CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name 5-hydroxytryptamine receptor Ligand Lu AA21004 Family
No. of Seeds 13 No. of Other Members 39
Family Centroid CFAMM00150451 Functional Category Clinical Trial Drug
Superfamily 5-hydroxytryptamine receptor Ligand Lu AA21004 Superfamily
Class Class 1028

Cousin Family NamesSeedsMembers
Calmodulin inhibitor phenothiazine derivative Trifluoperazine ... 3 30
D(2) dopamine receptor Ligand phenothiazine analog Prochlorper... 4 25
Muscarinic acetylcholine receptor M5 ligand phenothiazine deri... 8 37
Alpha-1B adrenergic receptor Ligand Propericiazine Family 2 0
Histamine H1 receptor ligand phenothiazine derivative Mequitaz... 3 2
Mannose-6-phosphate isomerase Inhibitor Sulfoxone Family 3 20
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
5-hydroxytryptamine receptor 6 Ligand 4-(4-benzenesulfonamidop... 4 5
5-hydroxytryptamine receptor 2A Ligand Cinanserin Family 3 27
Cholinesterase Inhibitor N-cyclohexyl-1'h-phenothiazine-1'-car... 7 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 6 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 4 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 18 12
Sodium-dependent serotonin transporter and Transporter inhibit... 4 0
5-hydroxytryptamine receptor 2A and Alpha-2B adrenergic recept... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 4 1
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sodium-dependent serotonin transporter and Transporter inhibit... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 4 1
5-hydroxytryptamine receptor 1A ligand AGN-PC-00JBJI family 1 1


External ID

Functional Category

Molecule Name

CFAMM00150439 CHEMBL2204360 Bioactive 1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine;hydrochloride
CFAMM00150438 CHEMBL2204363 Bioactive 1-[2-(2-chloro-4-methylphenyl)sulfanylphenyl]piperazine;hydrochloride
CFAMM00150460 CHEMBL2205038 Bioactive 1-[2-(4-chlorophenyl)sulfanyl-5-methylphenyl]piperazine;hydrochloride
CFAMM00150471 CHEMBL190703 Bioactive AGN-PC-005LPB
CFAMM00150433 CHEMBL22183 Bioactive SureCN1644204
CFAMM00150470 CHEMBL190700 Bioactive AGN-PC-007HAL
CFAMM00150469 CHEMBL189367 Bioactive 2-[2-[(dimethylamino)methyl]phenyl]sulfanyl-5-ethylaniline
CFAMM00150431 CHEMBL189375 Bioactive 5-ethyl-2-[2-(methylaminomethyl)phenyl]sulfanylaniline
CFAMM00150468 CHEMBL2205054 Bioactive 1-[2-(3,4-dimethylphenyl)sulfanylphenyl]piperazine;hydrochloride
CFAMM00150430 CHEMBL2204357 Bioactive 1-[2-(2,3-dimethylphenyl)sulfanylphenyl]piperazine;hydrochloride
CFAMM00150451 DCL000555 Clinical Trial Drug Lu AA21004
CFAMM00150446 DNCL003062 Clinical Trial Drug Vortioxetine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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