CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD36
Family Name Mitogen-activated protein kinase 12 Inhibitor ARRY-797 Family
No. of Seeds 13 No. of Other Members 41
Family Centroid CFAMM00130103 Functional Category Clinical Trial Drug
Superfamily Mitogen-activated protein kinase 12 Inhibitor ARRY-797 Superfamily
Class Class 842

Cousin Family NamesSeedsMembers
Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family 20 43
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 50 36
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 5 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
5-hydroxytryptamine receptor 3A ligand 1-[4-[[7-(diethylamino)... 2 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 6 2
Platelet-derived growth factor receptor beta and Macrophage co... 8 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
5-hydroxytryptamine receptor 3A ligand 5-hydroxy-1-methyl-N-[(... 4 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
G-protein coupled bile acid receptor 1 ligand (4-cyclopropyl-2... 2 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 7-met... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor 1-(4-methoxyphenyl)-3... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07C3OU fa... 6 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 25 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-07R5ZB family 4 3
Glucagon receptor ligand AGN-PC-0DAGZC family 3 12
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Dual specificity mitogen-activated protein kinase kinase 1 inh... 2 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00130106 CHEMBL1085615 Bioactive AGN-PC-07YIIM
CFAMM00130084 CHEMBL1082183 Bioactive AGN-PC-07Z9R1
CFAMM00130129 CHEMBL1086316 Bioactive AGN-PC-00AFJ8
CFAMM00130077 CHEMBL1084895 Bioactive AGN-PC-00ERSS
CFAMM00130112 CHEMBL1086555 Bioactive AGN-PC-07YIQD
CFAMM00130090 CHEMBL1083751 Bioactive AGN-PC-00BGM1
CFAMM00130082 CHEMBL1088166 Bioactive AGN-PC-07ZA6M
CFAMM00130075 CHEMBL1081037 Bioactive AGN-PC-07Z9RO
CFAMM00130089 CHEMBL1083750 Bioactive AGN-PC-07YIIJ
CFAMM00130119 CHEMBL1082795 Bioactive AGN-PC-07YIYF
CFAMM00130095 CHEMBL1085854 Bioactive AGN-PC-00ED3L
CFAMM00130110 CHEMBL1082159 Bioactive AGN-PC-07Z9PZ
CFAMM00130103 DCL000054 Clinical Trial Drug ARRY-797

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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