CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD288
Family Name Serine/threonine-protein kinase Chk1 Inhibitor AZD7762 Family
No. of Seeds 26 No. of Other Members 90
Family Centroid CFAMM00148389 Functional Category Clinical Trial Drug
Superfamily Serine/threonine-protein kinase Chk1 Inhibitor AZD7762 Superfamily
Class Class 1011

Cousin Family NamesSeedsMembers
Atrial natriuretic peptide receptor 1 Ligand Ataciguat Family 7 45
Adenosine receptor A2a Ligand T-62 Family 1 4
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 2 0
Gonadotropin-releasing hormone receptor Ligand TAK-013 Family 19 10
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 2 5
Monocarboxylate transporter 1 inhibitor 3-methyl-1-(2-methylpr... 9 7
Histone deacetylase 1 and Potassium voltage-gated channel subf... 4 36
Serine/threonine-protein kinase Chk1 inhibitor AGN-PC-09M88E f... 1 7
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL13009... 1 6
Coagulation factor X inhibitor benzothiophene compound, 4 family 9 10
Thyroid hormone receptor beta and Cellular tumor antigen p53 l... 1 4
Prelamin-A/C inhibitor CHEMBL1547148 family 1 8
Thyroid hormone receptor beta ligand CHEMBL1554195 family 1 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 0
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand 2-... 6 9
Flap endonuclease 1 and DNA repair protein complementing XP-G ... 3 2
Flap endonuclease 1 and DNA repair protein complementing XP-G ... 4 0
Melanin-concentrating hormone receptor 1 ligand (3S)-3-[[5-[4-... 1 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 5 14
Mitogen-activated protein kinase 14 inhibitor 1-[5-tert-butyl-... 2 14
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 6 6
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 4 7
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-chl... 1 7
Transient receptor potential M8 protein ligand 2-(1-benzothiop... 1 0
Histone deacetylase 1 inhibitor SureCN3642893 family 10 23
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 10 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 3
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 1 0
Adenosine receptor A1 ligand SureCN1497817 family 9 4
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 7 11
Serine/threonine-protein kinase Chk1 inhibitor SureCN1564756 f... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 1 11
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00148280 CHEMBL519248 Bioactive SureCN1563480
CFAMM00148297 CHEMBL527881 Bioactive SureCN1564283
CFAMM00148391 CHEMBL2070702 Bioactive 3-(carbamoylamino)-5-(4-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide;hydrochloride
CFAMM00148408 CHEMBL487273 Bioactive SureCN1562811
CFAMM00148319 CHEMBL2041933 Bioactive AZD7762
CFAMM00148367 CHEMBL2070716 Bioactive 3-(carbamoylamino)-5-(3-cyanophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide;hydrochloride
CFAMM00148272 CHEMBL471096 Bioactive N-[(3R)-azepan-3-yl]-2-(carbamoylamino)-5-phenylthiophene-3-carboxamide
CFAMM00148390 CHEMBL2070701 Bioactive 2-(carbamoylamino)-5-(4-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-3-carboxamide;hydrochloride
CFAMM00148307 CHEMBL459631 Bioactive SureCN1563495
CFAMM00148314 CHEMBL470289 Bioactive SureCN1564142
CFAMM00148268 CHEMBL487622 Bioactive SureCN1564152
CFAMM00148284 CHEMBL2070697 Bioactive 3-(carbamoylamino)-5-phenyl-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide;hydrochloride
CFAMM00148313 CHEMBL470288 Bioactive SureCN1563567
CFAMM00148363 CHEMBL2070713 Bioactive 2-(carbamoylamino)-5-(4-cyanophenyl)-N-[(3S)-piperidin-3-yl]thiophene-3-carboxamide;hydrochloride
CFAMM00148387 CHEMBL2070706 Bioactive 3-(carbamoylamino)-5-(3,5-difluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide;hydrochloride
CFAMM00148282 CHEMBL2070698 Bioactive 2-(carbamoylamino)-5-(2-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-3-carboxamide;hydrochloride
CFAMM00148301 CHEMBL469481 Bioactive SureCN1562808
CFAMM00148396 CHEMBL516784 Bioactive SureCN1563692
CFAMM00148369 CHEMBL2070714 Bioactive 3-(carbamoylamino)-5-(4-cyanophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide;hydrochloride
CFAMM00148386 CHEMBL504542 Bioactive SureCN1564576
CFAMM00148337 CHEMBL488044 Bioactive SureCN1564904
CFAMM00148368 CHEMBL2070715 Bioactive 2-(carbamoylamino)-5-(3-cyanophenyl)-N-[(3S)-piperidin-3-yl]thiophene-3-carboxamide;hydrochloride
CFAMM00148385 CHEMBL2070704 Bioactive 3-(carbamoylamino)-5-(3-chlorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide;hydrochloride
CFAMM00148288 CHEMBL513191 Bioactive SureCN1562899
CFAMM00148356 CHEMBL519913 Bioactive 2-(carbamoylamino)-N-[(3S)-piperidin-3-yl]-5-thiophen-2-ylthiophene-3-carboxamide
CFAMM00148389 DCL000480 Clinical Trial Drug AZD7762

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543