CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD328
Family Name Coagulation factor X Inhibitor Otamixaban Family
No. of Seeds 9 No. of Other Members 21
Family Centroid CFAMM00151205 Functional Category Clinical Trial Drug with Natural Product
Superfamily Coagulation factor X Inhibitor Otamixaban Superfamily
Class Class 78

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Thromboxane A2 receptor Ligand Ridogrel Family 7 83
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
HIV-1 protease Inhibitor Atazanavir Family 16 58
26S proteasome Inhibitor Bortezomib Family 7 65
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Prothrombin Inhibitor Dabigatran Family 7 182
Histone deacetylase 1 Inhibitor MS-275 Family 4 41
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Thromboxane A2 receptor Ligand Bibv 308 Family 14 40
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
ABC294640 family 5 75
CP-18770 family 6 27
Eluxadoline family 4 85
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
PF-4136309 family 16 27
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Thromboxane-A synthase Inhibitor CGS-22652 Family 37 95
Integrin beta-3 Inhibitor Elarofiban Family 28 45
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Renin Inhibitor CP-305202 Family 9 30
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Pol polyprotein inhibitor AC1LAD48 family 19 5
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Coagulation factor X inhibitor (2S)-(3'-AMIDINO-3-BIPHENYL)-5-... 1 0
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 22
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Cathepsin K inhibitor [(3S)-1-(1H-indole-6-carbonyl)-4,4-dimet... 2 4
Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 rec... 8 17
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Mitogen-activated protein kinase 14 and Mast/stem cell growth ... 4 4
Glucocorticoid receptor ligand SureCN3283777 family 1 0
Integrin alpha-V and Integrin beta-5 inhibitor SureCN6563167 f... 2 10
Cholecystokinin receptor type A ligand A-65186 family 2 6
Plasmepsin-1 and Plasmepsin-2 inhibitor Statine-like inhibitor... 13 5
Pol polyprotein inhibitor N-[3-[[(4R,5R,6R)-4-benzyl-5-hydroxy... 1 0
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-05... 2 2
Thromboxane-A synthase and Thromboxane A2 receptor ligand (E)-... 2 1
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 1
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Peptide deformylase inhibitor (2R)-N-[(2S)-3,3-dimethyl-1-oxo-... 2 1
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 10 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 4
C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 4 7
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QM95 family 1 1
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Substance-K receptor ligand N-[1-[[(2S)-1-[[1-(oxan-4-ylmethyl... 3 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Prothrombin and Trypsin-1 inhibitor 1-[2-(4-benzylpiperidin-1-... 2 2
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Delta-type opioid receptor and Potassium voltage-gated channel... 2 0
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 3 1
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
B1 bradykinin receptor ligand AGN-PC-00CTAF family 1 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[[(E)-3-(3,4-dichlo... 6 1
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
B1 bradykinin receptor ligand methyl 2-[4-[(1R)-1-[[3-[(2-cyan... 8 7
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C9 liga... 2 6
Motilin receptor ligand SureCN2768052 family 3 0
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Rho-associated protein kinase 2 inhibitor 2-hydroxyethyl 3-[2-... 2 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 1 2
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Substance-P receptor ligand N-[[3,5-bis(trifluoromethyl)phenyl... 1 3
Pol polyprotein inhibitor 183854-15-1 family 3 0
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 2
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 1
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Hydroxycarboxylic acid receptor 2 ligand AGN-PC-04RSPS family 4 0
ATP-sensitive inward rectifier potassium channel 11 ligand N-[... 1 1
Cytochrome P450 2C19 inhibitor AGN-PC-07CPMJ family 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-[[2-[3... 4 0
Pol polyprotein inhibitor AC1LA6OV family 1 2
heptanamide NP ZINC08740384 Family 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00151228 CHEMBL46969 Bioactive methyl (2R,3R)-2-[(3-carbamimidoylphenyl)methyl]-3-[[4-(1-oxidopyridin-1-ium-3-yl)benzoyl]amino]butanoate
CFAMM00151203 CHEMBL415907 Bioactive methyl (2R,3R)-2-[(3-carbamimidoylphenyl)methyl]-3-[(4-pyridin-3-ylbenzoyl)amino]butanoate
CFAMM00151235 CHEMBL47207 Bioactive methyl (2R,3R)-2-[(3-carbamimidoylphenyl)methyl]-3-[[4-(1-methylpyridin-1-ium-4-yl)benzoyl]amino]butanoate
CFAMM00151234 CHEMBL44586 Bioactive methyl (2R,3R)-2-[(3-carbamimidoylphenyl)methyl]-3-[[4-(1-methylpyridin-1-ium-2-yl)benzoyl]amino]butanoate
CFAMM00151225 CHEMBL295010 Bioactive methyl (2R,3R)-2-[(3-carbamimidoylphenyl)methyl]-3-[(4-pyridin-2-ylbenzoyl)amino]butanoate
CFAMM00151217 CHEMBL295454 Bioactive methyl (2R,3R)-2-[(3-carbamimidoylphenyl)methyl]-3-[[4-(1-methylpyridin-1-ium-3-yl)benzoyl]amino]butanoate
CFAMM00151208 CHEMBL46708 Bioactive methyl (2R,3R)-2-[(3-carbamimidoylphenyl)methyl]-3-[[4-(1-oxidopyridin-1-ium-2-yl)benzoyl]amino]butanoate
CFAMM00151231 CHEMBL296046 Bioactive SureCN10072203
CFAMM00151205 DCL000586 Clinical Trial Drug Otamixaban

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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