CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD310
Family Name Neuronal acetylcholine receptor subunit alpha-4 Ligand Ispronicline Family
No. of Seeds 49 No. of Other Members 172
Family Centroid CFAMM00150030 Functional Category Clinical Trial Drug
Superfamily Neuronal acetylcholine receptor subunit alpha-4 Ligand Ispronicline Superfamily
Class Class 796

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 11
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
Histamine H3 receptor ligand SureCN4329918 family 4 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 2 0
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 2
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 4 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 3
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 0
Metabotropic glutamate receptor 5 and Cytochrome P450 1A2 liga... 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 4 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 6 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Hormone-sensitive lipase inhibitor AGN-PC-046LTD family 3 8
TGF-beta receptor type-1 ligand 2wou family 1 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 3
2-methylpyridin-3-ol NP 3-hydroxy-2-methylpyridine Family 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00150082 CHEMBL109767 Bioactive SureCN5172747
CFAMM00149938 CHEMBL94207 Bioactive SureCN7414932
CFAMM00150088 CHEMBL439766 Bioactive A-98593
CFAMM00150075 CHEMBL440195 Bioactive (R)-3-(Pyrrolidin-2-ylmethoxy)pyridine
CFAMM00150055 CHEMBL446410 Bioactive SureCN8437911
CFAMM00150029 CHEMBL123435 Bioactive 5-[[(2S)-azetidin-2-yl]methoxy]-2-iodopyridine
CFAMM00149998 CHEMBL97482 Bioactive 2-chloro-5-[[(2R,3R)-3-methylazetidin-2-yl]methoxy]pyridine
CFAMM00150022 CHEMBL441069 Bioactive SureCN905231
CFAMM00150094 CHEMBL109271 Bioactive (2R)-1-(6-chloropyridin-3-yl)oxypropan-2-amine
CFAMM00149964 CHEMBL537914 Bioactive SureCN6291509
CFAMM00150054 CHEMBL168780 Bioactive SureCN905202
CFAMM00150010 CHEMBL94670 Bioactive SureCN7407230
CFAMM00150106 CHEMBL98857 Bioactive AGN-PC-074S4Q
CFAMM00149950 CHEMBL96527 Bioactive SureCN7411369
CFAMM00149893 CHEMBL94877 Bioactive SureCN2437188
CFAMM00149990 CHEMBL97605 Bioactive AGN-PC-00DKKS
CFAMM00150014 CHEMBL125779 Bioactive 3-[[(2S)-azetidin-2-yl]methoxy]-2-bromopyridine
CFAMM00150027 CHEMBL99886 Bioactive (S)-5-IODO-3-[(2-AZETIDINYL)-METHOXY]PYRIDINE
CFAMM00149928 CHEMBL92038 Bioactive SureCN6583401
CFAMM00149942 CHEMBL114881 Bioactive (2R)-1-(6-chloropyridin-3-yl)oxy-N-methylpropan-2-amine
CFAMM00149983 CHEMBL97288 Bioactive SureCN7410743
CFAMM00150059 CHEMBL432643 Bioactive (2S)-1-(6-chloropyridin-3-yl)oxypropan-2-amine
CFAMM00149901 CHEMBL407258 Bioactive 5-[[(2S)-azetidin-2-yl]methoxy]-2-bromopyridine
CFAMM00150026 CHEMBL113240 Bioactive SureCN5173626
CFAMM00149941 CHEMBL97314 Bioactive 3-[[(2R)-azetidin-2-yl]methoxy]-5-methylpyridine
CFAMM00149968 CHEMBL318121 Bioactive SureCN4651868
CFAMM00150078 CHEMBL96604 Bioactive SureCN7409974
CFAMM00149948 CHEMBL327164 Bioactive SureCN7410388
CFAMM00149961 CHEMBL314303 Bioactive 5-[[(2R)-azetidin-2-yl]methoxy]-2-bromopyridine
CFAMM00149913 CHEMBL99367 Bioactive trimethyl(2-pyridin-3-yloxyethyl)azanium;chloride
CFAMM00150110 CHEMBL94304 Bioactive SureCN7408955
CFAMM00149906 CHEMBL94626 Bioactive [5-[[(2S)-azetidin-2-yl]methoxy]pyridin-3-yl]methanamine
CFAMM00150090 CHEMBL2207673 Bioactive Niodene
CFAMM00149933 CHEMBL449437 Bioactive MOLI001407
CFAMM00149960 CHEMBL318726 Bioactive SureCN8552509
CFAMM00150096 CHEMBL96370 Bioactive 3-[[(2S)-azetidin-2-yl]methoxy]-5-ethylpyridine
CFAMM00150083 CHEMBL2207676 Bioactive 3-[[(2S)-2,5-dihydro-1H-pyrrol-2-yl]methoxy]-2-fluoropyridine
CFAMM00149905 CHEMBL96431 Bioactive 3-[[(2S)-azetidin-2-yl]methoxy]-5-methylpyridine
CFAMM00149993 CHEMBL293435 Bioactive SureCN7368701
CFAMM00150038 DCL000675 Clinical Trial Drug ABT-089
CFAMM00150030 DCL000551 Clinical Trial Drug Ispronicline
CFAMM00150095 DNC000127 Investigative Drug A-85380
CFAMM00149936 DNC000133 Investigative Drug ABT-594
CFAMM00149900 DNC006435 Investigative Drug N-methyl-2-(pyridin-3-yloxy)ethanamine
CFAMM00149967 DNC014096 Investigative Drug (S)-3-(azetidin-2-ylmethoxy)-2-fluoropyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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