CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2 Inhibitor Pazopanib + Tyverb/tykerb Family
No. of Seeds 8 No. of Other Members 31
Family Centroid CFAMM00151250 Functional Category Clinical Trial Drug
Superfamily Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2 Inhibitor Pazopanib + Tyverb/tykerb Superfamily
Class Class 1037

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 50 36
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Transient receptor potential cation channel subfamily V member... 2 1
5-hydroxytryptamine receptor 2A and Alpha-1A adrenergic recept... 4 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Fatty-acid amide hydrolase 1 and Cytochrome P450 2D6 inhibitor... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Beta-1 adrenergic receptor ligand 1-[2-[[(2S)-3-(2-cyanophenox... 4 1
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 11 8
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 2 7
P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... 4 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Melanin-concentrating hormone receptor 1 ligand 3-[4-fluoro-3-... 1 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 25 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Acyl-CoA:cholesterol acyltransferase inhibitor 3-(2-chloro-6-m... 4 6
Corticotropin-releasing factor receptor 1 ligand N-[(1R,2S)-2-... 3 0
Coagulation factor X and Cationic trypsin inhibitor SureCN6578... 4 11
Histidine-rich protein PFHRP-II inhibitor AGN-PC-075SYG family 1 0
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-073... 1 1


External ID

Functional Category

Molecule Name

CFAMM00151273 CHEMBL14563 Bioactive SB242084
CFAMM00151267 CHEMBL54719 Bioactive 5-methyl-N-[6-(pyridin-2-ylmethoxy)pyridin-3-yl]-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide
CFAMM00151239 CHEMBL59097 Bioactive 5-chloro-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide
CFAMM00151270 CHEMBL299726 Bioactive 6-chloro-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide
CFAMM00151247 CHEMBL299530 Bioactive AGN-PC-073T4Z
CFAMM00151249 CHEMBL54769 Bioactive AGN-PC-073T6U
CFAMM00151255 CHEMBL433060 Bioactive 5-iodo-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide
CFAMM00151250 DCL000589 Clinical Trial Drug Pazopanib + Tyverb/Tykerb

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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