CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD332
Family Name Metabotropic glutamate receptor 1 Ligand PF-1913539 Family
No. of Seeds 130 No. of Other Members 817
Family Centroid CFAMM00151870 Functional Category Clinical Trial Drug with Natural Product
Superfamily Metabotropic glutamate receptor 1 Ligand PF-1913539 Superfamily
Class Class 1038

Cousin Family NamesSeedsMembers
Kinetin family 2 39
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
MK-3328 family 2 32
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Adenosine receptor A1 and Adenosine receptor A2a Ligand CGS-15... 24 47
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 4 32
Adenosine receptor A1 and Adenosine receptor A2a Ligand ZM-241... 2 5
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family 39 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 1
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 0
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Adenosine receptor A2a ligand SureCN6867940 family 13 13
Receptor-type tyrosine-protein kinase FLT3 and Hepatocyte grow... 7 56
5-hydroxytryptamine receptor 6 ligand F1609-0206 family 2 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 10 3
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 9 inhibitor Su... 3 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 4 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
DNA-(apurinic or apyrimidinic site) lyase and Nuclear receptor... 2 10
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 8 0
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Prelamin-A/C and Prothrombin inhibitor (3-Furan-2-yl-5-methyls... 2 1
Adenosine receptor A3 and Adenosine receptor A2b ligand CHEMBL... 5 0
Survival motor neuron protein and Neuropeptide S receptor liga... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 7 4
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 5 8
Adenosine receptor A2a ligand 5-N-[[(2R)-1-[(2-chloro-3,6-difl... 7 9
Adenosine receptor A2a ligand 5-[[[(2R)-1-[(2-chloropyridin-4-... 5 0
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 6
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Adenosine receptor A2a ligand 7-(3,4-dimethoxyphenyl)-2-(furan... 6 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 2 3
Adenosine receptor A3 ligand CHEMBL1834703 family 2 1
Vascular endothelial growth factor receptor 1 and Vascular end... 11 38
Histamine H4 receptor ligand 8-fluoro-4-[(3R)-3-(methylamino)p... 6 1
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Prothrombin and Coagulation factor X inhibitor SureCN6929748 f... 6 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 3
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Adenosine receptor A3 ligand CHEMBL211055 family 3 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 1 0
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
Scavenger receptor class B member 1 ligand 2-[9-[3-(4,6-dimeth... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 6
Vascular endothelial growth factor receptor 2 and Platelet-der... 16 11
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 5-[(7S... 6 1
Adenosine receptor A2a ligand 5-[(7S,9aS)-7-[(2-fluorophenoxy)... 5 4
P2X purinoceptor 7 inhibitor SureCN110566 family 1 0
Adenosine receptor A1 ligand ethyl 1-(2-chloro-2-phenylethyl)-... 5 1
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 4
Mitogen-activated protein kinase kinase kinase 7 and TGF-beta-... 3 14
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Tyrosine-protein kinase ITK/TSK and Aurora kinase B inhibitor ... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 3
Adenosine receptor A2a ligand 3-[(2-bromophenyl)methyl]-8-(fur... 2 0
Adenosine receptor A2a ligand 8-(furan-2-yl)-3-[2-[4-(1,3-thia... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 25 5
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 1 2
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Adenosine receptor A3 and Adenosine receptor A2a ligand (3R,4S... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-075YVI ... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 1 1
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Adenosine receptor A2a ligand SureCN8368237 family 1 0
Adenosine receptor A2a ligand AGN-PC-02Z2S3 family 3 0
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-03J2ZU f... 1 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 2
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Adenosine receptor A2a and Adenosine receptor A1 ligand triazi... 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 0
Serine/threonine-protein kinase Chk1 and Cyclin-A2 inhibitor S... 1 0
Aurora kinase B and Aurora kinase A inhibitor N-(furan-2-ylmet... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00151377 CHEMBL2181150 Bioactive CHEMBL2181150
CFAMM00152058 CHEMBL482078 Bioactive AGN-PC-078ZFH
CFAMM00151767 CHEMBL22202 Bioactive CHEMBL22202
CFAMM00151301 CHEMBL469673 Bioactive CHEMBL469673
CFAMM00151565 CHEMBL2071048 Bioactive CHEMBL2071048
CFAMM00151644 CHEMBL2180932 Bioactive CHEMBL2180932
CFAMM00151605 CHEMBL17094 Bioactive SureCN5333130
CFAMM00151515 CHEMBL166684 Bioactive AGN-PC-00F1JO
CFAMM00151974 CHEMBL401242 Bioactive CHEMBL401242
CFAMM00151673 CHEMBL164686 Bioactive CHEMBL164686
CFAMM00151733 CHEMBL240211 Bioactive CHEMBL240211
CFAMM00151746 CHEMBL400214 Bioactive CHEMBL400214
CFAMM00151808 CHEMBL164647 Bioactive CHEMBL164647
CFAMM00151883 CHEMBL1935762 Bioactive CHEMBL1935762
CFAMM00152202 CHEMBL241110 Bioactive CHEMBL241110
CFAMM00151925 CHEMBL520782 Bioactive AGN-PC-04TF86
CFAMM00151890 CHEMBL469877 Bioactive AGN-PC-078UPP
CFAMM00152256 CHEMBL1771603 Bioactive AGN-PC-0A9UTY
CFAMM00151951 CHEMBL203998 Bioactive CHEMBL203998
CFAMM00151571 CHEMBL2071040 Bioactive CHEMBL2071040
CFAMM00152222 CHEMBL22500 Bioactive CHEMBL22500
CFAMM00151521 CHEMBL302765 Bioactive MRE 3008-F20
CFAMM00151679 CHEMBL2181160 Bioactive CHEMBL2181160
CFAMM00151693 CHEMBL519784 Bioactive AGN-PC-039OCV
CFAMM00151780 CHEMBL164509 Bioactive CHEMBL164509
CFAMM00151389 CHEMBL175986 Bioactive AGN-PC-0058BC
CFAMM00151882 CHEMBL1935763 Bioactive CHEMBL1935763
CFAMM00151643 CHEMBL2180933 Bioactive CHEMBL2180933
CFAMM00151706 CHEMBL2070885 Bioactive CHEMBL2070885
CFAMM00151577 CHEMBL2071046 Bioactive CHEMBL2071046
CFAMM00152201 CHEMBL423542 Bioactive SureCN4824435
CFAMM00151589 CHEMBL513364 Bioactive SureCN8275590
CFAMM00152214 CHEMBL178589 Bioactive SureCN6047316
CFAMM00151341 CHEMBL22822 Bioactive CHEMBL22822
CFAMM00151306 CHEMBL469674 Bioactive SureCN13594904
CFAMM00151557 CHEMBL472110 Bioactive SureCN8275581
CFAMM00151395 CHEMBL511446 Bioactive CHEMBL511446
CFAMM00151527 CHEMBL281601 Bioactive CHEMBL281601
CFAMM00151662 CHEMBL180109 Bioactive SureCN6047331
CFAMM00151814 CHEMBL1258307 Bioactive AGN-PC-09M58A
CFAMM00151917 CHEMBL362038 Bioactive AGN-PC-008GS6
CFAMM00151678 CHEMBL2181161 Bioactive CHEMBL2181161
CFAMM00151375 CHEMBL2181152 Bioactive CHEMBL2181152
CFAMM00151765 CHEMBL572765 Bioactive CHEMBL572765
CFAMM00151867 CHEMBL351211 Bioactive CHEMBL351211
CFAMM00151642 CHEMBL2180934 Bioactive CHEMBL2180934
CFAMM00151731 CHEMBL240212 Bioactive CHEMBL240212
CFAMM00152213 CHEMBL165620 Bioactive CHEMBL165620
CFAMM00151910 CHEMBL239809 Bioactive CHEMBL239809
CFAMM00151603 CHEMBL239817 Bioactive SureCN12404398
CFAMM00151511 CHEMBL278812 Bioactive CHEMBL278812
CFAMM00151744 CHEMBL240846 Bioactive CHEMBL240846
CFAMM00152091 CHEMBL164381 Bioactive CHEMBL164381
CFAMM00151381 CHEMBL2181154 Bioactive CHEMBL2181154
CFAMM00151305 CHEMBL16867 Bioactive SureCN4759270
CFAMM00151798 CHEMBL329791 Bioactive SureCN2283773
CFAMM00152179 CHEMBL349240 Bioactive SureCN13746121
CFAMM00151333 CHEMBL359473 Bioactive CHEMBL359473
CFAMM00151963 CHEMBL315150 Bioactive SureCN4758537
CFAMM00151361 CHEMBL577183 Bioactive AGN-PC-07CNNS
CFAMM00151691 CHEMBL16894 Bioactive SureCN4758498
CFAMM00151764 CHEMBL400215 Bioactive CHEMBL400215
CFAMM00151778 CHEMBL165560 Bioactive CHEMBL165560
CFAMM00151450 CHEMBL383689 Bioactive AGN-PC-00E3HC
CFAMM00151312 CHEMBL481771 Bioactive AGN-PC-078ZG3
CFAMM00151654 CHEMBL534936 Bioactive AGN-PC-00CC8R
CFAMM00151575 CHEMBL2071044 Bioactive CHEMBL2071044
CFAMM00152034 CHEMBL519111 Bioactive AGN-PC-078ZG4
CFAMM00151894 CHEMBL418564 Bioactive CHEMBL418564
CFAMM00151986 CHEMBL281805 Bioactive CHEMBL281805
CFAMM00151935 CHEMBL278906 Bioactive SureCN1755132
CFAMM00151539 CHEMBL342059 Bioactive SureCN4758522
CFAMM00151697 CHEMBL2069325 Bioactive CHEMBL2069325
CFAMM00151723 CHEMBL479784 Bioactive AGN-PC-078ZIC
CFAMM00152131 CHEMBL2112948 Bioactive CHEMBL2112948
CFAMM00151825 CHEMBL383714 Bioactive AGN-PC-00ADXG
CFAMM00151419 CHEMBL1935745 Bioactive CHEMBL1935745
CFAMM00151595 CHEMBL512133 Bioactive AGN-PC-078UQY
CFAMM00151839 CHEMBL168018 Bioactive AGN-PC-00FMIV
CFAMM00151297 CHEMBL351285 Bioactive SureCN13745468
CFAMM00151640 CHEMBL2180936 Bioactive CHEMBL2180936
CFAMM00151954 CHEMBL164325 Bioactive CHEMBL164325
CFAMM00151574 CHEMBL2071043 Bioactive CHEMBL2071043
CFAMM00152184 CHEMBL348975 Bioactive CHEMBL348975
CFAMM00151941 CHEMBL349954 Bioactive AGN-PC-00F26S
CFAMM00151585 CHEMBL145623 Bioactive CHEMBL145623
CFAMM00151908 CHEMBL469893 Bioactive SureCN8367159
CFAMM00152225 CHEMBL275636 Bioactive CHEMBL275636
CFAMM00152290 CHEMBL349611 Bioactive CHEMBL349611
CFAMM00152303 CHEMBL324735 Bioactive CHEMBL324735
CFAMM00152047 CHEMBL165778 Bioactive CHEMBL165778
CFAMM00151742 CHEMBL330286 Bioactive SureCN2283833
CFAMM00151845 CHEMBL481956 Bioactive AGN-PC-078ZHJ
CFAMM00151538 CHEMBL422820 Bioactive SureCN1389191
CFAMM00151646 CHEMBL2180930 Bioactive CHEMBL2180930
CFAMM00151379 CHEMBL2181156 Bioactive CHEMBL2181156
CFAMM00152190 CHEMBL344706 Bioactive SureCN4759841
CFAMM00151567 CHEMBL304726 Bioactive SureCN4758021
CFAMM00151344 CHEMBL2180906 Bioactive CHEMBL2180906
CFAMM00151675 CHEMBL164685 Bioactive CHEMBL164685
CFAMM00151735 CHEMBL165044 Bioactive AGN-PC-00GYLG
CFAMM00152116 CHEMBL352796 Bioactive AGN-PC-00EYLG
CFAMM00152232 CHEMBL209479 Bioactive AGN-PC-00E39G
CFAMM00151531 CHEMBL175474 Bioactive AGN-PC-004IC8
CFAMM00151702 CHEMBL362190 Bioactive AGN-PC-009DWL
CFAMM00151652 CHEMBL357663 Bioactive CHEMBL357663
CFAMM00151337 CHEMBL350261 Bioactive CHEMBL350261
CFAMM00151984 CHEMBL351075 Bioactive CHEMBL351075
CFAMM00151682 CHEMBL513030 Bioactive CHEMBL513030
CFAMM00152224 CHEMBL519282 Bioactive AGN-PC-078ZGT
CFAMM00151631 CHEMBL22320 Bioactive CHEMBL22320
CFAMM00151645 CHEMBL2180931 Bioactive CHEMBL2180931
CFAMM00152025 CHEMBL137879 Bioactive SureCN4759566
CFAMM00151959 CHEMBL22241 Bioactive CHEMBL22241
CFAMM00152279 CHEMBL175494 Bioactive AGN-PC-075BHL
CFAMM00152115 CHEMBL470089 Bioactive SureCN8365698
CFAMM00151823 CHEMBL164992 Bioactive AGN-PC-00GNMH
CFAMM00152216 CHEMBL481132 Bioactive AGN-PC-039OD2
CFAMM00152231 CHEMBL65271 Bioactive SureCN2284068
CFAMM00151991 CHEMBL332091 Bioactive SureCN1389221
CFAMM00151638 CHEMBL118923 Bioactive SureCN4820060
CFAMM00152065 CHEMBL512891 Bioactive CHEMBL512891
CFAMM00151336 CHEMBL471554 Bioactive SureCN8368207
CFAMM00151572 CHEMBL2071041 Bioactive CHEMBL2071041
CFAMM00152045 CHEMBL175871 Bioactive CHEMBL175871
CFAMM00151545 DCL000979 Clinical Trial Drug SCH 420814
CFAMM00151870 DCL000594 Clinical Trial Drug PF-1913539
CFAMM00151329 DNC007923 Investigative Drug SCH-412348
CFAMM00152012 DNC004411 Investigative Drug SCH-442416
CFAMM00152163 DNC004283 Investigative Drug SCH-63390

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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