CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD306
Family Name Reverse transcriptase Inhibitor IDX899 Family
No. of Seeds 2 No. of Other Members 118
Family Centroid CFAMM00149524 Functional Category Clinical Trial Drug with Natural Product
Superfamily Reverse transcriptase and Receptor-type tyrosine-protein kinase FLT3 Binder Superfamily
Class Class 952

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
D(4) dopamine receptor Ligand SPI-376 Family 7 84
CP-18770 family 6 27
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Adenosine receptor A3 and Potassium voltage-gated channel subf... 1 18
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Endothelin B receptor Ligand IRL-2500 Family 34 87
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6
Vasopressin V1b receptor ligand 2-[3-(3-chlorophenyl)-1-oxo-7-... 2 12
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Coagulation factor X and Prothrombin inhibitor SureCN763988 fa... 31 86
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Glycogen phosphorylase, liver form inhibitor 2,3-dichloro-N-[(... 2 14
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 2
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 3 14
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Coagulation factor X inhibitor N-[5-carbamoyl-2-[[(5-chlorothi... 8 8
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
Cannabinoid receptor 1 ligand 5-cyano-1-[(3,5-dichlorophenyl)m... 2 0
Coagulation factor X inhibitor 2-[4-[(5-chloro-1H-indole-2-car... 4 0
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Coagulation factor X inhibitor 2-carboxyindole 24 family 1 0
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
Translocator protein inhibitor N-(4-chlorophenyl)-N-methyl-2-(... 2 0
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 2 5
Coagulation factor X inhibitor SureCN8289965 family 4 5
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
D(3) dopamine receptor and Alpha-1D adrenergic receptor ligand... 1 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 2 9
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Cathepsin K inhibitor (1R,2R)-2-(6-chloro-1,3,4,5-tetrahydropy... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Motilin receptor ligand SureCN2768052 family 3 0
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 8
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 4 11
Pol polyprotein and Reverse transcriptase/RNaseH inhibitor CSI... 1 5
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 8
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
KiSS-1 receptor ligand SureCN5132924 family 2 4
Glycogen phosphorylase, liver form inhibitor SureCN5630210 family 2 0
Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1
Poly [ADP-ribose] polymerase 1 inhibitor SureCN4998361 family 1 1
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Translocator protein inhibitor 2-(7-Chloro-5-methyl-4-oxo-3-ph... 1 0
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Poly [ADP-ribose] polymerase 1 inhibitor SureCN3553433 family 22 0
Coagulation factor X inhibitor SureCN1251046 family 3 0
Coagulation factor X inhibitor SureCN1322298 family 2 1
Glycogen phosphorylase, liver form inhibitor 2-[(1R,2R)-2-[(5-... 3 2
Tyrosine-protein kinase inhibitor (4-chloro-1H-indol-2-yl)-[(3... 1 0
Neuromedin-K receptor ligand AGN-PC-00GCXP family 3 2
Malate dehydrogenase, mitochondrial inhibitor AGN-PC-0796ZJ fa... 1 0
(2S)-1-[(2S)-2-[(5-chloro-1-methylindole-2-carbonyl)amino]-4-m... 1 0
Putative NP ZINC06112695 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00149524 DCL000540 Clinical Trial Drug IDX899
CFAMM00149493 DNC005888 Investigative Drug JNJ-7777120

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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