CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name DNA topoisomerase 1 Inhibitor Beta-lapachone Family
No. of Seeds 3 No. of Other Members 66
Family Centroid CFAMM00148555 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily DNA topoisomerase 1 Inhibitor Beta-lapachone Superfamily
Class Class 1012

Cousin Family NamesSeedsMembers
Retinoid X receptor Ligand Bexarotene Family 7 492
Aldehyde oxidase inhibitor para-naphthoquinone Menadione Family 22 503
Dihydroorotate dehydrogenase Inhibitor Dichloroallyl Lawsone F... 1 1
Dihydroorotate dehydrogenase Inhibitor Polyporic Acid Family 4 13
Carbonic anhydrase 2 Inhibitor 4-(hydroxymercury)benzoic Acid ... 7 97
Nicotinate-nucleotide pyrophosphorylase [carboxylating] Inhibi... 2 119
Liver carboxylesterase 1 Inhibitor 1,2-bis(2,5-difluorophenyl)... 12 10
Liver carboxylesterase 1 Inhibitor 2,2-dimethoxy-1,2-diphenyl-... 1 16
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor (5r,... 3 9
Neutrophil elastase Inhibitor 3,4-dichloroisocoumarin Family 1 5
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-methoxy-1,4-naphthoq... 1 3
Fatty-acid amide hydrolase 1 Inhibitor 3-(ethoxycarbonyl)pheny... 2 69
RAC-alpha serine/threonine-protein kinase inhibitor CHEMBL4754... 2 17
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 10
Thyrotropin receptor and Retinal dehydrogenase 1 ligand NINHYD... 1 1
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 18
Aromatase inhibitor [(8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo... 2 10
Benzyloxycarbonyls Metabolite Benzyl acetate Family 5 53
Aromatic Homomonocyclic Compounds Metabolite Dimethylbenzyl ca... 2 11
Putative NP ZINC14410655 Family 6 4
3-methyl-1-oxo-4H-isochromene-3-carboxylate NP Methyl 3-methyl... 4 1
3-(4-hydroxy-6-methyl-2-oxopyran-3-yl)-3H-2-benzofuran-1-one N... 2 2
carboxylate NP ZINC04026424 Family 3 7
(4,5-dioxooxolan-3-ylidene)-phenylmethanolate NP Agn-pc-03fjc2... 1 0
methylbenzoate NP 7-oxocyclohepta-1,3,5-trien-1-yl 3-methylben... 2 1


External ID

Functional Category

Molecule Name

CFAMM00148555 DCL000494 Clinical Trial Drug Beta-Lapachone
CFAMM00148554 DNC008338 Investigative Drug 2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
CFAMM00148528 DNC009074 Investigative Drug 4-ethoxynaphthalene-1,2-dione

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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