CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD365
Family Name Sodium- and chloride-dependent glycine transporter 1 Inhibitor ALX-5407 Family
No. of Seeds 6 No. of Other Members 33
Family Centroid CFAMM00153267 Functional Category Clinical Trial Drug with Natural Product
Superfamily Sodium- and chloride-dependent glycine transporter 1 Inhibitor ALX-5407 Superfamily
Class Class 51

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Thymopentin family 20 133
Gadoxetate family 1 3
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Extracellular calcium-sensing receptor Ligand Ronacaleret Family 2 9
Beta-3 adrenergic receptor Ligand Amibegron Family 8 46
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 2A Ligand Pimavanserin Family 4 23
D(3) dopamine receptor Ligand U-99194A Family 7 33
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Thyroid hormone receptor beta Ligand (3,5-dibromo-4-pentyloxy-... 5 21
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 3 27
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Leukotriene A-4 hydrolase inhibitor 3-[3-(4-benzylphenoxy)prop... 2 0
Extracellular calcium-sensing receptor and Sodium-dependent no... 2 2
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 4 10
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 7 0
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 117
Neprilysin inhibitor SureCN389939 family 5 6
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Sigma non-opioid intracellular receptor 1 ligand methyl (1R,2S... 4 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 12 0
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
5-hydroxytryptamine receptor 1A ligand oxalic acid;(1R,5S)-5-[... 2 0
Pol polyprotein inhibitor MDL 74538 family 11 1
Muscarinic acetylcholine receptor M5 and Muscarinic acetylchol... 1 3
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 3 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 1 0
Muscleblind-like protein 1 and Ferritin light chain inhibitor ... 1 1
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 1 0
Sodium- and chloride-dependent GABA transporter 1 inhibitor (3... 2 1
Free fatty acid receptor 1 ligand 3-[4-[2-[2-(cyanomethoxy)phe... 1 2
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 5 3
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 2 1
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor AGN-PC-07... 2 6
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Sigma non-opioid intracellular receptor 1 ligand tert-butyl 2-... 1 1
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
Cytochrome P450 2D6 and Sodium channel protein type 1 subunit ... 1 1
Putative NP ZINC04061066 Family 18 0
NP N-(4-chlorobenzyl)-n-(3-(4-isopropoxyphenyl)-3-phenylpropyl... 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00153266 CHEMBL26512 Bioactive NFPS
CFAMM00153281 CHEMBL117549 Bioactive 2-[4-(4-benzylphenoxy)butylamino]acetic acid
CFAMM00153264 CHEMBL543405 Bioactive SC 57461A
CFAMM00153268 CHEMBL112671 Bioactive N-[3-(4-Benzylphenoxy)propyl]-N-Methyl-Beta-Alanine
CFAMM00153267 DCL000690 Clinical Trial Drug ALX-5407
CFAMM00153275 DPR000084 Investigative Drug Org-24461

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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