CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD297
Family Name Cannabinoid receptor 1 Ligand CP-945598 Family
No. of Seeds 18 No. of Other Members 173
Family Centroid CFAMM00148830 Functional Category Clinical Trial Drug with Natural Product
Superfamily Cannabinoid receptor 1 Binder Superfamily
Class Class 1016

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Cytochrome P450 3A4 Inhibitor Clotrimazole Family 16 145
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Benzodiazepine receptor Ligand Midazolam Family 5 160
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Histamine H1 receptor Ligand Mizolastine Family 14 603
Prothrombin Inhibitor Dabigatran Family 7 182
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Transient receptor potential cation channel subfamily V member... 6 66
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
HCV NS4B protein Inhibitor Clemizole Family 2 43
RAC-gamma serine/threonine-protein kinase Inhibitor GDC-0068 F... 20 29
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
SB989 family 17 91
GDC-0349 family 44 77
JAK Inhibitor Momelotinib Family 33 83
PF-4217903 family 14 65
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... 11 20
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Histamine H3 receptor Ligand SCH79687 Family 11 29
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Aromatase Inhibitor NSC-356781 Family 3 10
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Cannabinoid receptor 1 Ligand 1-(4-chlorophenyl)-2-(2,4-dichlo... 18 41
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor SureCN5856722 family 3 16
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Adenosine receptor A1 ligand SureCN10614388 family 5 1
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YT9... 28 20
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 21
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
Platelet-activating factor receptor ligand SureCN9383514 family 4 1
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Platelet-activating factor receptor ligand 5-methyl-2-[4-(2-me... 1 2
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
Transient receptor potential cation channel subfamily V member... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor AG... 5 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 4 inhibitor Su... 5 13
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Adenosine receptor A2b and Adenosine receptor A2a ligand CP-66... 3 33
Lysosomal Pro-X carboxypeptidase inhibitor 2-amino-N-[(2S)-1-[... 11 16
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 9 31
Cellular tumor antigen p53 inhibitor CHEMBL1318500 family 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Dihydrofolate reductase inhibitor AC1LAKWV family 2 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlo... 11 2
Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... 2 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Bile acid receptor and Potassium voltage-gated channel subfami... 2 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 14
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Lysosomal Pro-X carboxypeptidase inhibitor 1-[(2S)-2-(5,6-dich... 3 10
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 14
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 2 0
Cannabinoid receptor 1 ligand AGN-PC-03I5TW family 3 12
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Cannabinoid receptor 1 ligand SureCN675796 family 5 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Corticotropin-releasing factor receptor 1 ligand 5-(2,4-dichlo... 5 17
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Cannabinoid receptor 1 ligand 1-(4-chlorophenyl)-2-(2,4-dichlo... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Sonic hedgehog protein and Smoothened homolog inhibitor N-(4,4... 2 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 13
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 8-... 6 2
Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8... 7 1
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Heat shock protein HSP 90-beta inhibitor N-[(9R)-4-(3H-imidazo... 1 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Sodium- and chloride-dependent glycine transporter 1 and Sodiu... 4 8
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 11 3
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 0
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
Corticotropin-releasing factor receptor 1 ligand 4-[(1R)-1-cyc... 5 6
Corticotropin-releasing factor receptor 1 ligand 4-(1-cyclopro... 3 0
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
Transient receptor potential cation channel subfamily V member... 4 0
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 5 0
Renin inhibitor AGN-PC-073MLF family 7 6
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Smoothened homolog inhibitor N-[4-chloro-3-(5-phenyl-1H-imidaz... 4 1
Substance-P receptor ligand SureCN7659714 family 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 2 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 4 2
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206058 family 5 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 6 3
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
B1 bradykinin receptor ligand N-[4-chloro-2-[[(1R)-1-[4-[3-flu... 5 5
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 5 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 5 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand pheny... 1 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Cathepsin K inhibitor SureCN4141224 family 3 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Neuropeptide Y receptor type 5 ligand SureCN6835211 family 1 2
Adenosine receptor A1 and Adenosine receptor A2b ligand SureCN... 2 3
Dipeptidyl peptidase 4 inhibitor 7-(aminomethyl)-6-(2-chloroph... 2 5
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 14 14
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03IU3J family 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 0
Tripeptidyl-peptidase 2 inhibitor (2S)-2-amino-1-[(2S)-5-chlor... 1 0
Adenosine kinase inhibitor SureCN8248615 family 2 3
Coagulation factor X inhibitor SureCN1652469 family 2 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 1 0
Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... 2 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
C-C chemokine receptor type 5 ligand 1-[4-(3-chlorophenyl)-4-[... 3 1
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 3-[3-... 4 9
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Prostaglandin E synthase inhibitor AGN-PC-014WPB family 1 0
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-... 9 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Progesterone receptor and Cytochrome P450 2C19 ligand AGN-PC-0... 8 3
Nociceptin receptor and Potassium voltage-gated channel subfam... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[(2... 3 1
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 9 0
Dihydrofolate reductase inhibitor 5-[(7-chloro-10-methylsulfan... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Fibroblast growth factor receptor 1 and Proto-oncogene tyrosin... 2 0
Tyrosine-protein kinase Lck and Tyrosine-protein kinase Lyn in... 1 0
P2X purinoceptor 7 inhibitor N-[(3-chloro-2-methylphenyl)methy... 7 0
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 inhibi... 3 7
Lysosomal Pro-X carboxypeptidase inhibitor 1-[6-[(2S)-2-(5,6-d... 2 0
Inosine-5'-monophosphate dehydrogenase inhibitor N-(4-chloroph... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 6-(2-... 2 0
Calpain-1 catalytic subunit inhibitor 2,6-dichloro-N-[(2S)-3,4... 1 0
Sodium channel protein type 9 subunit alpha and Sodium channel... 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00148726 CHEMBL524087 Bioactive Purine antagonist, 3c
CFAMM00148786 CHEMBL2436759 Bioactive N-[1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]piperidin-4-yl]-3-methylbutanamide
CFAMM00148747 CHEMBL2436762 Bioactive N-[1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]piperidin-4-yl]-2-cyclopentylacetamide
CFAMM00148814 CHEMBL498411 Bioactive Purine antagonist, 3f
CFAMM00148806 CHEMBL2180205 Bioactive tert-butyl N-[1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]piperidin-4-yl]carbamate
CFAMM00148785 CHEMBL2436756 Bioactive N-[1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]piperidin-4-yl]cyclohexanecarboxamide
CFAMM00148746 CHEMBL2436761 Bioactive N-[1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]piperidin-4-yl]-4-methylpentanamide
CFAMM00148813 CHEMBL562668 Bioactive otenabant
CFAMM00148895 CHEMBL496555 Bioactive Purine antagonist, 3g
CFAMM00148859 CHEMBL522720 Bioactive AGN-PC-00JIM6
CFAMM00148865 CHEMBL2180216 Bioactive tert-butyl N-[1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]-4-phenylpiperidin-4-yl]carbamate
CFAMM00148745 CHEMBL2436760 Bioactive N-[1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]piperidin-4-yl]cyclopentanecarboxamide
CFAMM00148783 CHEMBL2436754 Bioactive ethyl N-[1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]piperidin-4-yl]carbamate
CFAMM00148849 CHEMBL496293 Bioactive SureCN4690363
CFAMM00148789 CHEMBL2180215 Bioactive 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]-4-phenylpiperidine-4-carboxamide
CFAMM00148735 CHEMBL522235 Bioactive Purine antagonist, 3e
CFAMM00148787 CHEMBL2436758 Bioactive N-[1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]piperidin-4-yl]-2-cyclohexylacetamide
CFAMM00148830 DCL000508 Clinical Trial Drug CP-945598

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21760 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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