CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD357
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor UK-369003 Family
No. of Seeds 35 No. of Other Members 10
Family Centroid CFAMM00152916 Functional Category Clinical Trial Drug
Superfamily cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Sildenafil Superfamily
Class Class 363

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Sildena... 17 40


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00152912 CHEMBL1928274 Bioactive 2-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-propoxypyridin-3-yl]-7,8,9,10-tetrahydro-1H-pyrido[3,4]pyrazolo[1,3-b]pyrimidin-4-one
CFAMM00152925 CHEMBL1928255 Bioactive 3-ethyl-5-[2-(2-methoxyethoxy)-5-(4-methylpiperazin-1-yl)sulfonylpyridin-3-yl]-2-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152895 CHEMBL1928265 Bioactive 5-[2-butoxy-5-(4-ethylpiperazin-1-yl)sulfonylpyridin-3-yl]-3-ethyl-2-(1-methylsulfonylpiperidin-4-yl)-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152918 CHEMBL1928258 Bioactive 3-ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-propoxypyridin-3-yl]-2-(2-methoxyethyl)-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152931 CHEMBL514435 Bioactive SureCN3581056
CFAMM00152924 CHEMBL1928256 Bioactive 3-ethyl-5-[2-(2-methoxyethoxy)-5-(4-methylpiperazin-1-yl)sulfonylpyridin-3-yl]-2-(2-methylpropyl)-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152917 CHEMBL1928259 Bioactive 3-ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methylpropoxy)pyridin-3-yl]-2-(2-methoxyethyl)-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152894 CHEMBL1928264 Bioactive 2-[3-(dimethylamino)propyl]-3-ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methylpropoxy)pyridin-3-yl]-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152930 CHEMBL1928276 Bioactive 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylpyridin-3-yl]-10-methyl-7,8,9,10-tetrahydro-1H-pyrido[3,4]pyrazolo[1,3-b]pyrimidin-4-one
CFAMM00152909 CHEMBL1928275 Bioactive 2-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methoxyethoxy)pyridin-3-yl]-7,8,9,10-tetrahydro-1H-pyrido[3,4]pyrazolo[1,3-b]pyrimidin-4-one
CFAMM00152923 CHEMBL1928271 Bioactive 5-[2-(cyclopropylmethoxy)-5-(4-ethylpiperazin-1-yl)sulfonylpyridin-3-yl]-3-ethyl-2-(2-morpholin-4-ylethyl)-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152893 CHEMBL1928266 Bioactive 5-[2-butoxy-5-(4-ethylpiperazin-1-yl)sulfonylpyridin-3-yl]-3-ethyl-2-(1-methylpiperidin-4-yl)-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152929 CHEMBL1928272 Bioactive 3-ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methoxyethoxy)pyridin-3-yl]-2-(2-morpholin-4-ylethyl)-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152922 CHEMBL1928250 Bioactive 3-ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methoxyethoxy)pyridin-3-yl]-2-propan-2-yl-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152899 CHEMBL1928261 Bioactive 3-ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methoxyethoxy)pyridin-3-yl]-2-(2-methoxyethyl)-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152908 CHEMBL1928263 Bioactive 5-[2-butoxy-5-(4-ethylpiperazin-1-yl)sulfonylpyridin-3-yl]-2-[2-(dimethylamino)ethyl]-3-ethyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152915 CHEMBL1928277 Bioactive 2-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methoxyethoxy)pyridin-3-yl]-10-methyl-7,8,9,10-tetrahydro-1H-pyrido[3,4]pyrazolo[1,3-b]pyrimidin-4-one
CFAMM00152892 CHEMBL1928269 Bioactive 5-[2-butoxy-5-(4-ethylpiperazin-1-yl)sulfonylpyridin-3-yl]-3-ethyl-2-(1-methylazetidin-3-yl)-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152928 CHEMBL460294 Bioactive 3-ethyl-5-[2-[(2R)-1-methoxypropan-2-yl]oxy-5-(4-propylpiperazin-1-yl)sulfonylpyridin-3-yl]-2-methyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152898 CHEMBL1928260 Bioactive 3-ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(pyridin-2-ylmethoxy)pyridin-3-yl]-2-(2-methoxyethyl)-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152921 CHEMBL1928251 Bioactive 2-cyclobutyl-3-ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methoxyethoxy)pyridin-3-yl]-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152891 CHEMBL1928268 Bioactive N-[3-carbamoyl-5-ethyl-1-(1-methylazetidin-3-yl)pyrazol-4-yl]-2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylpyridine-3-carboxamide
CFAMM00152904 CHEMBL455187 Bioactive 3-ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-[(1R)-1-pyridin-2-ylethoxy]pyridin-3-yl]-2-methyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152927 CHEMBL455452 Bioactive 5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methoxyethoxy)pyridin-3-yl]-2-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152897 CHEMBL1928249 Bioactive 3-ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methoxyethoxy)pyridin-3-yl]-2-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152920 CHEMBL1928252 Bioactive 3-ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methoxyethoxy)pyridin-3-yl]-2-(2-methylpropyl)-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152890 CHEMBL444157 Bioactive 3-ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-[(2R)-1-methoxypropan-2-yl]oxypyridin-3-yl]-2-(pyridin-2-ylmethyl)-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152903 CHEMBL1928270 Bioactive 5-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylpyridin-3-yl]-3-ethyl-2-(2-morpholin-4-ylethyl)-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152926 CHEMBL1928254 Bioactive 3-ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methoxyethoxy)pyridin-3-yl]-2-(oxan-4-yl)-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152896 CHEMBL1928262 Bioactive GISADENAFIL
CFAMM00152919 CHEMBL1928253 Bioactive 2-(cyclopropylmethyl)-3-ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methoxyethoxy)pyridin-3-yl]-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00152932 CHEMBL209157 Bioactive SureCN314617
CFAMM00152916 DCL000661 Clinical Trial Drug UK-369003
CFAMM00152906 DNC009615 Investigative Drug UK-371800
CFAMM00152905 DNC009616 Investigative Drug UK-343664

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21768 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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