CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD383
Family Name Adenosine receptor A2a Ligand BIIB014 Family
No. of Seeds 26 No. of Other Members 92
Family Centroid CFAMM00153967 Functional Category Clinical Trial Drug with Natural Product
Superfamily Adenosine receptor A2a and Serine/threonine-protein kinase mTOR Binder Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Kinetin family 2 39
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
MK-3328 family 2 32
Ibrutinib family 2 27
Adenosine receptor A1 and Adenosine receptor A2a Ligand CGS-15... 24 47
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Adenosine receptor A1 and Adenosine receptor A2a Ligand ZM-241... 2 5
Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family 39 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Sodium-dependent serotonin transporter Inhibitor 4-furan-2-yl-... 2 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... 3 47
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Potassium voltage-gated channel subfamily H member 2 and Neuro... 3 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 3
Histamine H4 receptor and Histamine H3 receptor ligand SureCN6... 17 51
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 1
Adenosine receptor A2a ligand SureCN6867940 family 13 13
5-hydroxytryptamine receptor 6 ligand F1609-0206 family 2 6
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 9 inhibitor Su... 3 1
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 6 9
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Survival motor neuron protein and Neuropeptide S receptor liga... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 7 4
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 5 8
Adenosine receptor A2b and Adenosine receptor A2a ligand AGN-P... 2 0
Adenosine receptor A2a ligand 5-N-[[(2R)-1-[(2-chloro-3,6-difl... 7 9
Adenosine kinase inhibitor 7-[(4aS,7aS)-6-benzyl-3,4,4a,5,7,7a... 2 1
Adenosine receptor A2a ligand 5-[[[(2R)-1-[(2-chloropyridin-4-... 5 0
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
5-hydroxytryptamine receptor 1F ligand AGN-PC-075AYH family 2 1
Adenosine receptor A2a ligand 7-(3,4-dimethoxyphenyl)-2-(furan... 6 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
Vascular endothelial growth factor receptor 1 and Vascular end... 11 38
Histamine H4 receptor ligand 8-fluoro-4-[(3R)-3-(methylamino)p... 6 1
Histamine H4 receptor ligand 8-chloro-4-[(3R)-3-(methylamino)p... 1 1
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1938684 ... 5 6
Prothrombin inhibitor SureCN6925359 family 6 18
Adenosine receptor A2a ligand 9-[(6-chloro-1,3-benzodioxol-5-y... 1 0
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 3
Histamine H3 receptor ligand N-[[2-[2-[(2R)-2-methylpyrrolidin... 4 1
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 1 0
Glycogen synthase kinase-3 beta inhibitor 2-(furan-3-yl)-N-[2-... 3 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
Scavenger receptor class B member 1 ligand 2-[9-[3-(4,6-dimeth... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 6
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 5-[(7S... 6 1
Adenosine receptor A2a ligand 5-[(7S,9aS)-7-[(2-fluorophenoxy)... 5 4
Cannabinoid receptor 2 ligand N-cyclohexyl-2-(furan-2-yl)-7-ox... 3 1
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 4
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Tyrosine-protein kinase ITK/TSK and Aurora kinase B inhibitor ... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 3
Adenosine receptor A2a ligand 3-[(2-bromophenyl)methyl]-8-(fur... 2 0
Adenosine receptor A2a ligand 8-(furan-2-yl)-3-[2-[4-(1,3-thia... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 25 5
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 1 2
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-075YVI ... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 1 1
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 3 0
Platelet-activating factor receptor ligand AGN-PC-00GDIY family 1 1
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 1 0
Adenosine receptor A2a ligand SureCN8368237 family 1 0
Adenosine receptor A2a ligand AGN-PC-02Z2S3 family 3 0
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-03J2ZU f... 1 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 2
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Adenosine receptor A2a and Adenosine receptor A1 ligand triazi... 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 0
Serine/threonine-protein kinase Chk1 and Cyclin-A2 inhibitor S... 1 0
Fatty-acid amide hydrolase 1 inhibitor (Z)-1-(4-pyrimidin-4-yl... 1 0
Cysteine protease and Cathepsin L1 inhibitor AGN-PC-076NDO family 1 0
G1/S-specific cyclin-E2 and G1/S-specific cyclin-E1 inhibitor ... 1 0
Metabotropic glutamate receptor 5 ligand AGN-PC-09QKEE family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00153982 CHEMBL195364 Bioactive AGN-PC-00BPYD
CFAMM00154007 CHEMBL195410 Bioactive 9H-Purin-2-amine, 6-(2-furanyl)-9-[(4-methoxyphenyl)methyl]-
CFAMM00153973 CHEMBL260209 Bioactive 9-[(2-fluorophenyl)methyl]-6-(furan-2-yl)purin-2-amine
CFAMM00154018 CHEMBL261534 Bioactive 6-(furan-2-yl)-9-[(3-methylphenyl)methyl]purin-2-amine
CFAMM00154036 CHEMBL193613 Bioactive AGN-PC-075VXV
CFAMM00153991 CHEMBL195294 Bioactive SureCN3268974
CFAMM00154083 CHEMBL424827 Bioactive SureCN3269689
CFAMM00154025 CHEMBL193761 Bioactive SureCN3267840
CFAMM00153975 CHEMBL371436 Bioactive SureCN3268210
CFAMM00153967 DCL000725 Clinical Trial Drug BIIB014
CFAMM00154055 DNC008478 Investigative Drug 9-(4-nitrobenzyl)-6-(furan-2-yl)-9H-purin-2-amine
CFAMM00154054 DNC008479 Investigative Drug 9-(3-nitrobenzyl)-6-(furan-2-yl)-9H-purin-2-amine
CFAMM00153986 DNC005426 Investigative Drug 6-Furan-2-yl-9-phenethyl-9H-purin-2-ylamine
CFAMM00153985 DNC005424 Investigative Drug 6-Furan-2-yl-9-phenyl-9H-purin-2-ylamine
CFAMM00153984 DNC005425 Investigative Drug 9-benzyl-6-(furan-2-yl)-9H-purin-2-amine
CFAMM00154056 DNC008477 Investigative Drug 9-(3-aminobenzyl)-6-(furan-2-yl)-9H-purin-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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