CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD318
Family Name Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family
No. of Seeds 8 No. of Other Members 43
Family Centroid CFAMM00150545 Functional Category Clinical Trial Drug
Superfamily Poly [ADP-ribose] polymerase 1 and Serine/threonine-protein kinase Chk1 Binder Superfamily
Class Class 1032

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Hepatocyte growth factor receptor Ligand MK-8033 Family 19 42
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 4
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Transient receptor potential cation channel subfamily V member... 6 23
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Adenosine receptor A3 Ligand 2-phenyl-2h-pyrazolo[4,3-d]pyrimi... 2 7
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Glutamate receptor 1 Ligand Piriqualone Family 8 67
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 3 59
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
Coagulation factor X inhibitor AGN-PC-02WFR7 family 7 13
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 7 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00150545 DCL000571 Clinical Trial Drug MK-4827
CFAMM00150537 DNC010732 Investigative Drug 2-(3-Chlorophenyl)-2H-indazole-7-carboxamide
CFAMM00150536 DNC010733 Investigative Drug 2-(2-Chlorophenyl)-2H-indazole-7-carboxamide
CFAMM00150535 DNC010734 Investigative Drug 2-Benzyl-2H-indazole-7-carboxamide
CFAMM00150567 DNC010268 Investigative Drug 2-phenyl-2H-indazole-7-carboxamide
CFAMM00150539 DNC007578 Investigative Drug 2-p-tolyl-2H-pyrazolo[3,4-c]quinolin-4(5H)-one
CFAMM00150572 DNC007577 Investigative Drug 2-phenyl-2H-pyrazolo[3,4-c]quinolin-4(5H)-one
CFAMM00150538 DNC010731 Investigative Drug 2-(4-Chlorophenyl)-2H-indazole-7-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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