CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD370
Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Arofylline Family
No. of Seeds 3 No. of Other Members 196
Family Centroid CFAMM00153537 Functional Category Clinical Trial Drug with Natural Product
Superfamily cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Arofylline Superfamily
Class Class 1060

Cousin Family NamesSeedsMembers
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Dipeptidyl peptidase 4 Inhibitor SSR-162369 Family 8 27
GP-531 family 1 33
Plinabulin family 1 0
Toll-like receptor 7 Ligand GS-9620 Family 2 4
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Adenosine receptor A1 and Adenosine receptor A2b Ligand PSB-11... 34 26
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Histamine H3 receptor Ligand SCH79687 Family 11 29
Herpes simplex virus type 1 thymidine kinase Inhibitor 9-(4-hy... 2 13
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 5 7
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
Adenosine receptor A2a Ligand (e,e)-8-(4-phenylbutadien-1-yl)c... 11 43
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 6 14
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SCH-577... 9 29
Herpes simplex virus type 1 thymidine kinase Inhibitor N2-(3-t... 1 2
Prothrombin inhibitor SureCN5856722 family 3 16
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN1... 6 16
Adenosine receptor A1 ligand 4-[5-(8-cyclopentyl-2,6-dioxo-1-p... 3 4
Adenosine receptor A1 ligand SureCN10614388 family 5 1
Adenosine receptor A1 ligand 8-(2-amino-4-nitrophenyl)-1,3-dim... 1 0
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 2 1
Dipeptidyl peptidase 4 inhibitor Xanthine Analogue 4 family 1 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-046QKE family 3 5
Histamine H4 receptor ligand SureCN602132 family 1 8
Vascular endothelial growth factor receptor 2 ligand AC1LLCDM ... 1 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Prelamin-A/C inhibitor CHEMBL1503535 family 1 0
Cellular tumor antigen p53 and Thyrotropin receptor ligand CHE... 1 5
Adenosine receptor A3 and Adenosine receptor A1 ligand (8R)-8-... 4 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Metabotropic glutamate receptor 5 ligand SureCN3866791 family 2 10
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 4 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Adenosine receptor A2b ligand (8Z)-8-(6-oxopyridin-3-ylidene)-... 1 0
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Adenosine receptor A3 ligand 3-(cyclopropylmethyl)-8-methoxy-1... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 1 0
Prothrombin inhibitor N-(2-aminoethyl)-2-[5-[[3-(benzylsulfony... 17 5
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 2
Adenosine receptor A1 ligand 3-(4-Aminophenethyl)-8-(3-noradam... 1 0
Tripeptidyl-peptidase 2 inhibitor (2S)-2-amino-1-[(2S)-5-chlor... 1 0
Corticotropin-releasing factor receptor 1 ligand SureCN6323029... 2 13
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00153537 DCL000700 Clinical Trial Drug Arofylline
CFAMM00153436 DNC004216 Investigative Drug 1-Benzyl-3-methyl-3,7-dihydro-purine-2,6-dione
CFAMM00153435 DNC004215 Investigative Drug 3-Methyl-1-phenethyl-3,7-dihydro-purine-2,6-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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