CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD371
Family Name 5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Ligand Asenapine Family
No. of Seeds 4 No. of Other Members 35
Family Centroid CFAMM00153727 Functional Category Clinical Trial Drug
Superfamily 5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Ligand Asenapine Superfamily
Class Class 1061

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Histamine H1 receptor Ligand Clemastine Family 5 76
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Substance-P receptor Ligand Ezlopitant Family 10 207
D(3) dopamine receptor Ligand U-99194A Family 7 33
Dapoxetine family 3 40
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Dipeptidyl peptidase 4 Inhibitor (2-chloro-6-phenoxyphenyl)met... 17 24
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Inhibitor 2... 1 9
D(4) dopamine receptor ligand AGN-PC-0073PO family 7 10
Sigma non-opioid intracellular receptor 1 and 3-beta-hydroxyst... 15 11
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 7 0
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Sodium-dependent serotonin transporter and Sodium-dependent no... 6 21
Transporter and 5-hydroxytryptamine receptor 2C ligand CHEMBL1... 5 5
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-(4-... 2 6
Histamine H3 receptor ligand SureCN6071181 family 2 1
Histamine H3 receptor ligand AGN-PC-0765YW family 1 4
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 14 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Sodium-dependent serotonin transporter inhibitor 4-(4-chloro-2... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00153705 CHEMBL11803 Bioactive SureCN8197911
CFAMM00153708 CHEMBL1201756 Bioactive Asenapine
CFAMM00153727 DCL000703 Clinical Trial Drug Asenapine
CFAMM00153717 DNC003797 Investigative Drug SK&F-104078

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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