CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD304
Family Name Integrin alpha-4 Inhibitor Firategrast Family
No. of Seeds 3 No. of Other Members 93
Family Centroid CFAMM00149408 Functional Category Clinical Trial Drug with Natural Product
Superfamily Integrin alpha-4 Inhibitor Firategrast Superfamily
Class Class 65

Cousin Family NamesSeedsMembers
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
C-C chemokine receptor type 2 Ligand CCX915 Family 3 25
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
cAMP-dependent protein kinase type II-beta regulatory subunit ... 34 81
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Vascular endothelial growth factor receptor 1 Ligand C[homophe... 1 66
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Caspase-1 inhibitor 5-(3-carbamoylnaphthalen-2-yl)oxy-3-[[(2S)... 1 11
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Neprilysin inhibitor SureCN389939 family 5 6
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-7-[(4-ca... 3 14
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 12 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[4-(ben... 12 20
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Integrin beta-1 and Integrin alpha-4 inhibitor AGN-PC-074GDW f... 9 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-ethy... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(3-benz... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[1-(ben... 6 5
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 16 23
Prostaglandin E2 receptor EP4 subtype ligand 4-[(1S)-1-[[2-(tr... 2 1
Integrin alpha-4 and Integrin beta-7 inhibitor (2S)-2-[(2,6-di... 9 27
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 191
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 13 0
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 1 16
Caspase-1 and Caspase-8 inhibitor N-[(6S)-1-[2-[[(3S)-2-hydrox... 3 1
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 15 13
Caspase-1 inhibitor (3S)-3-[2-[3-(naphthalene-1-carbonylamino)... 13 5
Integrin alpha-4 and Integrin beta-7 inhibitor (2S)-3-[4-[5-(1... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-2... 2 21
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 4 1
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6627432 f... 6 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Growth hormone secretagogue receptor type 1 ligand SureCN76477... 2 1
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2-chlo... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2-chlo... 2 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 2 1
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 2 110
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00149458 CHEMBL162779 Bioactive AGN-PC-0754HY
CFAMM00149408 DCL000528 Clinical Trial Drug Firategrast
CFAMM00149377 DNC004593 Investigative Drug TR-14035

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21768 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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