CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Beta-3 adrenergic receptor Ligand Amibegron Family
No. of Seeds 8 No. of Other Members 46
Family Centroid CFAMM00153380 Functional Category Clinical Trial Drug
Superfamily Adrenergic receptor ligand Propranolol Levobunolol Metipranolol Superfamily
Class Class 80

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Serine/threonine-protein kinase PLK1 Inhibitor On Fa... 16 138
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Extracellular calcium-sensing receptor and Potassium voltage-g... 3 11
Amine oxidase [flavin-containing] B Inhibitor (r)-n2-{4-[(3-ch... 3 0
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 6 21
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[(2... 10 12
Sodium-dependent noradrenaline transporter and Sodium-dependen... 14 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 15 13
Plasmepsin-2 and Cathepsin D inhibitor N-[2-(1,3-benzodioxol-5... 4 0
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 5
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 0
Beta-3 adrenergic receptor ligand 5-[[(7S)-7-[[(2R)-2-(3-chlor... 6 3
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 7 4
Growth hormone secretagogue receptor type 1 ligand N-benzyl-2-... 5 19
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 0
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 2 0
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 8


External ID

Functional Category

Molecule Name

CFAMM00153343 CHEMBL284782 Bioactive CHEBI:132852
CFAMM00153365 CHEMBL545437 Bioactive Amibegron HCl
CFAMM00153356 CHEMBL38486 Bioactive SureCN5144151
CFAMM00153344 DCL000890 Clinical Trial Drug N-5984
CFAMM00153380 DCL000695 Clinical Trial Drug Amibegron
CFAMM00153345 DNC003984 Investigative Drug BRL-37344
CFAMM00153388 DNC000347 Investigative Drug BRL 37344
CFAMM00153389 DNC000346 Investigative Drug BRL 35135

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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