CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD356
Family Name Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619 Family
No. of Seeds 3 No. of Other Members 61
Family Centroid CFAMM00152848 Functional Category Clinical Trial Drug with Natural Product
Superfamily Cathepsin K and Neuronal acetylcholine receptor subunit alpha-4 Binder Superfamily
Class Class 918

Cousin Family NamesSeedsMembers
Cathepsin K Inhibitor Relacatib Family 26 32
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
5-hydroxytryptamine receptor 3A and Neuronal acetylcholine rec... 1 3
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Pol polyprotein inhibitor AC1LARNY family 28 17
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Gonadotropin-releasing hormone receptor ligand AGN-PC-034WF4 f... 8 23
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 6 9
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 8 12
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Cytochrome P450 2C19 and Inositol monophosphatase 1 inhibitor ... 1 0
Histamine H3 receptor ligand SureCN2784306 family 5 3
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
MAP kinase-activated protein kinase 2 inhibitor 5-(4-cyanophen... 3 8
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 3 1
Collagenase 3 inhibitor AGN-PC-03HW1J family 4 0
MAP kinase-activated protein kinase 2 inhibitor 4-[5-[[2-(2-me... 3 4
MAP kinase-activated protein kinase 2 inhibitor 4-[4-oxo-8-pip... 4 0
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 4 4
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 1 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Cathepsin K and Cathepsin L1 inhibitor AC1NR9VX family 2 2
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-073HN6 f... 1 1
Substance-P receptor ligand SureCN2139814 family 7 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 1
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Collagenase 3 inhibitor SureCN1316041 family 4 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M5I2 fa... 1 3
MAP kinase-activated protein kinase 2 inhibitor 3-[5-(4-chloro... 6 5
Diacylglycerol O-acyltransferase 1 inhibitor 2-[[4-[5-[(3-meth... 2 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00152848 DCL000658 Clinical Trial Drug TC-5619
CFAMM00152811 DNC006727 Investigative Drug PHA-543613

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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