CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD338
Family Name Glucokinase Inhibitor R7201 Family
No. of Seeds 22 No. of Other Members 105
Family Centroid CFAMM00152415 Functional Category Clinical Trial Drug with Natural Product
Superfamily Glucokinase Inhibitor R7201 Superfamily
Class Class 1042

Cousin Family NamesSeedsMembers
Tyrosinase Inhibitor Monobenzone Family 6 197
Salicin family 5 629
Sodium/glucose cotransporter 2 Inhibitor Empagliflozin Family 32 52
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Urokinase-type plasminogen activator Inhibitor Amediplase Family 1 28
TS-071 family 8 36
DNA topoisomerase 2-beta Inhibitor Howiinol A (ghm-10) Family 1 42
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Tubulin beta chain Inhibitor Combretastatin Family 3 5
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Sodium/glucose cotransporter 2 Inhibitor Maackiain Family 1 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Protein kinase C alpha type Inhibitor Acetoside Family 5 39
Sodium-dependent noradrenaline transporter Inhibitor Polygalat... 2 87
Cytochrome P450 3A4 Inhibitor (8r,8'r,9's)-5-methoxyclusin Family 6 20
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Acetylcholinesterase Inhibitor 4-formylphenyl-o-beta-d-ribopyr... 2 17
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Sodium/glucose cotransporter 2 inhibitor (2S,3R,4R,5S,6R)-2-[4... 9 1
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
Estrogen receptor beta and Estrogen receptor ligand 3-fluoro-4... 6 42
Sodium/glucose cotransporter 1 and Sodium/glucose cotransporte... 4 1
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-[(1S,3S,5... 2 0
Vitamin D3 receptor ligand (3E,5E)-6-[3-[[3,4-bis(hydroxymethy... 2 4
Sodium/glucose cotransporter 2 inhibitor (2S,3R,4R,5S,6R)-2-[5... 1 1
Sodium/glucose cotransporter 2 inhibitor (2S,3R,4R,5S,6R)-2-[3... 1 0
Vitamin D3 receptor ligand (1R,3S,5Z)-5-[(2E)-2-[(3aS,7aR)-1-[... 1 2
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 1 0
Low affinity sodium-glucose cotransporter and Sodium/glucose c... 1 0
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 18
Pol polyprotein inhibitor AGN-PC-01UWQ4 family 4 5
Substance-P receptor ligand AGN-PC-01XQZG family 2 13
Arachidonate 5-lipoxygenase inhibitor AGN-PC-00PO2W family 1 1
Prostaglandin G/H synthase 2 inhibitor (2R,3S,5R)-2,3-bis(4-fl... 1 1
Acetylcholinesterase inhibitor (2R,3S,4S,5R,6S)-2-(hydroxymeth... 1 1
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
Acenes Metabolite Naphthalene epoxide Family 3 49
Glycosyl Compounds Metabolite Taxiphyllin Family 2 9
Acetals Metabolite 1-Benzyloxy-1-(2-methoxyethoxy)ethane Family 3 50
Phenols and Derivatives Metabolite 2-Ethoxy-4-(4-methyl-1,3-di... 1 0
Toluenes Metabolite Tolualdehyde glyceryl acetal Family 3 5
3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxole NP (3ar,5r,6s,6ar)... 18 6
2-methyl-6-phenyl-5-prop-1-en-2-yloxane-2-carbonitrile NP ZINC... 8 11
[(2S,3aR,5S,6S,6aR)-2-cyano-2-methyl-6-trityloxy-3a,5,6,6a-tet... 1 0
2-(4-methoxyphenyl)-10,10-dimethyl-1,3,9-trioxaspiro[5.5]undec... 4 19


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00152447 CHEMBL2172386 Bioactive (3S,3'R,4'S,5'S,6'R)-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)-6-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
CFAMM00152465 CHEMBL570868 Bioactive SureCN3798045
CFAMM00152375 CHEMBL2172491 Bioactive (3S,3'R,4'S,5'S,6'R)-6'-(hydroxymethyl)-5-[(4-methylphenyl)methyl]spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
CFAMM00152446 CHEMBL2172387 Bioactive (3S,3'R,4'S,5'S,6'R)-5-[(4-ethylphenyl)methyl]-6-ethynyl-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
CFAMM00152464 CHEMBL584689 Bioactive SureCN1314781
CFAMM00152445 CHEMBL2172385 Bioactive (3S,3'R,4'S,5'S,6'R)-6'-(hydroxymethyl)-5-[(4-methylsulfanylphenyl)methyl]spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
CFAMM00152397 CHEMBL1086408 Bioactive SureCN13395760
CFAMM00152462 CHEMBL567276 Bioactive SureCN1315741
CFAMM00152528 CHEMBL2017954 Bioactive (2S,3R,4R,5S,6R)-2-[3-[(4-ethylphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
CFAMM00152450 CHEMBL2172389 Bioactive (3S,3'R,4'S,5'S,6'R)-6'-(hydroxymethyl)-5-[(4-methoxyphenyl)methyl]spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
CFAMM00152378 CHEMBL2172494 Bioactive (3S,3'R,4'S,5'S,6'R)-5-[(4-cyclopropylphenyl)methyl]-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
CFAMM00152479 CHEMBL1098376 Bioactive SureCN1555089
CFAMM00152377 CHEMBL2172492 Bioactive (3S,3'R,4'S,5'S,6'R)-6'-(hydroxymethyl)-5-[(4-propylphenyl)methyl]spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
CFAMM00152419 CHEMBL1091811 Bioactive (6S,7R,8R,9S)-6-[3-[(4-ethylphenyl)methyl]-4-methylphenyl]-2,5-dioxaspiro[3.5]nonane-7,8,9-triol
CFAMM00152524 CHEMBL585482 Bioactive (3S,3'R,4'S,5'S,6'R)-6-chloro-7-[(4-ethylphenyl)methyl]-6'-(methoxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
CFAMM00152376 CHEMBL2172493 Bioactive (3S,3'R,4'S,5'S,6'R)-6'-(hydroxymethyl)-5-[(4-propan-2-ylphenyl)methyl]spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
CFAMM00152415 DCL000614 Clinical Trial Drug R7201
CFAMM00152441 DNCL003542 Clinical Trial Drug Tofogliflozin

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543