CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Hepatocyte growth factor receptor Ligand MK-8033 Family
No. of Seeds 19 No. of Other Members 42
Family Centroid CFAMM00150763 Functional Category Clinical Trial Drug
Superfamily Hepatocyte growth factor receptor Ligand MK-8033 Superfamily
Class Class 845

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Interleukin-1 beta and Interleukin-6 Inhibitor Ibudilast Family 2 11
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Potassium voltage-gated channel subfamily H member 2 Ligand E-... 1 4
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
DNA topoisomerase 2-beta Inhibitor 2-(2-hydroxyethyl)anthra[1,... 2 3
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 29
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Hepatocyte growth factor receptor ligand N-(11-oxo-2-thiophen-... 1 1
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
Type-1 angiotensin II receptor ligand 2-[[(5-ethylpyrazolo[1,5... 1 0
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
Hepatocyte growth factor receptor ligand N-[2-(1,4-dioxa-8-aza... 1 0
Hepatocyte growth factor receptor ligand N-[2-(3-chlorophenyl)... 2 2
Hepatocyte growth factor receptor ligand 1-methyl-N-[2-(1-meth... 1 0
Hepatocyte growth factor receptor and Macrophage-stimulating p... 1 0
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 7 2
G1/S-specific cyclin-E2 and G1/S-specific cyclin-E1 inhibitor ... 1 0


External ID

Functional Category

Molecule Name

CFAMM00150792 CHEMBL1802907 Bioactive 2-(1-methylpyrazol-4-yl)-9-(methylsulfamoylamino)benzo[1,2]cyclohepta[2,4-b]pyridin-11-one
CFAMM00150784 CHEMBL1802908 Bioactive 9-(diethylsulfamoylamino)-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
CFAMM00150764 CHEMBL2323769 Bioactive N-[(2-chlorophenyl)methyl]-1-[2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl]methanesulfonamide
CFAMM00150799 CHEMBL2323777 Bioactive 1-[2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl]-N-[(1-oxidopyridin-1-ium-2-yl)methyl]methanesulfonamide
CFAMM00150783 CHEMBL2323782 Bioactive N-cyclohexyl-1-[2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl]methanesulfonamide
CFAMM00150797 CHEMBL2323774 Bioactive 1-[2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl]-N-(pyridin-4-ylmethyl)methanesulfonamide
CFAMM00150790 CHEMBL1802904 Bioactive 9-(dimethylsulfamoylamino)-2-[1-(1-ethylpiperidin-4-yl)pyrazol-4-yl]-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
CFAMM00150748 CHEMBL1802602 Bioactive N-[2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl]methanesulfonamide
CFAMM00150782 CHEMBL2323783 Bioactive 1-[11-oxo-2-(1-piperidin-4-ylpyrazol-4-yl)benzo[1,2]cyclohepta[2,4-b]pyridin-9-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide
CFAMM00150796 CHEMBL2323773 Bioactive 1-[2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl]-N-(pyridin-3-ylmethyl)methanesulfonamide
CFAMM00150741 CHEMBL2324128 Bioactive N-[(2,4-difluorophenyl)methyl]-1-[2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl]methanesulfonamide
CFAMM00150754 CHEMBL1802830 Bioactive 9-(dimethylsulfamoylamino)-11-oxo-2-(1-propylpyrazol-4-yl)benzo[1,2]cyclohepta[2,4-b]pyridine
CFAMM00150795 CHEMBL2323772 Bioactive 1-[2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl]-N-(1,2-thiazol-4-ylmethyl)methanesulfonamide
CFAMM00150780 CHEMBL2323781 Bioactive 2-(1-methylpyrazol-4-yl)-9-[methyl(pyridin-2-ylmethylsulfamoyl)amino]-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
CFAMM00150794 CHEMBL2323771 Bioactive 1-[2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl]-N-[(2-methylpyrimidin-4-yl)methyl]methanesulfonamide
CFAMM00150786 CHEMBL1802829 Bioactive 9-(dimethylsulfamoylamino)-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
CFAMM00150793 CHEMBL2323770 Bioactive 1-[2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl]-N-(pyridazin-3-ylmethyl)methanesulfonamide
CFAMM00150785 CHEMBL1802909 Bioactive 9-[[methyl(pyrazin-2-ylmethyl)sulfamoyl]amino]-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
CFAMM00150763 DCL000574 Clinical Trial Drug MK-8033

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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