CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD350
Family Name Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family
No. of Seeds 16 No. of Other Members 124
Family Centroid CFAMM00152708 Functional Category Clinical Trial Drug
Superfamily Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Superfamily
Class Class 1049

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Epidermal growth factor receptor and Receptor tyrosine-protein... 9 65
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
SB1518 family 7 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Varlitinib family 2 8
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
B2 bradykinin receptor Ligand FR-173657 Family 44 180
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
Dual specificity mitogen-activated protein kinase kinase 1 inh... 10 54
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YXQ ... 2 1
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 and Fibroblast g... 3 11
Vascular endothelial growth factor receptor 2 and Fibroblast g... 10 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Renin inhibitor AGN-PC-09M4GD family 3 4
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Epidermal growth factor receptor and Mitogen-activated protein... 5 19
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 2
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Vascular endothelial growth factor receptor 2 ligand 1-[4-[6-a... 11 13
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Fatty-acid amide hydrolase 1 inhibitor (1R)-2-[[6-(3-chloro-4-... 1 4
Hepatocyte growth factor receptor ligand [3,5-dichloro-4-[4-(3... 1 1
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Receptor tyrosine-protein kinase erbB-2 ligand 2-[2-[4-[3-chlo... 4 5
Tyrosine-protein kinase JAK2 inhibitor N-[3-chloro-4-(4-methyl... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 2 0
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Fatty-acid amide hydrolase 1 inhibitor N-(2,1,3-benzothiadiazo... 1 1
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand pheny... 1 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 14 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 0
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Glucagon receptor ligand SureCN2647807 family 3 7
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 4 24
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 1
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJ2 family 1 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 7 4
Beta-secretase 1 and Amyloid beta A4 protein inhibitor SureCN3... 1 5
Neuropeptide S receptor ligand 5-(4-chlorophenyl)-6-methoxy-5-... 4 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0760YR family 1 0
Bifunctional epoxide hydrolase 2 and Arachidonate 5-lipoxygena... 3 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00152670 CHEMBL1923010 Bioactive 2-[2-[4-[3-chloro-4-[3-(trifluoromethyl)phenoxy]anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy]ethanol
CFAMM00152748 CHEMBL1923022 Bioactive N-[2-[4-[3-chloro-4-[3-(trifluoromethyl)phenoxy]anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethyl]-3-hydroxypropanamide;methanesulfonic acid
CFAMM00152663 CHEMBL2148048 Bioactive N-[2-[4-[3-chloro-4-[3-(trifluoromethyl)phenoxy]anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethyl]-2-methylsulfonylpropanamide
CFAMM00152747 CHEMBL1923020 Bioactive N-[2-[4-[3-chloro-4-[3-(trifluoromethyl)phenoxy]anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethyl]-2-hydroxy-N-methylacetamide
CFAMM00152740 CHEMBL1922999 Bioactive N-[3-chloro-4-(3-methylphenoxy)phenyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine
CFAMM00152660 CHEMBL2148044 Bioactive N-[2-[4-[3-chloro-4-[3-(trifluoromethyl)phenoxy]anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethyl]-2-methylsulfonylacetamide
CFAMM00152673 CHEMBL1923014 Bioactive 2-[2-[4-[3-chloro-4-[3-(trifluoromethyl)phenoxy]anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethylsulfanyl]ethanol
CFAMM00152617 CHEMBL1683967 Bioactive (Z)-3-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-6-methylpyrimidin-5-yl]-2-fluoro-N-(2-pyrrolidin-1-ylethyl)prop-2-enamide
CFAMM00152752 CHEMBL1922902 Bioactive 3-[2-chloro-4-(5H-pyrrolo[3,2-d]pyrimidin-4-ylamino)phenoxy]benzonitrile
CFAMM00152666 CHEMBL2048788 Bioactive N-tert-butyl-3-[2-chloro-4-[[5-(2-hydroxyethyl)pyrrolo[3,2-d]pyrimidin-4-yl]amino]phenoxy]benzamide
CFAMM00152692 CHEMBL2048794 Bioactive 7-[2-chloro-4-[[5-(2-hydroxyethyl)pyrrolo[3,2-d]pyrimidin-4-yl]amino]phenoxy]-2,3-dihydroisoindol-1-one
CFAMM00152659 CHEMBL2148045 Bioactive N-[2-[4-[3-chloro-4-[3-(trifluoromethyl)phenoxy]anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethyl]-2-ethylsulfonylacetamide
CFAMM00152733 CHEMBL2322329 Bioactive (E)-N-[2-[4-[3-chloro-4-[3-(trifluoromethyl)phenoxy]anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethyl]-4-(dimethylamino)but-2-enamide
CFAMM00152672 CHEMBL1923013 Bioactive 2-[2-[4-[3-chloro-4-[3-(trifluoromethyl)phenoxy]anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethylamino]ethanol
CFAMM00152678 CHEMBL1923019 Bioactive N-[2-[4-[3-chloro-4-[3-(trifluoromethyl)phenoxy]anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethyl]-2-hydroxyacetamide
CFAMM00152708 DCL000649 Clinical Trial Drug TAK-285

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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