CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD372
Family Name Kappa-type opioid receptor Ligand Asimadoline Family
No. of Seeds 14 No. of Other Members 54
Family Centroid CFAMM00153788 Functional Category Clinical Trial Drug
Superfamily Kappa-type opioid receptor Ligand Asimadoline Superfamily
Class Class 1062

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Motilin receptor Ligand GSK962040 Family 30 457
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 2 18
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Pan-DAC Inhibitor AR-42 Family 21 153
Bavisant family 9 65
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Vasopressin-neurophysin 2-copeptin Inhibitor Niravoline Family 7 45
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
5-hydroxytryptamine receptor 4 Ligand TD-5108 Family 21 24
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Beta-secretase 1 Inhibitor KMI-538 Family 4 20
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Beta-secretase 1 Inhibitor GSK-188909 Family 16 11
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 5 11
B1 bradykinin receptor ligand SureCN4136698 family 6 33
Baculoviral IAP repeat-containing protein 2 and Baculoviral IA... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 9
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
Vesicular acetylcholine transporter inhibitor (3R,4R)-1-[(3-io... 17 20
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 5 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Pol polyprotein inhibitor AC1LAMTL family 11 15
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Kappa-type opioid receptor ligand 3,4-dichloro-N-[2-[[(1S)-2-[... 1 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 2 1
Kappa-type opioid receptor ligand N-methyl-N-[(1S)-2-pyrrolidi... 3 17
Melanin-concentrating hormone receptor 1 ligand 1-[4-(3-cyanop... 4 9
Kappa-type opioid receptor and Delta-type opioid receptor liga... 9 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 11 9
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 13 3
Cathepsin D and Cathepsin E inhibitor methyl (2S)-1-[(2R)-2-[[... 1 0
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
Kappa-type opioid receptor ligand 1-[4-acetyl-2-[[(3S)-3-hydro... 2 1
Histamine receptor H3 ligand N-[2-methyl-4-[(3S)-3-[(2S)-2-met... 10 7
Histamine receptor H3 ligand N-[4-[3-(2-methylpyrrolidin-1-yl)... 2 0
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Prothrombin and Cationic trypsin inhibitor (2S)-N-[[4-[(Z)-C-a... 6 3
Kappa-type opioid receptor ligand 1-[4-acetyl-2-[[(3S)-3-hydro... 1 0
Kappa-type opioid receptor ligand 1-[4-acetyl-2-[[(3S)-3-hydro... 1 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 1
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Pol polyprotein inhibitor 4-benzyl-N-[(2S)-1-[[(2S,3R,4S,5S)-5... 3 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 2 1
Kappa-type opioid receptor ligand 3-[3-(hydroxymethyl)phenyl]-... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 9
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1
Histamine H3 receptor ligand [(3aR,6aR)-4-[4-[2-[(2R)-2-methyl... 6 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Vesicular acetylcholine transporter and Sigma non-opioid intra... 1 1
Muscarinic acetylcholine receptor M4 and Potassium voltage-gat... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00153764 CHEMBL189643 Bioactive 2-[4-[(benzylsulfonylamino)methyl]phenyl]-N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methylacetamide
CFAMM00153776 CHEMBL540345 Bioactive N-[(1S)-1-(3-acetamidophenyl)-2-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl]-N-methyl-2,2-diphenylacetamide;hydrochloride
CFAMM00153782 CHEMBL540342 Bioactive ASIMADOLINE HYDROCHLORIDE
CFAMM00153796 CHEMBL543236 Bioactive N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methyl-9,10-dihydroanthracene-9-carboxamide;hydrochloride
CFAMM00153744 CHEMBL538063 Bioactive N-[(1S)-1-(3-aminophenyl)-2-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl]-N-methyl-2,2-diphenylacetamide;hydrochloride
CFAMM00153801 CHEMBL553085 Bioactive N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methyl-9H-thioxanthene-9-carboxamide;hydrochloride
CFAMM00153754 CHEMBL542036 Bioactive 2,2-bis(4-fluorophenyl)-N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methylacetamide;hydrochloride
CFAMM00153794 CHEMBL278708 Bioactive AGN-PC-0746ZM
CFAMM00153773 CHEMBL543947 Bioactive N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methyl-9H-fluorene-9-carboxamide;hydrochloride
CFAMM00153786 CHEMBL425897 Bioactive SureCN5844421
CFAMM00153749 CHEMBL543476 Bioactive 2,2-bis(4-chlorophenyl)-N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methylacetamide;hydrochloride
CFAMM00153772 CHEMBL555800 Bioactive N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N,3-dimethyl-2-phenylbutanamide;hydrochloride
CFAMM00153765 CHEMBL545346 Bioactive 2-cyclohexyl-N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methyl-2-phenylacetamide;hydrochloride
CFAMM00153788 DCL000704 Clinical Trial Drug Asimadoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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