFAMM00148217 CHEMBL1951918 Bioactive N-ethyl-2-(4-methylsulfonylphenyl)-N-[1-[(3R)-3-(1-methylsulfonylpiperidin-4-yl)-3-[3-(trifluoromethyl)phenyl]propyl]piperidin-4-yl]acetamide
CFAMM00148168 CHEMBL1951898 Bioactive N-ethyl-2-(4-methylsulfonylphenyl)-N-[1-[(3S)-3-phenyl-3-[4-(trifluoromethylsulfonyl)piperazin-1-yl]propyl]piperidin-4-yl]acetamide
CFAMM00148196 CHEMBL198150 Bioactive AGN-PC-00D4ER
CFAMM00148224 CHEMBL1951917 Bioactive N-[1-[(3R)-3-(3-chlorophenyl)-3-(1-methylsulfonylpiperidin-4-yl)propyl]piperidin-4-yl]-N-ethyl-2-(4-methylsulfonylphenyl)acetamide
CFAMM00148154 CHEMBL211866 Bioactive SureCN6339869
CFAMM00148167 CHEMBL1951899 Bioactive N-ethyl-2-(4-methylsulfonylphenyl)-N-[1-[(3S)-3-phenyl-3-[4-(2,2,2-trifluoroethylsulfonyl)piperazin-1-yl]propyl]piperidin-4-yl]acetamide
CFAMM00148195 CHEMBL2178577 Bioactive N-[1-[(3R)-3-(3,5-difluorophenyl)-3-(4-methylsulfonylcyclohexyl)propyl]piperidin-4-yl]-N-ethyl-2-(4-methylsulfonylphenyl)acetamide
CFAMM00148223 CHEMBL1951916 Bioactive N-[1-[(3R)-3-(3,5-dimethylphenyl)-3-(1-methylsulfonylpiperidin-4-yl)propyl]piperidin-4-yl]-N-ethyl-2-(4-methylsulfonylphenyl)acetamide
CFAMM00148201 CHEMBL1951906 Bioactive N-ethyl-2-(4-methylsulfonylphenyl)-N-[1-[(3R)-3-(1-methylsulfonylpiperidin-4-yl)-3-phenylpropyl]piperidin-4-yl]acetamide
CFAMM00148153 CHEMBL2010851 Bioactive N-[(3S,4R)-3-fluoro-1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]-N-methyl-2-(4-methylsulfonylphenyl)acetamide
CFAMM00148166 CHEMBL198758 Bioactive AGN-PC-075XRI
CFAMM00148179 CHEMBL1952100 Bioactive N-[1-[(3R)-3-(3,5-dichlorophenyl)-3-(1-methylsulfonylpiperidin-4-yl)propyl]piperidin-4-yl]-N-ethyl-2-(4-methylsulfonylphenyl)acetamide
CFAMM00148208 CHEMBL212731 Bioactive N-ethyl-N-[1-[(3R)-3-(3-fluorophenyl)-3-(4-methylsulfonylphenyl)propyl]piperidin-4-yl]-2-(4-methylsulfonylphenyl)acetamide
CFAMM00148222 CHEMBL1951915 Bioactive N-[1-[(3R)-3-(3-chloro-5-fluorophenyl)-3-(1-methylsulfonylpiperidin-4-yl)propyl]piperidin-4-yl]-N-ethyl-2-(4-methylsulfonylphenyl)acetamide
CFAMM00148200 CHEMBL1951907 Bioactive N-ethyl-N-[1-[3-(1-ethylsulfonylpiperidin-4-yl)-3-phenylpropyl]piperidin-4-yl]-2-(4-methylsulfonylphenyl)acetamide
CFAMM00148220 CHEMBL1951913 Bioactive N-ethyl-N-[1-[(3R)-3-(3-methylphenyl)-3-(1-methylsulfonylpiperidin-4-yl)propyl]piperidin-4-yl]-2-(4-methylsulfonylphenyl)acetamide
CFAMM00148214 DCL000470 Clinical Trial Drug AZD5672

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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